OC-066 Economic and quality-of-life burden of moderate-to-severe irritable bowel syndrome with constipation (ibs-c) in the uk: the ibis-c study

Yiannakou, Yan; Eugenicos, Maria; Sanders, DS; Emmanuel, Anton; Whorwell, Peter J.; Butt, Fauzia; Bridger, Stephen; Arebi, Naila; Millar, A. J. W.; Kaushik, Vishal; Rance, M; Mackinnon, J; Bertsch, Jordan; Fortea, J; Tack, Jan

doi:10.1136/gutjnl-2015-309861.66

Cited by 3 publications

(4 citation statements)

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“…5 This often results in a reduction of health-related quality of life (QOL), [6][7][8][9][10][11][12] increased healthcare costs 6,11,[13][14][15] and absenteeism at work. 6,11 Gut-directed hypnotherapy, a gut-specific behavioural treatment, is one of the few treatments with an evidence base for refractory IBS 16 and is recommended in clinical guidelines when patients have not responded to medical treatments for at least 12 months. 17,18 Gut-directed hypnotherapy aims to induce a state of relaxation and suggestibility, which allows the patient to take control of their gut by making physiological and psychological changes.…”

Section: Introductionmentioning

confidence: 99%

“…3 Unfortunately, conventional treatment approaches have limited efficacy particularly in those with severe, refractory symptoms, 4 which affect approximately 25% of patients. 5 This often results in a reduction of health-related quality of life (QOL), [6][7][8][9][10][11][12] increased healthcare costs 6,11,[13][14][15] and absenteeism at work. 6,11 Gut-directed hypnotherapy, a gut-specific behavioural treatment, is one of the few treatments with an evidence base for refractory IBS 16 and is recommended in clinical guidelines when patients have not responded to medical treatments for at least 12 months.…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, conventional treatment approaches have limited efficacy particularly in those with severe, refractory symptoms, 4 which affect approximately 25% of patients 5 . This often results in a reduction of health‐related quality of life (QOL), 6–12 increased healthcare costs 6,11,13–15 and absenteeism at work 6,11 …”

Section: Introductionmentioning

confidence: 99%

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Clinical trial: predictive factors for response to gut‐directed hypnotherapy for refractory irritable bowel syndrome, a post hoc analysis

Devenney,

Hasan,

Morris

et al. 2023

Aliment Pharmacol Ther

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SummaryBackgroundGut‐directed hypnotherapy is effective for patients with irritable bowel syndrome (IBS). Despite its considerable evidence base, gut‐directed hypnotherapy is not widely available and remains a limited resource. This emphasises the need to select patients who are most likely to benefit.AimTo determine whether baseline patient characteristics were predictive of response to gut‐directed hypnotherapy in patients with IBSMethodsWe conducted a secondary analysis of outcomes of 448 patients with refractory Rome III IBS who participated in a randomised study confirming non‐inferiority of 6 compared to 12 sessions of gut‐directed hypnotherapy. We compared baseline patient characteristics, including age, sex, IBS subtype, quality of life and IBS‐Symptom Severity Scale (IBS‐SSS), non‐colonic symptom score and Hospital Anxiety and Depression (HAD) score between responders and non‐responders. We defined response as ≥50‐point decrease in IBS‐SSS or ≥30% reduction in pain severity scores.ResultsOverall, 76.3% achieved ≥50‐point decrease in IBS‐SSS. Responders had a higher baseline non‐colonic symptom score (p = 0.005). Those who achieved ≥30% improvement in abdominal pain scores (59.8%) had higher baseline IBS‐SSS (p = 0.03), and lower baseline HAD‐depression score (p = 0.012). Fifty‐four patients (12%) dropped out of gut‐directed hypnotherapy. Compared to completers, dropouts had higher baseline HAD‐anxiety score (p = 0.034).ConclusionsThese data suggest that patients with a higher burden of gastrointestinal and extraintestinal symptoms are most likely to benefit from gut‐specific behavioural intervention for refractory IBS. Clinical assessment of gastrointestinal, somatic and psychological symptom profiles may play a role in selecting patients for gut‐directed hypnotherapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical trial: predictive factors for response to gut‐directed hypnotherapy for refractory irritable bowel syndrome, a post hoc analysis

Devenney,

Hasan,

Morris

et al. 2023

Aliment Pharmacol Ther

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“…For example, Prucalopride, for chronic constipation and usually prescribed in secondary care, had a response rate of 28% [14]. Even with the best education and support TAI will not work for all patients [15]. However, PERSPECTIVE has demonstrated a very…”

Section: Discussionmentioning

confidence: 99%

Transanal Irrigation for the Management of Functional Bowel Disorders: An Observational Study

2022

Int J Nurs Health Care Res

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Aim:The aim of the PERSPECTIVE * study was to examine the burden of a wide range of functional bowel disorders (FBDs) on quality of life, work productivity and healthcare utilisation and to explore patients' perceptions of using transanal irrigation (TAI) to manage these conditions. This paper reports the findings related to TAI. Method: This large observational study utilised two existing cohorts of people -the ContactME-IBS database and an in-service transanal irrigation database. 4794 people were invited to participate in a single online questionnaire. Results: 183 (20%) respondents reported experience of TAI. 110 (60%) of these continue to irrigate. Many patients were still irrigating after 5 years, with variable frequency, suggesting they choose a regime to suit their illness and lifestyle. Effectiveness of TAI at 3 months was shown to correlate positively with effectiveness at 6 months, with a trend for this effectiveness to continue up to 12 months and beyond, supporting the notion that it remains effective in the longer term. Three quarters of patients treated with TAI for diarrhoea were still irrigating. Conclusion: PERSPECTIVE has demonstrated a treatment success rate of 60% with benefits continuing long term. TAI was shown to benefit patients with diarrhoea and mixed or alternating bowel symptoms. To date, there has been little assessment of the use of TAI for these symptoms which may merit future research.

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Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons (ASCRS) and Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)

et al. 2017

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OC-066 Economic and quality-of-life burden of moderate-to-severe irritable bowel syndrome with constipation (ibs-c) in the uk: the ibis-c study

Cited by 3 publications

References 0 publications

Clinical trial: predictive factors for response to gut‐directed hypnotherapy for refractory irritable bowel syndrome, a post hoc analysis

Clinical trial: predictive factors for response to gut‐directed hypnotherapy for refractory irritable bowel syndrome, a post hoc analysis

Transanal Irrigation for the Management of Functional Bowel Disorders: An Observational Study

Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons (ASCRS) and Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)

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