Occasional human infestations by feral pigeons' ectoparasites: Two case reports

Akhoundi, Mohammad; Brun, Sophie; Marteau, Anthony; Debédat, Jean; Romdhane, H. Ben; Izri, Arezki

doi:10.1002/ccr3.2764

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…Using an approach combining a cut-off value of E < 10 − 05 , transcript evidence, phylogenetics and functional domain conservation in multigene families, we were able to identify a single protein or a small number (< 8) of related proteins for 21 allergen groups in PRM. A further eleven allergen groups (1, 3, 6, 8, 9, 15, 18, 28, 29, 33, 39, and) had expanded sets of related genes in PRM, which belonged to large multigene families: cysteine and serine proteases, GSTs, chitin binding/chitinase proteins, HSPs, cyclophilins, and structural components alpha tubulin 1A and troponin C. This situation was comparable to the expanded allergen group homologues seen in P. ovis (groups 8, 9, 15, 27, 28, 29 and 33) and E. maynei (groups 1,3,6,9,15,18,27,28,29) [12,73] and is representative of the difficulty in identifying the true orthologous allergen proteins using an in silico approach alone. Identifying the allergen IgE targets of sensitised humans and poultry would be useful in fully comprehending the allergen repertoire of PRM.…”

Section: Discussionmentioning

confidence: 74%

“…Panel b shows 6 superclusters within this network which were highly expressed in single stages where "E", "L", "P", "D" "AM" and "AF" represent transcripts that have high expression in eggs, larvae, protonymphs, deutonymphs, adult males and adult females respectively. Panel c shows the mean transcript per million (TPM) data for all D. gallinae transcripts in each of the stage-enriched clusters (Superclusters 1-6) 2725 (1) Adult Males (AM) 292 (13) Deutonymphs (D) 295 (12) Protonymphs (P) 165 (17) Larvae (L) 1907 (3) Eggs (E) 1052 (4) E/AF 2480 (2) E/D 178 (16) E/L 743 (6) L/AF 688 (8) L/AM 201 (15) L/D 382 (11) L/D/AF 236 (14) P/D 695 (7) D/AF 899 (5) D/AF/AM 414 (10) D/AM 593 (9) Genes most abundant in multiple life stages and sexes…”

Section: Assessment Of the Most Abundantly Expressed Genes For Each Pmentioning

confidence: 99%

“…The recognition and reporting of gamasoidosis caused by PRM is increasing in urban areas of Europe (e.g. [1,34]), however human cases in workers within the commercial poultry sector often go unreported. A survey of Italian poultry workers indicate that approximately 20% of workers experience pruritic dermatitis attributed to contact with PRM and suggested PRM should be recognised as an occupational hazard in the poultry sector [14].…”

Section: Introductionmentioning

confidence: 99%

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Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle

et al. 2021

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Background The blood feeding poultry red mite (PRM), Dermanyssus gallinae, causes substantial economic damage to the egg laying industry worldwide, and is a serious welfare concern for laying hens and poultry house workers. In this study we have investigated the temporal gene expression across the 6 stages/sexes (egg, larvae, protonymph and deutonymph, adult male and adult female) of this neglected parasite in order to understand the temporal expression associated with development, parasitic lifestyle, reproduction and allergen expression. Results RNA-seq transcript data for the 6 stages were mapped to the PRM genome creating a publicly available gene expression atlas (on the OrcAE platform in conjunction with the PRM genome). Network analysis and clustering of stage-enriched gene expression in PRM resulted in 17 superclusters with stage-specific or multi-stage expression profiles. The 6 stage specific superclusters were clearly demarked from each other and the adult female supercluster contained the most stage specific transcripts (2725), whilst the protonymph supercluster the fewest (165). Fifteen pairwise comparisons performed between the different stages resulted in a total of 6025 Differentially Expressed Genes (DEGs) (P > 0.99). These data were evaluated alongside a Venn/Euler analysis of the top 100 most abundant genes in each stage. An expanded set of cuticle proteins and enzymes (chitinase and metallocarboxypeptidases) were identified in larvae and underpin cuticle formation and ecdysis to the protonymph stage. Two mucin/peritrophic-A salivary proteins (DEGAL6771g00070, DEGAL6824g00220) were highly expressed in the blood-feeding stages, indicating peritrophic membrane formation during feeding. Reproduction-associated vitellogenins were the most abundant transcripts in adult females whilst, in adult males, an expanded set of serine and cysteine proteinases and an epididymal protein (DEGAL6668g00010) were highly abundant. Assessment of the expression patterns of putative homologues of 32 allergen groups from house dust mites indicated a bias in their expression towards the non-feeding larval stage of PRM. Conclusions This study is the first evaluation of temporal gene expression across all stages of PRM and has provided insight into developmental, feeding, reproduction and survival strategies employed by this mite. The publicly available PRM resource on OrcAE offers a valuable tool for researchers investigating the biology and novel interventions of this parasite.

