Obstructive Sleep Apnea Syndrome Induced by Testosterone Administration

Sandblom, Robert E.; Matsumoto, Alvin M.; Schoene, Robert B.; Lee, Kathryn A.; Giblin, Elizabeth C.; Bremner, William J.; Pierson, David J.

doi:10.1056/nejm198303033080908

Cited by 198 publications

(67 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Johnson, Anch & Remmers (1984) replicated this result with androgen administration to an asymptomatic fifty-four-year-old female. Somewhat paradoxically, in addition to the increased incidence of apnea reported in the Sandblom et al (1983), study there was an increase in the hypoxic ventilatory response. This latter result was also reported by White ,Schneider, Santeen, McDermott, Pickett, Zwillich & Weil (1985a) in a study involving testosterone administration to hypogonadal males.…”

Section: The Role Of Testosterone In Sex Differencesmentioning

confidence: 79%

Ventilation during sleep onset

Colrain

Trinder

Fraser

et al. 1987

Journal of Applied Physiology

View full text Add to dashboard Cite

There is now considerable evidence which indicates that respiratory activity is different during sleep compared with wakefulness. However, there has been little work on respiratory changes during the transitional period from wakefulness to sleep. The present study was concerned with the quantitative and temporal properties of ventilation during sleep onset. Sleep onsets were studied in five young male adults in a series of single-subject designs in which sleep onsets were replications. The results indicated that during sleep onset the loss of alpha-activity in the electroencephalogram was associated with a substantial, rapid, and highly predictable reduction in ventilation. The change in ventilation was typically due to a reduction in tidal volume and was, in part, secondary to a reduction in metabolic rate. We speculate that the nonmetabolic component may reflect the loss of waking neural drive to respiration, though the present study did not eliminate a variety of other interpretations.

show abstract

Section: The Role Of Testosterone In Sex Differencesmentioning

confidence: 79%

Ventilation during sleep onset

Colrain

Trinder

Fraser

et al. 1987

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…Among seven obese males, all except one with hypogonadism presented with sleep apnoea [133]. In males, exogenous testosterone may suppress [134] or augment [135,136] hypoxic respiratory responses and lead to periodic breathing and sleep apnoea [133,135,136]. Exogenous testosterone does not affect the upper airway dimensions in males [136].…”

Section: Androgensmentioning

confidence: 99%

Sleep-disordered breathing and hormones

Saaresranta¹,

Polo²

2003

Eur Respir J

View full text Add to dashboard Cite

Sleep-disordered breathing (SDB) is not only a problem of the upper airway but is a systemic condition with endocrine and metabolic interactions. The accumulating body of evidence shows that SDB induces changes in the serum levels or secretory patterns of several hormones. Conversely, various endocrine disorders and hormone therapies may induce, exacerbate or alleviate SDB.Much of the understanding of the interactions between hormones and sleepdisordered breathing derive from intervention studies with nasal continuous positive airway pressure therapy. Better understanding of hormones and breathing may open new perspectives in developing strategies to prevent, alleviate or cure sleep-disordered breathing and its systemic consequences. Eur Respir J 2003; 22: 161-172.

show abstract

“…Conversely, high-dose testosterone replacement in older men and the use of anabolic androgenic steroids in healthy young men are associated with a reduction in sleep efficiency and total sleep time [71,72]. A number of studies suggest that testosterone is linked to a worsening of obstructive sleep apnoea in men [71,[73][74][75]; however, blocking androgen action, via flutamide administration, does not affect sleep architecture or breathing parameters in men with sleep apnoea [76]. Interestingly, androgen deprivation therapy (ADT) for prostate cancer is highly associated with insomnia, potentially as a consequence of an increased occurrence of hot flushes and night sweats [77,78].…”

Section: (C) Sex Steroids Influence Sleepmentioning

confidence: 99%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

397

300

View full text Add to dashboard Cite

One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Men and women sleep differently. While much is known about the mechanisms that drive sleep, the reason for these sex differences in sleep behaviour is unknown and understudied. Historically, women and female animals are underrepresented in studies of sleep and its disorders. Nevertheless, there is a growing recognition of sex disparities in sleep and rhythm disorders. Women typically report poorer quality and more disrupted sleep across various stages of life. Findings from clinical and basic research studies strongly implicate a role for sex steroids in sleep modulation. Understanding how neuroendocrine mediators and sex differences influence sleep is central to advancing our understanding of sleep-related disorders. The investigation into sex differences and sex steroid modulation of sleep is in its infancy. Identifying the mechanisms underlying sex and gender differences in sleep will provide valuable insights leading to tailored therapeutics that benefit each sex. The goal of this review is to discuss our current understanding of how biological sex and sex steroids influence sleep behaviour from both the clinical and pre-clinical perspective.

show abstract

Obstructive Sleep Apnea Syndrome Induced by Testosterone Administration

Cited by 198 publications

References 15 publications

Ventilation during sleep onset

Ventilation during sleep onset

Sleep-disordered breathing and hormones

Sex differences in sleep: impact of biological sex and sex steroids

Contact Info

Product

Resources

About