Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro.

Plusa, S. M.; Webster, Nigel R.; Primrose, John

doi:10.1136/gut.38.5.784

Cited by 23 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another study confirmed that phagocytic function of neutrophils was impaired in OJ rats but no difference in neutrophil chemotactic response and superoxide release was observed [11]. Impaired neutrophil chemotaxis and adhesion in OJ was also found by others [12,13]. These findings suggest neutrophil inactivity in OJ.…”

Section: Introductionsupporting

confidence: 74%

Reversibility of leukocyte dysfunction in rats with obstructive jaundice

Li¹,

Sung²,

Chung³

2004

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 74%

Reversibility of leukocyte dysfunction in rats with obstructive jaundice

Li¹,

Sung²,

Chung³

2004

Journal of Surgical Research

View full text Add to dashboard Cite

“…Perioperative complications in patients with obstructive jaundice included infections, endotoxemia, renal failure, stress ulceration, disseminated intravascular coagulation, and wound dehiscence [14,15] . Numerous reports suggested that in obstructive jaundice there was not only impairment of hepatocellular function but also depression of Kupffer cell activity and ultimately hepatic structural damage, leading to the development of portal hypertension [16,17] .…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats

Wang

Dou²,

Li³

et al. 2003

WJG

View full text Add to dashboard Cite

AIM:To investigate the hepatocellular apoptosis after hepatectomy in obstructive jaundice and biliary decompression rats. METHODS:After bile duct ligation for 7 days, rats were randomly divided into OB group in which the rats underwent 70 % hepatectomy, OB-CD group in which the rats underwent hepatectomy accompanied by choledochoduodenostomy, CDHx group in which the rats underwent choledochoduodenostomy and then received 70 % hepatectomy on the fifth day after biliary decompression. The control group (Hx group) only underwent hepatectomy. RESULTS:The level of total serum bilirubin and serum enzymes was significantly lower in CD-Hx group than in OB-CD and OB groups on day 1, 3 and 5 after hepatectomy. The apoptotic index was significantly lower in CD-Hx group than in OB-CD and OB groups on day 3 and 5. The oligonucleosomal DNA fragments and Caspase-3 activity were also lower in CD-Hx group than in OB-CD and OB groups 3 days after hepatectomy, without differences between CD-Hx and Hx groups.CONCLUSION: Hepatocellular apoptosis plays vital roles in jaundice rats, and biliary decompression is more effective in treatment of patients with severe jaundice before operation.Wang DS, Dou KF, Li KZ, Gao ZQ, Song ZS, Liu ZC. Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats.

show abstract

“…However, about one third of patients with BA remain jaundiced even after prompt intervention, and in another one third of patients, jaundice reappears after recurrent episodes of ascending cholangitis (2). Increased susceptibility to various infectious pathogens has been noted in patients with cholestatic jaundice and cholestatic animal model (3)(4)(5)(6). A previous study showed that the incidence of sepsis in jaundiced patients ranged from 25% to 72%, and the mortality rate was around 20% to 30% (7).…”

mentioning

confidence: 99%

Impaired T-Lymphocyte Proliferation Function in Biliary Atresia Patients With Chronic Cholestatic Jaundice After a Kasai Operation

Chiang

Chen

et al. 2006

Pediatr Res

View full text Add to dashboard Cite

ABSTRACT:To investigate the association between chronic cholestatic jaundice, systemic immunity, and various infectious complications in patients with biliary atresia (BA), we performed a survey of the systemic immune function in 30 children with BA. Patients were divided into a jaundice group (total serum bilirubin Ն2 mg/dL for Ͼ6 mo) and control group (total serum bilirubin Ͻ2 mg/dL for Ͼ6 mo) with comparable age. Patients were tested for serum immunoglobulin and complement levels, mitogen response, interleukin (IL)-4, IL-5, and interferon-gamma production after phytohemagglutinin (PHA) stimulation, blood cell and lymphocyte subpopulation counts, phagocytic function, and leukocyte adhesion complex. They were then followed prospectively for 6 mo, and severe infectious complications requiring hospitalization were recorded. Compared with jaundice-free patients, T-lymphocyte proliferation function, determined by PHA mitogen test was significantly lower (p ϭ 0.02) in BA patients with chronic cholestatic jaundice after a Kasai operation. During the study period, patients with chronic cholestatic jaundice had a higher risk of severe infectious complications than their jaundice-free counterparts (risk ratio ϭ 5.87; p ϭ 0.001). In conclusion, BA patients with chronic cholestatic jaundice are associated with impairment of T-lymphocyte proliferation and increased incidence of severe infectious complications.

show abstract

Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro.

Cited by 23 publications

References 27 publications

Reversibility of leukocyte dysfunction in rats with obstructive jaundice

Reversibility of leukocyte dysfunction in rats with obstructive jaundice

Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats

Impaired T-Lymphocyte Proliferation Function in Biliary Atresia Patients With Chronic Cholestatic Jaundice After a Kasai Operation

Contact Info

Product

Resources

About