Obstructive Sleep Apnea Comorbid with Late-Onset Kleine–Levin Syndrome: A Rare Condition

Divya, M. P.; Kumar, Akash; Gupta, Shivam; Tale, Sudheer; Saini, Lokesh Kumar; Gupta, Ravi

doi:10.1007/s41782-020-00096-3

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Similarly bifrontotemporal hypoperfusion has been reported in COVID-19 cases which can possibly explain KLS symptoms as well [ 15 ]. Obstructive sleep apnea (OSA) can coexist with KLS, so a sleep study should be done in high-risk patients as treatment of OSA can result in quick resolution of symptoms [ 16 ]. Management strategies vary based on symptomology.…”

Section: Discussionmentioning

confidence: 99%

Possible role of COVID-19 in the relapse of Klein-Levin Syndrome

Nasrullah¹,

Javed²,

Ashraf³

et al. 2021

Respiratory Medicine Case Reports

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Klein-Levin Syndrome (KLS) is an extremely rare neurological disorder which can manifest as recurring spells of sleepiness, cognitive disturbances and behavioral changes. We present a novel case of KLS relapse in the setting of Coronavirus disease-19 (COVID-19). A 36-year-old male who had a known history of KLS since adolescence was admitted with sleepiness and behavioral disturbances. Brain imaging and autoimmune encephalitis work was unremarkable. The patient was diagnosed with a relapse of KLS secondary to COVID-19 based on symptomology and lack of any other precipitating factor. The patient required 8 days of hospitalization and was treated with benzodiazepines due to a history of robust response to lorazepam during a prior episode. The patient progressively improved and was discharged home on lorazepam taper. We report that similar to other neurotropic viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be the culprit in instigating KLS relapse.

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Section: Discussionmentioning

confidence: 99%

Possible role of COVID-19 in the relapse of Klein-Levin Syndrome

Nasrullah¹,

Javed²,

Ashraf³

et al. 2021

Respiratory Medicine Case Reports

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A Review on Sleep Disorder Analysis and Applications Based on Artificial Intelligence

Mathew

Vivekanandan

2021

Advances in Medical Technologies and Clinical Practice

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The recent developments in multi-modular sensor technology for analyzing physiological and psychological activities have brought a breakthrough in the biomedical engineering thereby aiding the real-time monitoring of various vital signals. The monitoring of circadian rhythms and EEG signals keeps a proper observation on sleep and analyzes various sleep disorders. The sleep patterns related to disease and wellness applications can be analyzed with the help of multi-sensor-generated data. Several challenges such as performance evaluation, data storage, processing and integration, modeling, and interpretation as well as curation are to be overcome in this field for expansion of this technology in the future. The digitalization of sleep is an interdisciplinary field of research incorporating neuroscience, bioengineering, epidemiology, clinical medicine, computer science, and electrical engineering. This chapter discusses various sleep disorders, AI, analysis, and applications available. Finally, the challenges and future scope are also discussed followed by the conclusion.

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Atypical Kleine Levin Syndrome: Atypical or “Something Else”

2024

J Psychol Neurosci

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Objective: To describe in some detail published cases who were diagnosed as atypical Kleine-Levin syndrome (KLS), and discuss the validity and usefulness of this diagnostic term. Methods: The English written literature was reviewed using the search terms Atypical KLS, KLS mimic, KLS like and KLS variant. Only reports which provided complete clinical features were reviewed. The present diagnostic criteria of KLS were applied in each case and the reasons why each case was considered as atypical were outlined in a table form. The cases were grouped according to the primary etiologies which could explain the symptoms into infectious, autoimmune, cerebrovascular, head trauma, brain tumor and genetic metabolic disorders. Cases in whom we could not establish a definite diagnosis were coined “atypical “and a few which could not be assigned to a specific group were coined “miscellaneous”. Results: Fifty seven reports describing 60 “atypical“ cases were found. Out of those, 14 suffered from a variety of medical conditions which could explain the symptomology while in 19 cases a definite diagnosis could not reached. Five cases were coined as “miscellaneous” since we could not assign them to a specific group. Conclusion: The eponym “atypical” KLS, refers to patients in whom a variety of medical disorders were associated with sleep-wake disorder, however, it seems appropriate that in such cases the diagnosis should express the primary cause of the symptoms rather than suggesting that those cases are a variant of KLS.

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Obstructive Sleep Apnea Comorbid with Late-Onset Kleine–Levin Syndrome: A Rare Condition

Cited by 3 publications

References 19 publications

Possible role of COVID-19 in the relapse of Klein-Levin Syndrome

Possible role of COVID-19 in the relapse of Klein-Levin Syndrome

A Review on Sleep Disorder Analysis and Applications Based on Artificial Intelligence

Atypical Kleine Levin Syndrome: Atypical or “Something Else”

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