Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice

Mori, Daisuke; Katayama, Tasuku; Miyake, Hidekazu; Fujiwara, Shuu; Kubo, Kin‐ya

doi:10.1016/j.neulet.2012.12.004

Cited by 24 publications

(28 citation statements)

References 33 publications

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“…Neuroendocrine activation of the HPA axis is counteracted by GR-mediated negative feedback, which terminates the stress response. Masticatory dysfunction inhibited the negative-feedback response by downregulation of GR protein and mRNA expression 16. In aged mice, the molarless or bite-raised condition suppressed cell proliferation in the hippocampal DG 15, 21.…”

Section: Chewing Stimulation Helps To Maintain the Hippocampal Functionmentioning

confidence: 96%

“…Masticatory stimulation may prevent degradation of senile brain function and stress-related disorders without medication. The decrease of masticatory function, by either extraction of or reduction in molars and associated long-term soft-diet feeding, can inhibit learning and memory 12, 13, 16, 18, 19, 22, 33, 34. Learning ability was shown to decrease in adult rats from 2 to 30 months after the extraction of molars 13, 28, 29.…”

Section: The Neural Circuits Between Masticatory Organs and Hippocampusmentioning

confidence: 99%

“…In animal experiments, molar extraction 13, 14, occlusal disharmony or bite-raised condition 16, 17, soft-diet feeding 28, 29 and chewing wooden sticks 21, 22 are common used for examining masticatory functions. In human studies, the independent variables include self-reported dental status and chewing difficulty 9, 30.…”

Section: Functional Analysis Of Masticatory Apparatusmentioning

confidence: 99%

See 2 more Smart Citations

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chen¹,

Iinuma²,

Onozuka³

et al. 2015

Int. J. Med. Sci.

Self Cite

105

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Mastication (chewing) is important not only for food intake, but also for preserving and promoting the general health. Recent studies have showed that mastication helps to maintain cognitive functions in the hippocampus, a central nervous system region vital for spatial memory and learning. The purpose of this paper is to review the recent progress of the association between mastication and the hippocampus-dependent cognitive function. There are multiple neural circuits connecting the masticatory organs and the hippocampus. Both animal and human studies indicated that cognitive functioning is influenced by mastication. Masticatory dysfunction is associated with the hippocampal morphological impairments and the hippocampus-dependent spatial memory deficits, especially in elderly. Mastication is an effective behavior for maintaining the hippocampus-dependent cognitive performance, which deteriorates with aging. Therefore, chewing may represent a useful approach in preserving and promoting the hippocampus-dependent cognitive function in older people. We also discussed several possible mechanisms involved in the interaction between mastication and the hippocampal neurogenesis and the future directions for this unique fascinating research.

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Section: Chewing Stimulation Helps To Maintain the Hippocampal Functionmentioning

confidence: 96%

Section: The Neural Circuits Between Masticatory Organs and Hippocampusmentioning

confidence: 99%

Section: Functional Analysis Of Masticatory Apparatusmentioning

confidence: 99%

See 1 more Smart Citation

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chen¹,

Iinuma²,

Onozuka³

et al. 2015

Int. J. Med. Sci.

Self Cite

105

View full text Add to dashboard Cite

show abstract

“…Thus, a greater number of participants are needed to assess the importance of all variables. Activation of cerebral activity was found to increase significantly in the dorsal PFC during chewing while wearing a dental prosthesis, compared with controls without dentures, although experimental studies in animal models suggested that other cerebral zones are activated during mastication, not only the PFC. Furthermore, according to the study by Kamiya et al ., 12 prefrontal activation is not related to age, because little difference was found between elderly participants wearing dentures during mastication and young healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

Chuhuaicura

Días

Arias

et al. 2019

International Dental Journal

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Introduction A relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. Materials and methods A systematic review was performed according to the ‘Preferred Reporting Items for Systematic Reviews and Meta‐Analyses’ (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients. Results Nine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity. Conclusion Masticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.

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“…Many studies have reported that occlusal trauma (OT) can cause numerous destructive biological effects on the stomatognathic system, specifically in the pulp tissue, the periodontium, the alveolar bone, the masticatory muscle, the temporo-mandibular joint and even on the central nervous system [1,3,4]. The occlusal trauma has effects on the sensitivity and the mode of conduction of neuronal impulses from the dento-alveolar complex to the primary sensitive neurons.…”

mentioning

confidence: 99%

Consequences of Dental Occlusion Enhancement by Means of Metal Crowns on the Animal Model

Ispas¹,

Craciun²,

Lascu³

et al. 2019

Rev. Chim.

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The purpose of this study was to determine whether there is a correlation between induced occlusal trauma and the occurrence of oxidative stress in the hippocampus. Twenty Wistar rats were randomized into three experimental groups and one control group. Animals in the experimental group were cemented modified crowns on molars to induce occlusal trauma in 7, 14 and 30 days. To evaluate the oxidative stress, blood was drawn from the hippocampus at 7, 14 and 30 day intervals. Oxidative stress was evaluated using the following specific tests: determination of plasma malondialdehyde and serum glutathione values. The results of the study demonstrate that malocclusion experienced by raising the vertical dimension in rats resulted in significant reductions in antioxidants and increase level of free radicals.

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Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice

Cited by 24 publications

References 33 publications

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chewing Maintains Hippocampus-Dependent Cognitive Function

Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

Consequences of Dental Occlusion Enhancement by Means of Metal Crowns on the Animal Model

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