Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500

Rassat, Maïlys; Ouandji, Ingrid; Guiblin, Nicolas; Espeau, Philippe

doi:10.1016/j.ejpb.2023.114173

European Journal of Pharmaceutics and Biopharmaceutics

2024

DOI: 10.1016/j.ejpb.2023.114173

|View full text |Cite

Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500

Maïlys Rassat,

Ingrid Ouandji,

Nicolas Guiblin

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Stability of Paracetamol Amorphized by Co-Melting with Various Cellulose Derivatives

Leyk,

Plenis,

Kasprowicz

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

Co-melting paracetamol with different cellulose derivatives leads to full or partial amorphization of active substance. The aim of this study was to determine whether the amorphization of paracetamol after co-melting with cellulose derivatives is stable and whether it depends on the type of cellulose derivative added and the ratio of components. Mixtures of paracetamol with cellulose derivatives containing different proportions of components were prepared. Using differential scanning calorimetry (DSC), the samples were melted and the amorphization of paracetamol was confirmed. After 2 and 4 months, the samples were reanalyzed to determine the amorphization stability during storage and the difference in the effect of different polymers on the amorphization stability. The physical mixtures were additionally tested using Fourier transform infrared (FTIR) and Raman spectroscopic methods to confirm that no solid-phase interactions were noticed. Samples were also analyzed using ultrahigh-performance liquid chromatography (UHPLC) to assess the effect of co-melting and storage on the chemical stability of paracetamol. The results show that paracetamol amorphizes after co-melting with cellulose derivatives. The crystallization of paracetamol after co-melting depends on the polymer used and the proportions of the components. No interactions between the components and the chemical stability of paracetamol in the tested samples were confirmed.

show abstract

Stability of Paracetamol Amorphized by Co-Melting with Various Cellulose Derivatives

Leyk,

Plenis,

Kasprowicz

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500

Cited by 1 publication

References 33 publications

Stability of Paracetamol Amorphized by Co-Melting with Various Cellulose Derivatives

Stability of Paracetamol Amorphized by Co-Melting with Various Cellulose Derivatives

Contact Info

Product

Resources

About