“…PRP can effectively prevent and treat neovascularization, which could benefit from quantifying the area of the RNP to select the timing of PRP use. The severity of macular ischemia increases as the VD in the macular area reduces and the RNP area expands, accurately quantifying the VD and the RNP area can be used to grade macular ischemia in RVO patients, and accurately quantifying the VD and the RNP areas can be used to grade macular ischemia in patients with RVO and assess disease severity and prognosis ( Ouederni et al, 2019 ; Tang et al, 2021 ; Yeung et al, 2021 ). Huang et al, 2022 classified patients with branch vein occlusion (BRVO) into reactive and refractory groups based on their responses to anti-VEGF treatment, which was determined by semi-automatic quantitative fluorescein angiography to measure the amount of fluorescein leakage around and near the fovea of the macular area in patients with BRVO.…”