OC17.08: What is the current ophthalmic artery Doppler waveform morphology in women who had pre‐eclampsia one decade ago?

Abstract

of non-SGA gestational diabetes (GDM) pregnancies. We aimed to examine whether CPR can identify GDM fetuses that are not growth restricted but are at increased risk of adverse neonatal outcomes. Methods: A prospective single centre observational study. Included were women with non-anomalous singleton pregnancies and GDM. Women with pre-existing diabetes, hypertension or suspected SGA were excluded. Fetal biometry, biophysical profile and blinded CPR (MCA PI/UA PI) measurement was performed every 2-4 weeks. Outcomes were analysed based on CPR measurement closest to delivery, compared between last CPR above or below 10%. Primary outcome was a composite, consisting of at least one of the following: stillbirth, Caesarean section due to suspected fetal distress, 5-minute Apgar < 7, cord arterial PH < 7, hypoxic ischemic encephalopathy, NICU admission > 24 hours. Results: Of 281 eligible patients, 257 (91.5%) had last CPR > 10% (Group A) and 24 (8.5%) had last CPR < 10% (Group B), at a mean gestational age of 36 weeks, (p = 0.261). Maternal age, parity, gravity, BMI were similar in both groups. There was no significant difference in gestational age at delivery (p = 0.73). Birthweight and birthweight percentile were significantly lower among CPR < 10% group. No difference was found in the rate of the primary outcome, which occurred in 18 (7%) of group A and 2 (8.3%) of group B (p = 0.684). Newborns in group B had more Hypoglycemia than controls. In a multivariate analysis lower CPR was found to be significantly associated with the risk of neonatal hypoglycemia (OR 3.182 95%CI 1.223-8.280). Conclusions: CPR was not associated with composite adverse neonatal outcome in non-SGA GDM pregnancies. Further elucidation of association of low CPR and neonatal hypoglycemia is needed. OC17.06 Maternal cardiac function in women at high-risk for pre-eclampsia treated with 150mg aspirin or placebo: an observational study