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Section: Discussionmentioning

confidence: 74%

Section: Assessment Of the Most Abundantly Expressed Genes For Each Pmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle

et al. 2021

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“…After the reports listed by Cafiero et al [12], another eight urban cases of dermanyssosis in humans in Europe have been recorded, i.e., two cases in France [13], one case in Greece [14], two cases in Hungary [15] and three in Italy [16]. To date, over 240 clinical cases of urban infestations caused by D. gallinae have been reported.…”

Section: Discussionmentioning

confidence: 96%

Dermanyssosis in the Urban Context: When the One Health Paradigm Is Put into Practice

et al. 2022

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Poultry red mites (Dermanyssus gallinae) are primarily ectoparasites of laying hens but also parasitize synanthropic birds in urban contexts. This mite can occasionally attack mammals, including humans, and cause mild to severe dermatitis. Attacks by zoonotic Mesostigmata mites are currently an increasing but still neglected problem of urban life. The authors present two cases of dermanyssosis involving two health workers at a hospital, linked to air conditioning outdoor units colonized by pigeons. Videos that describe the environmental contamination by D. gallinae and show where the infestation originated are presented. In addition, the authors update the literature of all urban cases, which, to date, reports over 240 clinical cases, mostly in private homes but also in public buildings. Dermatitis due to these mites is often unrecognized and, therefore, misdiagnosed. This report describes how the two cases herein reported were rapidly resolved thanks to the close cooperation between veterinary parasitologists and allergologists. It is crucial to raise awareness of the problem among general practitioners and specialists. In addition, the authors suggest a reconsideration of urban architectural choices that increase the public health risk posed by dermanyssosis and other diseases related to synanthropic birds.

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“…Other cases of deceiving citations are due to a kind of “Chinese whispers” game from author to author. A putative association between D. gallinae and some protozoa and filariae has been reported in several papers [ 4 , 23 ]. Nonetheless, going back to the origin of this information, Valiente Moro et al [ 24 ] claimed in their review that the potential relationship of those pathogens was with Ornithonyssus bacoti [ 25 , 26 ] and not D. gallinae .…”

Section: Inaccessibility and Misinterpretation Of Some Experimental Studies: Literature Or Legend?mentioning

confidence: 98%

Dermanyssus gallinae: the long journey of the poultry red mite to become a vector

et al. 2022

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The possibility that Dermanyssus gallinae, the poultry red mite, could act as a vector of infectious disease-causing pathogens has always intrigued researchers and worried commercial chicken farmers, as has its ubiquitous distribution. For decades, studies have been carried out which suggest that there is an association between a wide range of pathogens and D. gallinae, with the transmission of some of these pathogens mediated by D. gallinae as vector. The latter include the avian pathogenic Escherichia coli (APEC), Salmonella enterica serovars Enteritidis and Gallinarum and influenza virus. Several approaches have been adopted to investigate the relationship between D. gallinae and pathogens. In this comprehensive review, we critically describe available strategies and methods currently available for conducting trials, as well as outcomes, analyzing their possible strengths and weaknesses, with the aim to provide researchers with useful tools for correctly approach the study of the vectorial role of D. gallinae. Graphical Abstract

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Occasional human infestations by feral pigeons' ectoparasites: Two case reports

Cited by 3 publications

References 20 publications

Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle

Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle

Dermanyssosis in the Urban Context: When the One Health Paradigm Is Put into Practice

Dermanyssus gallinae: the long journey of the poultry red mite to become a vector

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