Obstructive sleep apnea in patients with rheumatoid arthritis: Correlation with disease activity and pulmonary function tests

Fouda, Neven; Dayem, Aya Abdel

doi:10.1016/j.ejr.2014.04.002

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…While the discomforts associated with RA can cause sleep disturbances, poor sleep has also been shown to increase joint pain independent of anxiety and depression [14, 20]. For example, patients with OSA have greater disease activity as represented by DAS28 and higher levels of c-reactive protein [44]. In an experimental model of partial night sleep deprivation comparing patients with RA and control subjects, patients with RA reported worsening pain and an increase in the number of affected joints after sleep loss.…”

Section: Non-inflammatory Pain Generators In Rheumatoid Arthritismentioning

confidence: 99%

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Types of pain and their psychosocial impact in women with rheumatoid arthritis

Chancay

Guendsechadze

Blanco

2019

womens midlife health

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Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease predominantly affecting middle-aged women. Very commonly, pain is a manifestation of active disease and because untreated RA can result in joint deformities, the current evaluation of pain has largely focused on inflammation. In addition, treatment has centered on the premise of reducing disease activity with the hopes of halting worsening damage, preventing future deformities, and ultimately providing pain relief for the patient. Yet research shows that all patients with RA, but women in particular, often suffer from increased mechanical pain and fibromyalgia, as well as anxiety, depression, sleep disturbances, sexual dysfunction, and disability, which add to the burden of the illness. Determining and addressing alternative pain triggers as well as understanding the psychosocial burden of RA is key in treating patients, especially in those who may not improve with traditional pharmacotherapy.

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Section: Non-inflammatory Pain Generators In Rheumatoid Arthritismentioning

confidence: 99%

“…At times, patients are not even aware that they have poor sleep. In a study looking at thirty female patients with RA, fourteen met the criteria for diagnosis of OSA despite six of them reporting not having any sleep problems [44]. Patients with RA and fatigue and/or poor sleep, benefit from an evaluation for restless leg syndrome and OSA.…”

Section: Treatmentmentioning

confidence: 99%

Types of pain and their psychosocial impact in women with rheumatoid arthritis

Chancay

Guendsechadze

Blanco

2019

womens midlife health

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“…For instance, a meta-analysis conducted by Thakur et al noted a 29.8% prevalence of SRBD among RA patients [ 29 ]. Importantly, there has been just one other prospective, albeit cross-sectional, study that has utilized empirical sleep assessment (polysomnography) to ascertain the prevalence of SRBD in RA, finding sleep apnea in 47.7% o the participants [ 39 ]. Literature on SRBD prevalence in PsA remains even more limited, with cross-sectional, self-reported sleep assessments being the primary method for examining the link between SRBD and PsA [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing sleep-related breathing disorders among newly diagnosed rheumatoid and psoriatic arthritis patients: a cross-sectional study

Petzinna,

Winter,

Skowasch

et al. 2024

Rheumatol Int

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Objectives This cross-sectional study aimed to determine the prevalence and risk factors for sleep-related breathing disorders (SRBD) in newly diagnosed, untreated rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients, and to develop a screening algorithm for early detection. Methods We evaluated newly diagnosed RA or PsA patients using the Epworth Sleepiness Scale (ESS) questionnaire, cardiorespiratory polygraphy (RPG), and clinical and laboratory assessments. Sleep apnea syndrome (SAS) was diagnosed based on pathological RPG findings excessive daytime sleepiness, defined as ESS score above 10. Results The study included 39 patients (22 RA, 17 PsA) and 23 controls. In RPG, SRBD was identified in 38.5% of arthritis patients compared to 39.1% of controls (p = 1.00), with male gender (p = .004) and age (p < .001) identified as risk factors. Excessive daytime sleepiness was noted in 36.4% of RA patients, 17.6% of PsA patients, and 21.7% of controls. Of the 24 patients diagnosed with SRBD, 41.6% met the criteria for SAS. SAS prevalence was 31.8% among RA patients, 0% in PsA patients, and 13% in controls. A significant association was observed between excessive daytime sleepiness and SRBD (p = .036). Conclusion Our findings reveal a high prevalence of SRBD in newly diagnosed, untreated RA and PsA patients in ESS and RPG, with excessive daytime sleepiness being a reliable predictor of SRBD. Patients with RA exhibited a higher predisposition to SAS. We therefore suggest incorporating ESS and RPG as screening tools in RA or PsA for early detection and management of SRBD.

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“…Out of the eight included and unique studies, three were conducted in the USA, [20][21][22] and the rest were conducted in Japan, 23 Saudi Arabia, 24 Taiwan, 25 Egypt, 26 and Brazil. 27 These eight studies yielded a total of 585 patients with OSA among the total sample size of 37 285 patients with RA.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence of obstructive sleep apnea among patients with rheumatoid arthritis and its association with age and body mass index: A systematic review and meta‐analysis

et al. 2021

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In a number of rheumatic diseases akin to rheumatoid arthritis (RA)-osteoarthritis, systemic lupus erythematosus, Sjögren syndrome, fibromyalgia, juvenile idiopathic arthritis, systemic sclerosis, spondyloarthritis, and Behçet syndrome-sleep abnormalities comprising reduced sleep, sleep fragmentation, and insomnia have been recognized. 1 Sleep apnea is an under-recognized comorbidity among rheumatology patients and its presence may adversely affect the evaluation of rheumatic disease activity and treatment responses. 2

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Obstructive sleep apnea in patients with rheumatoid arthritis: Correlation with disease activity and pulmonary function tests

Cited by 9 publications

References 35 publications

Types of pain and their psychosocial impact in women with rheumatoid arthritis

Types of pain and their psychosocial impact in women with rheumatoid arthritis

Assessing sleep-related breathing disorders among newly diagnosed rheumatoid and psoriatic arthritis patients: a cross-sectional study

Prevalence of obstructive sleep apnea among patients with rheumatoid arthritis and its association with age and body mass index: A systematic review and meta‐analysis

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