OC-0567: 5x4 Gy vs. 10x3 Gy for metastatic spinal cord compression: Preliminary results of the SCORE-2 trial

Rades, Dirk; Šegedin, Barbara; García, Ricardo Pardo; Metz, Michaela; Nitsche, Maria José Trevizani; Schreiber, A; Badakhshi, Harun; Hipp, Peter; Norkus, Darius; Schild, S.E.

doi:10.1016/s0167-8140(15)30673-3

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, 1x8 Gy and 5x4 Gy were combined to the short-course RT group, and 10x3 Gy, 15x2.5 Gy and 20x2 Gy were combined to the longer-course RT group. The two most frequently used fractionation schedules for MSCC, 5x4 Gy and 10x3 Gy, have been directly compared for the first time in a prospective randomized trial named SCORE-2 [ 6 ]. Preliminary results of that trial were presented at the annual ESTRO meeting last year.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it appears reasonable to compare these schedules in a randomized trial. Such a trial was begun and preliminary results presented last year at the annual ESTRO meeting [ 6 ]. Due to ethical considerations this trial was limited to patients with a poor or intermediate survival prognosis, since retrospective studies suggested that patients with more favorable survival prognoses benefit from longer-course RT such as 10x3 Gy in terms of better local control of MSCC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses

et al. 2015

View full text Add to dashboard Cite

BackgroundIt is currently not possible to get an approval of our ethics committee for a randomized trial cmparing 5x4 Gy and 10x3 Gy for MSCC that includes patients with favorable survival prognoses. Therefore, this matched-pair study following strict matching criteria was perfomed instead.MethodsIn this study, 142 receiving 5x4 Gy were retrospectively matched (1:1) to 142 patients receiving 10x3 Gy with respect to ten characteristics. These characteristics included age, gender, performance status, tumor type, involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MSCC, pre-RT ambulatory status, and time developing motor deficits.ResultsOn multivariate analysis, post-RT motor function was associated with performance status (p < 0.001), tumor type (p < 0.001), and time developing motor deficits (p < 0.001). RT was successful in 76% of patients receiving 5x4 Gy and 69% receiving 10x3 Gy (p = 0.14). Pre.RT ambulatory status showed a strong trend with respect to local control (LC) of MSCC in the multivariate analysis (p = 0.058). 1-year LC rates were 87% after 5x4 Gy and 93% after 10x3 Gy (p = 0.16). On multivariate analysis, survival (OS) was associated with performance score (p < 0.001), visceral metastases (p < 0.001), and pre-RT ambulatory status (p = 0.004). 1-year OS rates were 68% after 5x4 Gy and 73% after 10x3 Gy (p = 0.64).ConclusionsIn patients irradiated for MSCC who had favorable survival prognoses, post-RT motor function, LC and OS were not significantly different after 5x4 Gy and after 10x3 Gy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%