Obstructive Sleep Apnea Induced by a Parapharyngeal Cystic Hygroma in an Infant

Kahn, André; Blum, Davi Francisco Casa; Hoffman, A; Hamoir, Marc; Moulin, D.; Spehl, M; Montauk, Lance

doi:10.1093/sleep/8.4.363

Cited by 18 publications

(8 citation statements)

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“…The majority of included patients had their neoplasms treated surgically, with 57 patients (72.2%) treated with surgery alone 9–12,14–61 . Two patients (2.5%) were treated with both surgery and radiotherapy, 13,62 and one patient (1.3%) treated with each of surgery and chemotherapy 63 and surgery and chemoradiotherapy 64 .…”

Section: Resultsmentioning

confidence: 99%

Scoping review of head and neck neoplasms presenting with obstructive sleep apnoea: the importance of flexible nasendoscopy

Moore

Cardemil

Hayward

et al. 2020

ANZ Journal of Surgery

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Background Obstructive sleep apnoea (OSA) can be caused by neoplasms involving the upper aerodigestive tract. Currently, many of these patients have this diagnosis missed, as most adults diagnosed with OSA do not undergo adequate head and neck examination including flexible nasendoscopy. We performed a review of the literature to shed light on this phenomenon and outline the pathologies and issues surrounding this sub‐population of patients diagnosed with OSA. Methods A scoping review of the literature was conducted on head and neck neoplasms presenting with OSA. Data were extracted on demographics, clinical presentation, histopathology, treatment and patient outcomes. Results Sixty‐seven articles were included, describing 79 patients. Mean age was 45.8 years, and 77.2% were male. Symptoms of OSA were present for an average of 29.2 months before a diagnosis of causative neoplasm was made. Forty‐two different benign and malignant histopathological entities were reported. At diagnosis, the causative pathology of 100% of patients was visible on head and neck examination including flexible nasendoscopy, while only 53.2% were visible on trans‐oral examination. One‐third of patients had commenced inappropriate treatment for OSA, including three who had undergone sleep surgical procedures. The majority of patients were treated with surgery alone (72.2%). Conclusion Although rare, neoplasms of the upper aerodigestive tract should be considered as a cause of OSA, especially in patients experiencing other symptoms in addition to the typical symptoms of OSA. They should particularly be considered in patients with comparatively lower body mass index or those with worsening OSA without an apparent cause identified.

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Section: Resultsmentioning

confidence: 99%

Scoping review of head and neck neoplasms presenting with obstructive sleep apnoea: the importance of flexible nasendoscopy

Moore

Cardemil

Hayward

et al. 2020

ANZ Journal of Surgery

View full text Add to dashboard Cite

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“…20 Given the prevalence of vascular malformations in these anatomic sites, an increased risk of sleep-disordered breathing might be anticipated; however, very little literature exists regarding the association between pediatric head and neck vascular malformations and OSA. 14,15,[21][22][23] In 2009, Bloom et al published the results from a survey of American Society of Pediatric Otolaryngology members regarding management of lymphatic malformations and macroglossia. 24 Airway obstruction and/or obstructive sleep apnea was the most commonly reported indication for tongue-reduction procedures in this population.…”

Section: Discussionmentioning

confidence: 99%

Sleep‐disordered breathing in pediatric head and neck vascular malformations

et al. 2017

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“…There have been case reports demonstrating OSA in patients with other lymphatic disorders, such as malformation or neoplasia. [24][25][26][27] However, there are no clinical standards for the evaluation of cervical lymph nodes in the management of OSA.…”

Section: Osa and Cervical Lymph Node Hypertrophymentioning

confidence: 99%

Deep cervical lymph node hypertrophy: A new paradigm in the understanding of pediatric obstructive sleep apnea

et al. 2013

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Objective To determine if adenotonsillar hypertrophy is an isolated factor in pediatric obstructive sleep apnea (OSA) or if it is part of larger spectrum of cervical lymphoid hypertrophy. Study Design Prospective case control study. Methods A total of 70 screened patients (mean age 7.47 years) underwent polysomnography to confirm OSA and then underwent MRI of the upper airway. 76 matched controls (mean age 8.00 years) who already had an MRI underwent polysomnography. Volumetric analysis of lymphoid tissue volumes was carried out. Chi-square analysis and Student’s t-test were used to compare demographic data and lymph node volumes between cohorts. Fisher’s Exact test and Chi-square analysis were used to compare sleep data. Results Patients and controls demonstrated no significant difference in mean age (7.47 vs 8.00 yrs), weight (44.87 vs 38.71 kg), height (124.68 vs 127.65 cm), or body-mass index (23.63 vs 20.87 kg/m2). OSA patients demonstrated poorer sleep measures than controls(p<0.05)in all polysomnography categories (sleep efficiency, apnea index, apnea-hypopnea index, baseline SpO2, SpO2 nadir, baseline ETCO2, peak ETCO2, and arousal awakening index). Children with OSA had higher lymphoid tissue volumes than controls in the retropharyngeal region (3316 vs 2403 mm3, p<0.001) upper jugular region (22202 vs 16819 mm3, p<0.005), and adenotonsillar region (18994 vs 12675 mm3, p<0.0001). Conclusions Children with OSA have larger volumes of deep cervical lymph nodes and adenotonsillar tissue than controls. This finding suggests a new paradigm in the understanding of pediatric OSA and has ramifications for future research and clinical care.

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Obstructive Sleep Apnea Induced by a Parapharyngeal Cystic Hygroma in an Infant

Cited by 18 publications

References 0 publications

Scoping review of head and neck neoplasms presenting with obstructive sleep apnoea: the importance of flexible nasendoscopy

Scoping review of head and neck neoplasms presenting with obstructive sleep apnoea: the importance of flexible nasendoscopy

Sleep‐disordered breathing in pediatric head and neck vascular malformations

Deep cervical lymph node hypertrophy: A new paradigm in the understanding of pediatric obstructive sleep apnea

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