Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD

Lobotesis, Kyriakos; Fenwick, John D.; Phipps, Andrew J.; Ryman, Ann; Swann, Alan; Ballard, Clive; McKeith, Ian G.; O’Brien, John

doi:10.1212/wnl.56.5.643

Cited by 371 publications

(254 citation statements)

References 34 publications

(31 reference statements)

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“…The studies showed a variable DLB sensitivity and AD specificity of 65% to 85% and 71% to 87%, respectively. 10,11,13,14,33 Studies using 18 F-fluorodeoxyglucose positron emission tomography have largely shown greater diagnostic accuracy than perfusion SPECT in distinguishing DLB from AD. 34,35 The DLB sensitivity and AD specificity are quoted as ranging from 86% to 92% and from 80% to 92%, respectively, although such results should be viewed with caution because of the relatively small samples studied and indeed larger more recent AD DLB positron emission tomography study was found to be less accurate (sensitivity 64%, specificity 65%).…”

Section: Discussionmentioning

confidence: 99%

Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Colloby

Taylor

Davison

et al. 2013

J Cereb Blood Flow Metab

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We examined 99m Tc-exametazime brain blood flow single-photon emission computed tomography (SPECT) images using a spatial covariance analysis (SCA) approach to assess its diagnostic value in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). Voxel SCA was simultaneously applied to a set of preprocessed images (AD, n ¼ 40; DLB, n ¼ 26), generating a series of eigenimages representing common intercorrelated voxels in AD and DLB. Linear regression derived a spatial covariance pattern (SCP) that discriminated DLB from AD. To investigate the diagnostic value of the model SCP, the SCP was validated by applying it to a second, independent, AD and DLB cohort (AD, n ¼ 34; DLB, n ¼ 29). Mean SCP expressions differed between AD and DLB (F 1,64 ¼ 36.2, Po0.001) with good diagnostic accuracy (receiver operating characteristic (ROC) curve area 0.87, sensitivity 81%, specificity 88%). Forward application of the model SCP to the independent cohort revealed similar differences between groups (F 1,61 ¼ 38.4, Po0.001), also with good diagnostic accuracy (ROC 0.86, sensitivity 80%, specificity 80%). Multivariate analysis of blood flow SPECT data appears to be robust and shows good diagnostic accuracy in two independent cohorts for distinguishing DLB from AD.

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Section: Discussionmentioning

confidence: 99%

Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Colloby

Taylor

Davison

et al. 2013

J Cereb Blood Flow Metab

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“…Brain glucose metabolism studies, for example, indicate that hypometabolism of the primary visual cortex (area V1) is more marked in DLB, whereas reductions in the posterior/temporal cortex, posterior cingulate gyrus, and frontal cortex occur in both AD and DLB [122]. Studies of regional cerebral blood flow (rCBF) report similar results, i.e., occipital hyperperfusion may be more frequent in DLB [110]. …”

Section: Anatomymentioning

confidence: 97%

Can neurodegenerative disease be defined by four ‘primary determinants’: anatomy, cells, molecules, and morphology?

Armstrong

2016

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A b s t r a c t , the anatomical pathways affected by the disease ('anatomy'), the cell populations affected ('cells'), the molecular pathology of 'signature' pathological lesions ('molecules'), and the morphological types of neurodegeneration ('morphology'). This review first discusses the limitations of existing classificatory systems and second provides evidence that the four primary determinants could be used as axes to define all cases of neurodegenerative disease.To illustrate the methodology, the primary determinants were applied to the study of a group of closely related tauopathy cases and to heterogeneity within frontotemporal lobar degeneration with .

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“…Studies comparing AD and DLB patients have pinpointed some differences in cognitive performance: memory impairment is less severe in DLB than AD (e.g., Calderon et al, 2001;Salmon et al, 1996;Shimomura et al, 1998), while visual-perceptual and spatial abilities are more impaired (e.g., Ala et al, 2001;Calderon et al, 2001;Gnanalingham et al, 1997;Salmon et al, 1996). Consistent with the neuropsychological profile, functional imaging studies show that patients with DLB more commonly have reduced perfusion in the occipital lobes than AD patients (Ishii et al, 1999;Lobotesis et al, 2001).…”

Section: Introductionmentioning

confidence: 93%

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

Laws

Crawford

Gnoato

et al. 2007

J. Inter. Neuropsych. Soc.

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Although semantic memory impairment is well documented in patients with dementia of the Alzheimer's type, questions remain as to whether the deficit extends to other forms of dementia and whether it differentially affects different domains of knowledge. We examined category naming on two tasks (picture naming and naming-to-description) in patients with Alzheimer's disease (AD: n 5 11), Lewy body dementia (DLB: n 5 11) and healthy elderly matched controls (n 5 22). The DLB and AD groups showed significantly worse naming on both tasks, although the AD patients were more impaired than the DLB patients. Like some AD patients, some DLB patients showed evidence of category-specific naming deficits, and strikingly, all 25 significant category dissociations were for living things. The latter finding accords with the preponderance of living deficits previously documented for AD patients, but extends this finding to DLB patients. The implications of this category bias is discussed in relation to relevant models of category specificity. (JINS, 2007, 13, 401-409.)

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Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD

Cited by 371 publications

References 34 publications

Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Can neurodegenerative disease be defined by four ‘primary determinants’: anatomy, cells, molecules, and morphology?

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

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Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD

Cited by 371 publications

References 34 publications

Multivariate Spatial Covariance Analysis of 99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Multivariate Spatial Covariance Analysis of 99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Can neurodegenerative disease be defined by four ‘primary determinants’: anatomy, cells, molecules, and morphology?

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

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Product

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Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis

Multivariate Spatial Covariance Analysis of ^99MTc-Exametazime SPECT Images in Dementia with Lewy Bodies and Alzheimer'S Disease: Utility in Differential Diagnosis