2021
DOI: 10.3390/ijms222212536
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Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening

Abstract: Obstructive sleep apnea (OSA) is chronic disorder which is characterized by recurrent pauses of breathing during sleep which leads to hypoxia and its two main pathological sequelae: oxidative stress and chronic inflammation. Both are also associated with cellular senescence. As OSA patients present with higher prevalence of age-related disorders, such as atrial hypertension or diabetes mellitus type 2, a relationship between OSA and accelerated aging is observable. Furthermore, it has been established that the… Show more

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Cited by 25 publications
(18 citation statements)
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References 85 publications
(108 reference statements)
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“…The cause of HIF-1 α overexpression in patients suffering from the aforementioned diseases is not clear. One of the postulated factors is oxidative stress caused by an imbalance between the increased production of reactive oxygen species and a relative shortage of antioxidant defense and increased HIF-1 α expression in the protective response to oxidative stress [ 110 , 111 , 112 , 113 ], which is similar to the cellular senescence process in OSA patients [ 114 ]. Furthermore, increased HIF-1 levels in the brain may improve creatinine metabolism and correlate with a better treatment response to antidepressants [ 115 ].…”
Section: Clinical Implications Of Circadian Rhythm Gene Disruption In Osa Patientsmentioning
confidence: 99%
“…The cause of HIF-1 α overexpression in patients suffering from the aforementioned diseases is not clear. One of the postulated factors is oxidative stress caused by an imbalance between the increased production of reactive oxygen species and a relative shortage of antioxidant defense and increased HIF-1 α expression in the protective response to oxidative stress [ 110 , 111 , 112 , 113 ], which is similar to the cellular senescence process in OSA patients [ 114 ]. Furthermore, increased HIF-1 levels in the brain may improve creatinine metabolism and correlate with a better treatment response to antidepressants [ 115 ].…”
Section: Clinical Implications Of Circadian Rhythm Gene Disruption In Osa Patientsmentioning
confidence: 99%
“…Its prevalence is increasing worldwide [3,4]. Metabolic disorders are in particular closely associated with OSA syndrome (OSAS) which is a chronic disorder characterized by intermittent hypoxia during sleep with re-oxygenation injury [5,6]. In fact, more than two thirds of people with OSA is at least overweight and weight loss helps reduce OSA severity or attenuate other symptoms (reviewed in [7]).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, OSA is currently -regarded as an additional factor contributing to the pathogenesis of obesityrelated comorbidities [8]. Multiple comorbid conditions such as metabolic complications (e.g., obesity, cardiovascular risk factors, ischemic heart disease and atrial fibrillation, impaired lipid levels, insulin resistance or type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD)), insomnia, depression (up to 35% [9]) or accelerated aging are particularly prevalent in individuals with OSA [3,5,[10][11][12][13]. Among OSA patients there are those with extremely high prescription of antidepressants, anxiolytics, hypnotics and sedatives [3].…”
Section: Introductionmentioning
confidence: 99%
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