Obstructive sleep apnea may increase the risk of Alzheimer's disease

Przybylska-Kuć, Sylwia; Zakrzewski, Maciej; Dybała, Andrzej; Kiciński, Paweł; Dzida, Grzegorz; Myśliński, Wojciech; Prystupa, Andrzej; Mosiewicz-Madejska, Barbara; Mosiewicz, Jerzy

doi:10.1371/journal.pone.0221255

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…Finally, transdermal E2 improves sleep quality, reduces sleep latency, and decreases awakenings in postmenopausal women (47-65 years), especially those with insomnia ( 92 , 93 ). Given that sleep apnea/insomnia are risk factors for Alzheimer’s disease (AD) ( 94 , 95 ), attenuating risk at midlife can have important implications for women’s health. Thus, greater research attention paid to the potential role of E2/P in preventing sleep disorders at midlife is needed.…”

Section: Contributions Of Menopause-associated Hormone Changes To Slementioning

confidence: 99%

Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan

Brown

Gervais

2020

Endocrinology

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Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological processes, including sleep. Beginning at puberty, girls report more sleep complaints than boys, which is maintained throughout the reproductive life stage. Sleep problems are exacerbated during the menopausal transition, evidenced by greater risk for sleep disorders. There is emerging evidence that menopause-associated hormone loss contributes to this elevated risk, but age is also an important factor. The extent to which menopause-associated sleep disturbance persists into postmenopause above and beyond the effects of age remains unknown. Untreated sleep disturbances have important implications for cognitive health, as they are emerging as risk factors for dementia. Given that sleep loss impairs memory, an important knowledge gap concerns the role played by menopause-associated hormone loss in exacerbating sleep disturbance and ultimately, cognitive function in aging women. In this review, we take a translational approach to illustrate the contribution of ovarian hormones in maintaining the sleep-wake cycle in younger and middle-aged females, with evidence implicating 17β-estradiol in supporting the memory-promoting effects of sleep. Sleep physiology is briefly reviewed before turning to behavioural and neural evidence from young females linking 17β-estradiol to sleep-wake cycle maintenance. Implications of menopause-associated 17β-estradiol loss is also reviewed before discussing how ovarian hormones may support the memory-promoting effects of sleep, and why menopause may exacerbate pathological aging via effects on sleep. While still in its infancy, this research area offers a new sex-based perspective on aging research, with a focus on a modifiable risk factor for pathological aging.

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Section: Contributions Of Menopause-associated Hormone Changes To Slementioning

confidence: 99%

Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan

Brown

Gervais

2020

Endocrinology

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“…Intermittent hypoxia and sleep fragmentation in OSA patients may significantly affect the brain structure and cause problems with β-amyloid metabolism. Individuals with severe OSA compared to individuals with or without moderate OSA have significantly higher β-Amyloid isoform 40 (Aβ 40 ) plasma concentrations (Przybylska-Kuć et al, 2019). These plasma concentrations could be connected to hypoxia severity and, consequently, may also indicate an increased risk for the development of AD.…”

Section: Resultsmentioning

confidence: 99%

Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review

Kuo

Hsiao²,

Lo³

et al. 2021

Front. Aging Neurosci.

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Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.

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“…Individuals with vascular dementia, AD and other types of dementia are often diagnosed with sleeping pattern problems. Many studies, which findings are given in Table 6 , have proposed an association between sleep problems, especially, for obstructive sleep apnea patients and a higher risk of dementia [ 56 , 121 , 122 , 123 ]. Some researchers believe that obstructive sleep apnea may even start the AD neuropathological process [ 124 ].…”

Section: Other Established (Non-)modifiable Risk Factors and Possimentioning

confidence: 99%

Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer’s Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia

Kuo

Stachiv

Nikolai

2020

IJERPH

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The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease; depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied. It has been proposed that to understand mechanisms of dementia and Alzheimer’s disease pathogeneses require their multifactorial nature represented by these multiple factors to be considered. In this review, we first summarize the recent literature findings on roles of the late life depression and the other known (non-)modifiable risk and possibly protective factors in development of dementia and Alzheimer’s disease. Then, we provide evidences supporting hypotheses that (i) depressive syndromes in late life may indicate the prodromal stage of dementia (Alzheimer’s disease) and, (ii) the interplay among the multiple (non-)modifiable risk and protective factors should be considered to gain a better understanding of dementia and Alzheimer’s disease pathogeneses. We also discuss the evidences of recently established interventions considered to prevent or delay the prodromes of dementia and provide the prospective future directions in prevention and treatment of dementia and Alzheimer’s disease using both the single-domain and multidomain interventions.

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Obstructive sleep apnea may increase the risk of Alzheimer's disease

Cited by 22 publications

References 20 publications

Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan

Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan

Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review

Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer’s Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia

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