Occipital gamma response to auditory stimulation in patients with schizophrenia

Başar-Eroğlu, Canan; Mathes, Birgit; Brand, Andreas; Schmiedt-Fehr, Christina

doi:10.1016/j.ijpsycho.2010.10.011

Cited by 18 publications

(10 citation statements)

References 55 publications

(76 reference statements)

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“…Altogether, these studies are in agreement the findings of Hoffman et al (1999), who suggested that the core schizophrenic deficit is not centered on attentional-perceptual cognitive processes, but rather verbal working memory (and, hence, difficulties with syntactic computation, given the “chunking” nature of linguistic phrase structure building; see Narita, 2014), mediated by oscillations generated in the hippocampus and left temporal regions (Murphy, 2015a). Başar-Eroğlu et al (2011) also documented reduced anterior α in response to simple auditory input, suggesting less efficient processing power.…”

Section: From Brain Rhythmicity To Language Deficits In Schizophreniamentioning

confidence: 98%

Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach

Murphy

Benítez‐Burraco

2016

Front. Hum. Neurosci.

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Schizophrenia is characterized by marked language deficits, but it is not clear how these deficits arise from the alteration of genes related to the disease. The goal of this paper is to aid the bridging of the gap between genes and schizophrenia and, ultimately, give support to the view that the abnormal presentation of language in this condition is heavily rooted in the evolutionary processes that brought about modern language. To that end we will focus on how the schizophrenic brain processes language and, particularly, on its distinctive oscillatory profile during language processing. Additionally, we will show that candidate genes for schizophrenia are overrepresented among the set of genes that are believed to be important for the evolution of the human faculty of language. These genes crucially include (and are related to) genes involved in brain rhythmicity. We will claim that this translational effort and the links we uncover may help develop an understanding of language evolution, along with the etiology of schizophrenia, its clinical/linguistic profile, and its high prevalence among modern populations.

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Section: From Brain Rhythmicity To Language Deficits In Schizophreniamentioning

confidence: 98%

Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach

Murphy

Benítez‐Burraco

2016

Front. Hum. Neurosci.

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“…Various cortical and subcortical abnormalities have been associated with SZ, 8, 9, 10, 11, 12, 13, 14, 15 as well as alterations at the level of morphology, 16, 17 neurotransmitter systems 18, 19 and neurophysiology. 20, 21, 22, 23 Additionally, polymorphisms in multiple genes have been identified as risk factors for disease development through genome-wide association studies. 24, 25 …”

Section: Introductionmentioning

confidence: 99%

Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia

et al. 2013

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The underlying pathology of schizophrenia (SZ) is likely as heterogeneous as its symptomatology. A variety of cortical and subcortical regions, including the prefrontal cortex, have been implicated in its pathology, and a number of genes have been identified as risk factors for disease development. We used in situ hybridization (ISH) to examine the expression of 58 genes in the dorsolateral prefrontal cortex (DLPFC, comprised of Brodmann areas 9 and 46) from 19 individuals with a premorbid diagnosis of SZ and 33 control individuals. Genes were selected based on: (1) previous identification as risk factors for SZ; (2) cell type markers or (3) laminar markers. Cell density and staining intensity were compared in the DLPFC, as well as separately in Brodmann areas 9 and 46. The expression patterns of a variety of genes, many of which are associated with the GABAergic system, were altered in SZ when compared with controls. Additional genes, including C8orf79 and NR4A2, showed alterations in cell density or staining intensity between the groups, highlighting the need for additional studies. Alterations were, with only a few exceptions, limited to Brodmann area 9, suggesting regional specificity of pathology in the DLPFC. Our results agree with previous studies on the GABAergic involvement in SZ, and suggest that areas 9 and 46 may be differentially affected in the disease. This study also highlights additional genes that may be altered in SZ, and indicates that these potentially interesting genes can be identified by ISH and high-throughput image analysis techniques.

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“…Dysfunction of coherent synchrony in cell assemblies of varying complexity may be a core deficit in schizophrenia. It is not clear if such deficits in local circuit function lead to an overall reduction of gamma power, reduced time-locking of gamma band response which leads to apparent power reduction following averaging (Başar-Eroğlu et al, 2011), or some combination of both defects.…”

Section: 4 Discussionmentioning

confidence: 99%

“…Leicht et al (2010) found both reduced evoked power and PLF of EAGBR using wavelets in 90 patients versus 90 healthy comparison subjects. A recent report by Başar-Eroğlu et al (2011) compared averaged and single trial responses to ignored single tone trains and to attended oddball trains. They reported that the averaged EAGBR did not differ between 10 patients and 10 controls, but that EAGBR power was increased in patients on individual trials over occipital areas.…”

Section: 1 Introductionmentioning

confidence: 99%

Early auditory gamma band response abnormalities in first hospitalized schizophrenia

Taylor

McCarley

Salisbury

2013

Supplements to Clinical Neurophysiology

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Background Abnormalities in coherent cortical circuit functioning, reflected in gamma band activity (~40 Hz), may be a core deficit in schizophrenia. The early auditory gamma band response (EAGBR) is a neurophysiologically simple probe of circuit functioning in primary auditory cortex. We examined the EAGBR in first hospitalized schizophrenia to assess whether it was reduced at first hospitalization. Method Wavelet evoked power and intertrial phase locking of the EAGBR at Fz to standard tones during an oddball target detection task were examined in 28 first hospitalized schizophrenia patients (10 female) and 44 control subjects (17 female). Results At first hospitalization EAGBR trial-to-trial phase locking and evoked power were significantly reduced in patients. Although reduced overall in patients, greater total symptoms were significantly associated with greater gamma phase locking and power. Additionally, greater EAGBR power was marginally associated with greater positive factor scores, hallucinations, and thinking disturbance. Conclusions Abnormalities of gamma band functioning in local auditory sensory circuits are present in schizophrenia at first hospitalization further evidence that basic sensory processes are impaired in schizophrenia. It remains to be determined whether the EAGBR becomes permanently impaired with disease progression, and if its reduction is specific to schizophrenia.

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Occipital gamma response to auditory stimulation in patients with schizophrenia

Cited by 18 publications

References 55 publications

Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach

Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach

Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia

Early auditory gamma band response abnormalities in first hospitalized schizophrenia

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