“…The surgical technique has been described by our group in a previous manuscript [23] and briefly consists of anchoring the plastic tip of each positioned electrode to the underlying muscular fascia with non-adsorbable sutures and of tunnelling the connection cables to the subcostal region, where the internal pulse generators (IPGs) are placed. Clinical indications to ONS are: CCH [24], hemicrania continua [25], transformed migraine [26,27], cervicogenic headaches [28] and occipital neuralgia [29,30]. Apart from the latter two indications, the use of ONS for the different types of cranial neuralgias is justified by the presence of a functional unit known as the ''trigemino-cervical complex'', which comprises the trigeminal nucleus caudalis and the first two cervical spinal myelomeres and in which nociceptive informations of both the suboccipital and trigeminal territory converge, thus stimulation of the greater occipital nerve could modulate the central nociceptive trigeminal neurons through peripheral cervical afferents [31].…”