OC-123 Obesity drives radioresistance and enhances genomic instability in oesophageal adenocarcinoma

Mongan, Ann; Lynam‐Lennon, Niamh; Maher, Stephen G.; Pidgeon, Graham P.; O’Sullivan, Janet; Reynolds, John V.

doi:10.1136/gutjnl-2012-302514a.123

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, abnormal body mass index values are also considered a prognostic factor for cervical cancer, as underweight and overweight/obese patients have significantly poorer progression-free survival than patients with normal body mass index values (median 7.6 months vs 25.0 months, p=0.01; 20.3 months vs 25.0 months, p=0.03) 33. Obesity may promote malignant transformation via several pathophysiological mechanisms, as well as radioresistance 34 35…”

Section: Discussionmentioning

confidence: 99%

Outcomes of pre-operative brachytherapy followed by hysterectomy for early cervical cancer

Bataille

Escande

Tinier

et al. 2019

Int J Gynecol Cancer

View full text Add to dashboard Cite

ObjectiveThe standard of care for early cervical cancer is radical hysterectomy; however, consideration of pre-operative brachytherapy has been explored. We report our experience using pre-operative brachytherapy plus Wertheim-type hysterectomy to treat early stage cervical cancer.MethodsThis single-center study evaluated consecutive patients with histologically proven node-negative early stage cervical cancer (International Federation of Gynecology and Obstetrics 2009 stage IB1–IIB) that was treated using pre-operative brachytherapy and hysterectomy. Pre-brachytherapy staging was performed using magnetic resonance imaging (MRI) and pelvic lymph node assessment was performed using lymphadenectomy. The tumor and cervical tissues were treated using brachytherapy (total dose 60 Gy) followed by Wertheim-type hysterectomy. The study included patients from January 2000 to December 2013.ResultsA total of 80 patients completed a median follow-up of 6.7 years (range 5.4–8.5). The surgical specimens revealed a pathological complete response for 61 patients (76%). Patients with incomplete responses generally had less than 1 cm residual tumor at the cervix, and only one patient had lymphovascular space involvement. The estimated 5-year rates were 88% for overall survival (95% CI 78% to 94%) and 82% for disease-free survival (95% CI 71% to 89%). Toxicities were generally mild-to-moderate, including 26 cases (33%) of grade 2 late toxicity and 10 cases (13%) of grade 3 late toxicity. Univariate analyses revealed that poor disease-free survival was associated with overweight status (≥25 kg/m2, HR 3.05, 95% CI 1.20 to 7.76, p=0.019) and MRI tumor size >3 cm (HR 3.05, 95% CI 1.23 to 7.51, p=0.016).ConclusionsPre-operative brachytherapy followed by Wertheim-type hysterectomy may be safe and effective for early stage cervical cancer, although poorer outcomes were associated with overweight status and MRI tumor size >3 cm.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcomes of pre-operative brachytherapy followed by hysterectomy for early cervical cancer

Bataille

Escande

Tinier

et al. 2019

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

“…Obesity is a major risk factor for acute toxicity in virtually all types of anticancer treatments [39][40][41]. This adverse effect is most likely related to the higher dose of the genotoxic agent that is required to achieve the desired effect in larger patients.…”

Section: Individual Capacity For Dna Repairmentioning

confidence: 99%

Some problems and errors in cytogenetic biodosimetry

Mosse

Kilchevsky

Nikolova

et al. 2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2-3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly measured as chromosome aberration rates) in different individuals. There is significant genetic component in individual radiosensitivity. It is related to carriership of variant alleles of various single-nucleotide polymorphisms (most of these in genes coding for proteins functioning in DNA damage identification and repair); carriership of a different number of alleles producing cumulative effects; amplification of gene copies coding for proteins responsible for radioresistance, mobile genetic elements and others. Among the other factors influencing individual radioresistance are: the radioadaptive response; the bystander effect; the levels of endogenous substances with radioprotective and antimutagenic properties and environmental factors such as lifestyle and diet, physical activity, psychoemotional state, hormonal state, certain drugs, infections and others. These factors may have radioprotective or sensibilizing effects. Apparently, there are too many factors that may significantly modulate the biological effects of ionizing radiation. Thus, conventional methodologies for biodosimetry (specifically, cytogenetic methods) may produce significant errors if personal traits that may affect radioresistance are not accounted for.

show abstract

OC-123 Obesity drives radioresistance and enhances genomic instability in oesophageal adenocarcinoma

Cited by 2 publications

References 0 publications

Outcomes of pre-operative brachytherapy followed by hysterectomy for early cervical cancer

Outcomes of pre-operative brachytherapy followed by hysterectomy for early cervical cancer

Some problems and errors in cytogenetic biodosimetry

Contact Info

Product

Resources

About