Occipital Nerve Stimulation

Slavin, Konstantin V.; Isagulyan, E D; Gomez, Christy; Yin, Dali

doi:10.1016/j.nec.2018.12.004

Cited by 27 publications

(26 citation statements)

References 55 publications

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“…There is limited research on its use in the treatment of ON, but it has proven efficacious in treatment of other conditions. In a recent analysis of its use in ON, there was a Level III recommendation that in 76 patients the majority had a favorable long-term outcome [53].…”

Section: Peripheral Nerve Stimulationmentioning

confidence: 99%

A Review of the Recent Findings in Minimally Invasive Treatment Options for the Management of Occipital Neuralgia

et al. 2020

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Section: Peripheral Nerve Stimulationmentioning

confidence: 99%

A Review of the Recent Findings in Minimally Invasive Treatment Options for the Management of Occipital Neuralgia

et al. 2020

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“…Remarkably, this apparently unchanged response to GON stimulation was ensued by different effects on succeeding responses to facial tactile stimuli depending on whether IoN is, or is not injured, as discussed below. A conditioning stimulus to GON increases the TCC response to vibrissal stimulation in controls, but reduces it in CCI-IoN cases Despite the expanding use of GON stimulation to treat a variety of craniofacial pain disorders (reviewed in [89,90]), scarce attention has been paid to the basic neural mechanisms that may underlie this connection. Early electrophysiological and anatomical findings, mostly in cats, showed a convergence of GON and trigeminal afferents on upper cervical or medullary dorsal horn (see [27]).…”

Section: Responses In Tcc To Gon and Vibrissal Stimulation Are Differmentioning

confidence: 99%

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

et al. 2020

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Background: Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipital sensory afferents in the 'trigeminocervical complex' (TCC) from cutaneous, muscular, dural, and visceral sources is a key mechanism for the input-induced central sensitization that may underlie the altered nociception. Both excitatory (glutamatergic) and inhibitory (GABAergic and glycinergic) mechanisms are involved in modulating nociception in the spinal and medullary dorsal horn neurons, but the mechanisms by which nerve stimulation effects occur are unclear. This study was aimed at investigating the acute effects of electrical stimulation of the greater occipital nerve (GON) on the responses of neurons in the TCC to the mechanical stimulation of the vibrissal pad. Methods: Adult male Wistar rats were used. Neuronal recordings were obtained in laminae II-IV in the TCC in control, sham and infraorbital chronic constriction injury (CCI-IoN) animals. The GON was isolated and electrically stimulated. Responses to the stimulation of vibrissae by brief air pulses were analyzed before and after GON stimulation. In order to understand the role of the neurotransmitters involved, specific receptor blockers of NMDA (AP-5), GABA A (bicuculline, Bic) and Glycine (strychnine, Str) were applied locally. Results: GON stimulation produced a facilitation of the response to light facial mechanical stimuli in controls, and an inhibition in CCI-IoN cases. AP-5 reduced responses to GON and vibrissal stimulation and blocked the facilitation of GON on vibrissal responses found in controls. The application of Bic or Str significantly reduced the facilitatory effect of GON stimulation on the response to vibrissal stimulation in controls. However, the opposite effect was found when GABAergic or Glycinergic transmission was prevented in CCI-IoN cases.

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“…Despite the expanding use of GON stimulation to treat a variety of craniofacial pain disorders (reviewed in [89,90]), scarce attention has been paid to the basic neural mechanisms that may underlie this connection. Early electrophysiological and anatomical ndings, mostly in cats, showed a convergence of GON and trigeminal afferents on upper cervical or medullary dorsal horn (see [27]).…”

Section: Responses In Tcc To Gon and Vibrissal Stimulation Are Differmentioning

confidence: 99%

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

García-Magro

Negredo

Martín

et al. 2020

Preprint

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Background: Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipital sensory afferents in the ‘trigeminocervical complex’ (TCC) from cutaneous, muscular, dural, and visceral sources is a key mechanism for the input-induced central sensitization that may underlie the altered nociception. Both excitatory (glutamatergic) and inhibitory (GABAergic and glycinergic) mechanisms are involved in modulating nociception in the spinal and medullary dorsal horn neurons, but the mechanisms by which nerve stimulation effects occur are unclear. This study was aimed at investigating the acute effects of electrical stimulation of the greater occipital nerve (GON) on the responses of neurons in the TCC to the mechanical stimulation of the vibrissal pad.Methods: Adult male Wistar rats were used. Neuronal recordings were obtained in laminae II-IV in the TCC in control, sham and infraorbital chronic constriction injury (CCI-IoN) animals. The GON was isolated and electrically stimulated. Responses to the stimulation of vibrissae by brief air pulses were analyzed before and after GON stimulation. In order to understand the role of the neurotransmitters involved, specific receptor blockers of NMDA (AP-5), GABAA (bicuculline, Bic) and Glycine (strychnine, Str) were applied locally.Results: GON stimulation produced a facilitation of the response to light facial mechanical stimuli in controls, and an inhibition in CCI-IoN cases. AP-5 reduced responses to GON and vibrissal stimulation and blocked the facilitation of GON on vibrissal responses found in controls. The application of Bic or Str significantly reduced the facilitatory effect of GON stimulation on the response to vibrissal stimulation in controls. However, the opposite effect was found when GABAergic or Glycinergic transmission was prevented in CCI-IoN cases.Conclusions: GON stimulation modulates the responses of TCC neurons to light mechanical input from the face in opposite directions in controls and under CCI-IoN. This modulation is mediated by GABAergic and Glycinergic mechanisms. These results will help to elucidate the neural mechanisms underlying the effectiveness of nerve stimulation in controlling painful craniofacial disorders, and may be instrumental in identifying new therapeutic targets for their prevention and treatment.

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Occipital Nerve Stimulation

Cited by 27 publications

References 55 publications

A Review of the Recent Findings in Minimally Invasive Treatment Options for the Management of Occipital Neuralgia

A Review of the Recent Findings in Minimally Invasive Treatment Options for the Management of Occipital Neuralgia

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

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