Obtaining hydroxiapatite through biological residues for dental bone graft

García, Vanessa Sofía Bermúdez; Mujica, Karina Huaman; Castañeda-Vía, José; Landauro, C. V.; Quispe, Justiniano; Jon, Lidia Yileng Tay Chu

doi:10.20453/reh.v31i2.3971

Cited by 1 publication

(1 citation statement)

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“…HA has been widely used in biomedical applications due to its excellent biocompatibility, osteoconductivity, and similarity to the mineral component of natural bones [14]. However, the traditional process of obtaining HA involves the use of animal bones, which can lead to ethical concerns and environmental issues [15]. In addition, commercial hydroxyapatite has a very high cost of close to EUR 400/100 g. This, in addition to the fact that approximately 6000 interventions that require the use of bone filler are performed in the region of Andalusia (Southern Spain) each year, has led researchers to explore alternative sources of HA, with a particular focus on circular bioeconomy, sustainability, and clean production.…”

Section: Introductionmentioning

confidence: 99%

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

Suffo-Pino,

Cauqui-López,

Pérez-Muñoz

et al. 2023

JFB

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This study focuses on developing hydroxyapatite synthesized from a CaCO3-rich byproduct of sugar beet processing called Carbocal® using a hydrothermal reactor. The purpose of this biomaterial is to enhance the osteoinductivity of implantable surfaces and serve as a bone filler, providing a sustainable and economically more affordable alternative. This research involved compositional analysis and micro- and macrostructural physicochemical characterization, complemented with bioactivity and live/dead assays. The biphasic nature of the Carbocal®-derived sample was significant within the context of the bioactivity concept previously proposed in the literature. The bioactivity of the biomaterial was demonstrated through a viability test, where the cell growth was nearly equivalent to that of the positive control. For comparison purposes, the same tests were conducted with two additional samples: hydroxyapatite obtained from CaCO3 and commercial hydroxyapatite. The resulting product of this process is biocompatible and possesses properties similar to natural hydroxyapatite. Consequently, this biomaterial shows potential as a scaffold in tissue engineering and as an adhesive filler to promote bone regeneration within the context of the circular bioeconomy in the geographical area proposed.

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Section: Introductionmentioning

confidence: 99%