Obtaining and Investigation of the β-Cyclodextrin Inclusion Complex with Vitamin D₃ Oil Solution

Abstract

Background. The research results of fat-soluble vitamin D3 (cholecalciferol) encapsulation with β-cyclodextrin have been presented in this work. The vitamin D3 inclusion complex with β-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the β-cyclodextrin : vitamin D3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of β-cyclodextrin inclusion complex with vitamin D3 in a 2 : 1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of β-cyclodextrin with vitamin D3 was calculated using four different methods.

O colecalciferol modulado a bionanotecnologia: uma inovação na farmacoterapêutica

“…"São oligossacarídeos cíclicos que possuem uma cavidade hidrofóbica interna e uma camada externa hidrofílica. Eles são produtos de transformação bioquímica do amido" (Bakirova et al, 2020). A qual permite hospedar agentes com atividade biológica em seu interior.…”

“…Para Bakirova et al (2020): "Moléculas lipofílicas são capazes de se integrar na parte interior da ciclodextrina, formando complexos de inclusão do tipo 'hóspede-hospedeiro'. Isso proporciona mudanças significativas nas propriedades físico-químicas das substâncias ligadas; a estabilidade dos componentes 'hóspedes', sensíveis aos efeitos do oxigênio e/ou da luz, aumenta junto com a solubilidade".…”

Fortification by design: A rational approach to designing vitamin D delivery systems for foods and beverages

“…Kumar & Singhal, 2021;Morin-Crini et al, 2021;Petitjean et al, 2021;Pitha et al, 2019). Several researchers have encapsulated vitamin D within molecular complexes to improve its dispersibility, stability, and bioavailability (Abbasi et al, 2014;Bakirova et al, 2020;Delavari et al, 2015;Hasanvand et al, 2015;Santos et al, 2021;Soares et al, 2013;Taheri et al, 2021).…”

“…Detailed information about the design, fabrication, and characterization of molecular complexes is discussed elsewhere (dos Santos et al., 2017; Y. Kumar & Singhal, 2021; Morin‐Crini et al., 2021; Petitjean et al., 2021; Pitha et al., 2019). Several researchers have encapsulated vitamin D within molecular complexes to improve its dispersibility, stability, and bioavailability (Abbasi et al., 2014; Bakirova et al., 2020; Delavari et al., 2015; Hasanvand et al., 2015; Santos et al., 2021; Soares et al., 2013; Taheri et al., 2021). Researchers have shown that vitamin D forms molecular complexes with beta‐cyclodextrin, which improves its water dispersibility (Szejtli et al., 1980).…”

“…Researchers have used inclusion complexes to create vitamin D‐cyclodextrin formulations for pharmaceutical applications (Loftsson, 2006). Some researchers have shown that vitamin D can also form inclusion complexes with certain kinds of proteins and starches (Bakirova et al., 2020; Briault et al., 2011; Soares et al., 2013). For instance, vitamin D‐starch complexes were reported to be suitable for milk fortification (Hasanvand et al., 2015).…”