Obstructive sleep apnoea is associated with the development of diastolic dysfunction after myocardial infarction with preserved ejection fraction

Büchner, Stefan; Wester, Michael; Hobelsberger, Sarah; Fisser, Christoph; Debl, Kurt; Hetzenecker, Andrea; Hamer, Okka W.; Zeman, Florian; Maier, Lars S.; Arzt, Michael

doi:10.1016/j.sleep.2022.03.028

Cited by 5 publications

(5 citation statements)

References 23 publications

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“… 34 Recent evidence in humans indicates mild to moderate sleep apnea is common among patients with coronary artery diseases with increased LV wall thickness. 35 , 36 , 37 In addition, sleep restriction in the MI rat model leads to an enlarged heart size and concomitantly progresses to HF. 38 In line with these studies, we observed enlarged hearts with increased expression of HF markers, such as Nppa and Nppb , in Tg-SF mouse hearts compared to Tg-NSF mouse hearts.…”

Section: Discussionmentioning

confidence: 99%

Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

Bose,

Agrawal,

Sairam

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

Bose,

Agrawal,

Sairam

et al. 2024

iScience

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“…Patients with moderate to severe OSA and paroxysmal atrial fibrillation (AF) were more likely to have a symptomatic AF episode during sleep, 14 and OSA may impair diastolic function in patients with preserved ventricular ejection fraction post myocardial infarction. 15 Additionally, CPAP adherence was associated with lowered odds of hospital readmission at 30 days in patients over 65 years with pre-existing cardiovascular disease. 16 Conversely, Liu et al performed limited sleep studies on inpatients with STEMI undergoing primary percutaneous coronary intervention and showed that those with OSA (AHI > 15 events/h) had a higher prevalence of coronary collateral vessel development which may be beneficial, although the exact mechanism requires further investigation.…”

Section: Obstructive Sleep Apnoea Cardiovascular Effectsmentioning

confidence: 96%

“…The effect of OSA in pre‐existing cardiovascular disease received further attention in 2022. Patients with moderate to severe OSA and paroxysmal atrial fibrillation (AF) were more likely to have a symptomatic AF episode during sleep, 14 and OSA may impair diastolic function in patients with preserved ventricular ejection fraction post myocardial infarction 15 . Additionally, CPAP adherence was associated with lowered odds of hospital readmission at 30 days in patients over 65 years with pre‐existing cardiovascular disease 16 .…”

Section: Obstructive Sleep Apnoeamentioning

confidence: 99%

Contemporary Concise Review 2022: Sleep

O'Driscoll

Young

2023

Respirology

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SUMMARY OF KEY POINTS COVID‐19 and sleep The COVID‐19 pandemic is associated with an increase in insomnia and impaired sleep quality Health care workers are particularly susceptible and improved with cognitive behavioural therapy for insomnia (CBT‐I) Long COVID has significant effects on sleep OSA impacts on the severity of acute COVID‐19 illness Obstructive sleep apnoea Large trials of clinically representative patients confirm the cardiovascular benefits of CPAP treatment in OSA CPAP may improve long‐term cognitive outcomes in OSA, but further research is needed Racial disparities in OSA prevalence and mortality risk are becoming evident Periodic evaluation of OSA risk in pregnancy is important as timing may be key for intervention to prevent or treat cardiovascular risk factors Insomnia Comorbid insomnia and obstructive sleep apnoea (COMISA) can frequently co‐exist and the combined negative effects of both may be deleterious, particularly to cardiovascular health There is evidence for effectiveness with novel orexin receptor antagonists

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“…Even though only limited evidence directly elucidates the mechanisms of diastolic dysfunction in patients with SDB, it is known that many features of SDB, like intermittent hypoxia/reoxygenation, trigger pathological remodeling that might ultimately result in HFpEF [27,67]. For example, patients with an acute myocardial infarction and concomitant SDB more frequently develop diastolic dysfunction, whereas diastolic function does not change when SDB is absent [68,69].…”

Section: Pathophysiological Interactions Between Sdb and Hfmentioning

confidence: 99%

Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing

Wester,

Arzt,

Sinha

et al. 2023

Biomedicines

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Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. This is due to the various etiologies that promote HFpEF development. Indeed, cluster analyses with common HFpEF comorbidities revealed the existence of several HFpEF phenotypes. One especially frequent, yet underappreciated, comorbidity is sleep-disordered breathing (SDB), which is closely intertwined with the development and progression of the “obese HFpEF phenotype”. The following review article aims to provide an overview of the common HFpEF etiologies and phenotypes, especially in the context of SDB. As general HFpEF therapies are often not successful, patient- and phenotype-individualized therapeutic strategies are warranted. Therefore, for the “obese HFpEF phenotype”, a better understanding of the mechanistic parallels between both HFpEF and SDB is required, which may help to identify potential phenotype-individualized therapeutic strategies. Novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing further broaden the groundwork for deeper insights into pathomechanisms and precision medicine.

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Obstructive sleep apnoea is associated with the development of diastolic dysfunction after myocardial infarction with preserved ejection fraction

Cited by 5 publications

References 23 publications

Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

Contemporary Concise Review 2022: Sleep

Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing

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