Obstructive sleep apnea syndrome and asthma: the role of continuous positive airway pressure treatment

Alkhalil, Michel; Schulman, Edward S.; Getsy, Joanne

doi:10.1016/s1081-1206(10)60309-2

Cited by 61 publications

(48 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the exact prevalence of OSA in asthmatic patients is not known but the incidence of OSA has been reported to be approximately 2.5 times greater in asthma patients than those without asthma [5,6].…”

Section: Introductionmentioning

confidence: 99%

Long-term CPAP treatment improves asthma control in patients with asthma and obstructive sleep apnoea

et al. 2016

View full text Add to dashboard Cite

Purpose Both asthma and obstructive sleep apnoea cause sleep disturbance, daytime sleepiness and diminished quality of life. Continuous positive airway pressure (CPAP) is efficient in reducing symptoms related to sleep apnoea. Here we report the impact of long-term use of CPAP on asthma symptoms. Methods A survey questionnaire was distributed to all of our obstructive sleep apnoea patients with CPAP therapy in 2013. We used the Finnish version of the Asthma Control Test™ (ACT) and a visual analogue scale (0 = no symptoms, 100 = severe asthma symptoms). Asthma was defined as self-reported physician-diagnosed disease and a special reimbursement for asthma medication by the Social Insurance Institution. Results We sent 2577 questionnaires and received 1586 answers (61 %). One hundred ninety-seven patients were asthmatics with a prevalence of asthma among CPAP users of 13 %. We studied 152 patients (58 females) whose CPAP therapy was initiated after starting asthma medication. Their mean (SD) age was 62 (10) years, duration of CPAP 5.7 (4.7) years and their CPAP daily use was 6.3 (2.4) h. Self-reported asthma severity decreased significantly from 48.3 (29.6) to 33.1 (27.4) (p < 0.001), and ACT score increased significantly from 15.35 (5.3) to 19.8 (4.6) (p < 0.001) without a significant change in the body mass index (BMI). The percentage of patients using rescue medication daily reduced from 36 to 8 % with CPAP (P < 0.001). Conclusions We noticed a significant decrease in asthma symptoms with long-term use of CPAP in patients with both asthma and obstructive sleep apnoea.

show abstract

Section: Introductionmentioning

confidence: 99%

Long-term CPAP treatment improves asthma control in patients with asthma and obstructive sleep apnoea

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Therapy with continuous positive airway pressure has been shown to improve asthma control and quality of life [85,86], although no change in pulmonary function or airway hyperresponsiveness has been observed [86]. Therefore, sleep-disordered symptoms should be routinely assessed and polysomnography should be performed if necessary.…”

Section: Phenotype-specific Treatmentmentioning

confidence: 99%

Severe refractory asthma: an update

Wener

Bel

2013

European Respiratory Review

View full text Add to dashboard Cite

Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved in a substantial proportion despite currently available treatment possibilities. This subgroup has been defined as ''severe refractory'' asthma. Over the past years considerable progress has been made regarding a more exact definition of severe refractory asthma. A systematic approach to evaluate the asthma patient has been postulated. Further detailed classification into distinct phenotypes is ongoing to target the right treatment to the right patient. And, new therapeutic targeted treatment options are currently in development to provide possible new targets to improve disease state, symptoms and quality of life. This review will provide an update on the latest advancements with regard to all these domains. @ERSpublications Phenotyping the severe asthma patient is essential to ensure the right treatment is given to the right patient

show abstract

“…Para os portadores de overlap syndrome, está indicado o uso de CPAP ou BiPAP durante o sono na presença de hipoventilação associada e consequente hipercapnia. Em um estudo recente, (20) (12) O uso bem indicado e criterioso de CPAP nesses casos mostra evidências de vários efeitos benéficos interagindo no binômio asma-SAOS, como os efeitos positivos sobre a inflamação brônquica e sistêmica, a diminuição da hiper-reatividade brônquica, a melhora na arquitetura do sono, a redução do peso corpóreo, a supressão da produção de lecitina pelo tecido adiposo, a melhora na função cardíaca e a redução importante do refluxo gastroesofágico.…”

Section: Asma Brônquicaunclassified

Sono e doenças pulmonares crônicas: pneumopatias intersticiais difusas, asma brônquica e DPOC

Cabral

Mueller

2010

J. bras. pneumol.

View full text Add to dashboard Cite

ResumoAs doenças pulmonares crônicas podem ser agravadas por inúmeros fatores e comorbidades, inclusive pelos distúrbios respiratórios do sono. Embora alterações na qualidade de vida de pacientes com doenças pulmonares crônicas sejam normalmente determinadas a partir de variáveis diurnas, as alterações fisiopatológicas no sono pioram a qualidade de sono e interferem na história natural dessas doenças. Alterações da arquitetura do sono parecem ser um mecanismo comum entre essas doenças. Durante o sono, as vias respiratórias inferiores estão mais interligadas às vias respiratórias superiores, quando as alterações de resistências das vias aéreas superiores durante o sono somam-se às graves alterações resistivas de vias aéreas inferiores devido a asma e DPOC. Além disso, surgem complexas interações mecânicas e ventilatórias. O reconhecimento dessas interações possibilita uma melhor avaliação das exacerbações e da evolução dessas doenças.Descritores: Sono; Asma; Doença pulmonar obstrutiva crônica; Doenças pulmonares intersticiais. AbstractChronic lung diseases can be aggravated by various factors and comorbidities, including sleep-disordered breathing. Although changes in the quality of life of patients with chronic lung disease are usually related to daytime variables, the physiological changes in sleep impair the quality of sleep and interfere with the natural history of the disease. Alterations in sleep architecture appear to be a common mechanism in these diseases. During sleep, the upper and lower airways are more interconnected: changes in upper airway resistance during sleep are added to the severe resistive alterations in the lower airways due to asthma and COPD. In addition, there are complex mechanical and ventilatory interactions. The recognition of these interactions allows better assessment of the exacerbations and the progression of chronic lung diseases.Keywords: Sleep; Asthma; Pulmonary disease, chronic obstructive; Lung diseases; interstitial. IntroduçãoA fisiologia respiratória durante o sono é consideravelmente diferente quando comparada à vigília. Em indivíduos saudáveis, a passagem da vigília ao sono está associada à queda de 5-10% da ventilação minuto, com queda adicional de até 40% durante o sono REM. Vários são os fatores responsáveis pela queda da ventilação durante o sono em indivíduos saudáveis: redução da taxa metabólica basal, aumento da resistência da via aérea superior, perda do estímulo da vigília para respirar e fatores relacionados ao sono REM: diminuição do estímulo central muscular respiratório e hipotonia da musculatura acessória e intercostal da respiração.(1)Essas alterações fisiológicas que ocorrem normalmente durante o sono não promovem efeitos deletérios em indivíduos saudáveis. Entretanto, em portadores de doenças pulmonares, especialmente em portadores de DPOC, podem ocorrer acentuada hipoxemia e hipercapnia. (2) Este capítulo pretende descrever as alterações fisiopatológicas que ocorrem durante o sono nas principais doenças pulmonares: pneumopatias intersticiais difusas, a...

show abstract

Obstructive sleep apnea syndrome and asthma: the role of continuous positive airway pressure treatment

Cited by 61 publications

References 73 publications

Long-term CPAP treatment improves asthma control in patients with asthma and obstructive sleep apnoea

Long-term CPAP treatment improves asthma control in patients with asthma and obstructive sleep apnoea

Severe refractory asthma: an update

Sono e doenças pulmonares crônicas: pneumopatias intersticiais difusas, asma brônquica e DPOC

Contact Info

Product

Resources

About