Obstructive sleep apnoea: a cause of chronic cough

Birring, Surinder S.; Ing, Alvin; Chan, Kevin; Cossa, Gavina; Matos, Sérgio; Morgan, M.; Pavord, Ian D.

doi:10.1186/1745-9974-3-7

Cited by 70 publications

(55 citation statements)

References 23 publications

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“…OSA itself, with intermittent hypoxaemia, may promote profibrotic mechanisms [49]. In the general population, chronic cough is more prevalent in OSA and can be improved by treatment with continuous positive airway pressure (CPAP) [50]. A complicating factor is that obstruction of the upper airway in OSA could increase the trans-diaphragmatic pressure difference promoting GORD [51,52].…”

Section: Comorbidities Influencing Coughmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. @ERSpublications Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH

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Section: Comorbidities Influencing Coughmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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“…Unexplained chronic cough has been reported in patients who snore and who have sleep-disordered breathing (SDB) [3]. Chronic cough can be the sole manifestation of obstructive sleep apnoea (OSA) and can be effectively treated by continuous positive airway pressure (CPAP) therapy [3]. Furthermore, cough symptoms have been associated with day time somnolence in general population studies [4].…”

mentioning

confidence: 99%

“…Despite thorough investigations, the aetiology of cough is unexplained in up to 20% of patients [2]. Unexplained chronic cough has been reported in patients who snore and who have sleep-disordered breathing (SDB) [3]. Chronic cough can be the sole manifestation of obstructive sleep apnoea (OSA) and can be effectively treated by continuous positive airway pressure (CPAP) therapy [3].…”

mentioning

confidence: 99%

Chronic cough in patients with sleep-disordered breathing

Chan¹,

Ing²,

Laks³

et al. 2010

European Respiratory Journal

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Chronic cough can be the sole presenting symptom for patients with obstructive sleep apnoea. We investigated the prevalence, severity and factors associated with chronic cough in patients with sleep-disordered breathing (SDB).We invited 108 consecutive patients who had been referred for evaluation of SDB to complete a comprehensive questionnaire on respiratory and sleep health, which included the Leicester Cough Questionnaire (cough specific quality of life; LCQ), Epworth Sleepiness Scale (ESS) and the Mayo Clinic gastro-oesophageal questionnaire. Chronic cough was defined as cough for a duration of .2 months.33% of patients with SDB reported a chronic cough. Patients with a chronic cough had impaired cough related-quality of life affecting all health domains (mean¡SEM LCQ score 17.7¡0.7; normal521). Patients with SDB and chronic cough were predominantly females (61% versus 17%; p,0.001) and reported more nocturnal heartburn (28% versus 5%; p50.03) and rhinitis (44% versus 14%; p50.02) compared to those without SDB. There were no significant differences in ESS, respiratory disturbance index, body mass index, or symptoms of breathlessness, wheeze, snoring, dry mouth and choking between those with cough and those without.Chronic cough is prevalent in patients with SDB and is associated with female sex, symptoms of nocturnal heartburn and rhinitis. Further studies are required to investigate the impact of continuous positive airway pressure therapy on cough associated with SDB to explore the mechanism of this association.

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“…Resolution of cough with CPAP has been demonstrated in a case series of four patients who had objective cough recording and LCQ scores obtained pre-and post-CPAP therapy [4]. There was a significant improvement in both parameters in all patients.…”

mentioning

confidence: 95%