Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan

Chen, Yuli; Weng, Shih‐Feng; Shen, Yeh-You; Chou, Chien-Wen; Yang, Chwen-Yi; Wang, Jhi-Joung; Tien, Kai‐Jen

doi:10.1210/jc.2014-1718

Cited by 58 publications

(71 citation statements)

References 34 publications

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“…[1][2][3][4] Extensive evidence has shown that sleep disturbance is an independent risk factor of increased overall mortality, 5 increased psychiatric and medical morbidity, 6,7 decreased physical and cognitive function, 8,9 and decreased health-related quality of life (HRQOL) 10,11 among older adults.…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Sleep Quality, Duration, and Health-Related Quality of Life in Older Chinese: Evidence From a Rural Town in Suzhou, China

Pan

Cong

Zhou³

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: To determine the associations of self-reported sleep quality and duration with health-related quality of life (HRQOL) in older Chinese. Methods: We analyzed community-based cross-sectional data of 5,539 individuals aged 60 years and older in the Weitang Geriatric Disease Study. Information of sleep quality and duration were self-reported through participants' responses to predefined questions; HRQOL data were collected by using the European Quality of Life-5 Dimensions (EQ-5D). We estimated the associations of sleep quality and duration with the EQ-5D index and visual analog scale (VAS) scores using linear regression models. The associations between sleep quality and duration and EQ-5D-detected health problems were modeled using logistic regression. Results: In multiple linear models adjusting sociodemographic factors, health conditions, and lifestyle habits, both EQ-5D index and VAS scores declined with deterioration of sleep quality. The coefficients for poor and intermediate sleep quality were −0.053 (95% confidence interval [CI]:−0.065, −0.042) and −0.022 (95% CI: −0.030, −0.013), respectively, in relation to EQ-5D index score. They were −5.2 (95% CI: −6.7, −2.4) and − 3.8 (95% CI: −4.9, −2.7) in modeling the EQ-5D VAS score. HRQOL declined as sleep duration decreased below 7.01 hours or exceeded 8.01 hours, though most of the associations did not reach statistical significance. In multiple logistic models, poor sleep quality was associated with problems of mobility, pain/discomfort, and anxiety/ depression; short sleep duration was associated with mobility problems. Conclusions: Poor sleep quality and extreme sleep durations appeared to be negatively associated with HRQOL in older Chinese adults. Keywords: China, EQ-5D, health-related quality of life, older adults, sleep duration, sleep quality Citation: Pan CW, Cong X, Zhou HJ, Li J, Sun HP, Xu Y, Wang P. Self-reported sleep quality, duration, and health-related quality of life in older Chinese: evidence from a rural town in Suzhou, China.

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Section: Introductionmentioning

confidence: 99%

Self-Reported Sleep Quality, Duration, and Health-Related Quality of Life in Older Chinese: Evidence From a Rural Town in Suzhou, China

Pan

Cong

Zhou³

et al. 2017

Journal of Clinical Sleep Medicine

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“…Sleep apnea is common in the general population 1 and is associated with severe health problems, such as cognitive dysfunction, 2 diabetes, 3 osteoporosis, 4 hypertension, 5 cardiovascular diseases, and mortality. 6 Sleep apnea also shares several symptoms with depression, such as fatigue, disturbed sleep, irritability, depressed mood, and poor concentration.…”

Section: Introductionmentioning

confidence: 99%

Sleep apnea severity and depressive symptoms in a population-based study

et al. 2015

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“…Several papers report a vicious circle between vitamin D deficiency, OSAS, and glucose metabolism: patients with severe OSAS had lower vitamin D levels [68], the risk of osteoporosis in the OSAS cohort was 2.74 times than patients without sleep disorders [69], and recently some authors reported that vitamin D deficiency (closely linked to osteoporosis and diabetes) may play a role and worsen OSAS's adverse outcomes and comorbidities, especially those regarding glucose metabolism [70,71].…”

Section: Osas and Bone Metabolismmentioning

confidence: 99%

Sleep apnea syndrome in endocrine clinics

Ceccato

Bernkopf²,

Scaroni

2015

J Endocrinol Invest

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Obstructive sleep apnea syndrome (OSAS) is a chronic condition with a high prevalence (up to 7 % of the general population) characterized by frequent episodes of upper airway collapse while sleeping. Left untreated, OSAS can cause severe complications, including systemic hypertension, cardiovascular disease, stroke, and abnormal glucose metabolism. This review aims to summarize the close links between OSAS, endocrinology, and metabolism. In patients with metabolic syndrome, OSAS is an independent risk factor for the onset of type 2 diabetes and a worsening glycemic control. The accumulation of adipose tissue in the neck and limited chest wall dynamics, hypoxia, and local micro-inflammation link visceral obesity closely with OSAS. There is now an abundance of convincing data indicating that promoting lifestyle changes, improving sleep hygiene, and adjusting diet can ameliorate both metabolic syndrome and OSAS, especially in obese patients. The incidence of OSAS in acromegaly is high, though GH treatments seem to be unrelated to the onset of apnea in GH-deficient individuals. Prospective studies have suggested an association between hypertension and OSAS because intermittent nocturnal hypoxia prompts an increase in sympathetic tone, endothelial dysfunction, and vascular inflammation: aldosterone excess may have a pathophysiological role, and some authors have reported that treating OSAS leads to a modest, but significant, reduction in blood pressure.

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Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan

Abstract: People diagnosed with OSA are at increased risk for subsequent osteoporosis.

Cited by 58 publications

References 34 publications

Self-Reported Sleep Quality, Duration, and Health-Related Quality of Life in Older Chinese: Evidence From a Rural Town in Suzhou, China

Self-Reported Sleep Quality, Duration, and Health-Related Quality of Life in Older Chinese: Evidence From a Rural Town in Suzhou, China

Sleep apnea severity and depressive symptoms in a population-based study

Sleep apnea syndrome in endocrine clinics

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