Abstract:IntroductionEmerging evidence in the literature has suggested fibroblast growth factor 19 (FGF19) and the farnesoid X receptor (FXR) are integral in bile acid synthesis, glucose and lipid metabolism. Reduced level of FGF19 and reduced feedback via the FXR are associated with idiopathic bile acid malabsorption (BAM) and non-alcoholic fatty liver disease (NAFLD), leading to the research and development of FXR agonists as potential treatment.In this retrospective case control study, we examined the correlation be… Show more
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