Obstructive events in children with Prader-Willi syndrome occur predominantly during REM sleep

Prader-Willi Syndrome-Improvement of Cognitive Function through Noninvasive Ventilation in Children

“…Physical factors include the association of infantile hypotonia with onset during the intrauterine life (reduced fetal movements), hypogonadism, craniofacial dysmorphism, scoliosis, obesity and short stature [11][12][13]. Patients have characteristic physiological traits (muscular hypotonia, metabolic imbalance, sleep related respiratory problems, excessive daytime sleepiness), associated with psychological traits with various degrees of impairment (tantrums, hyperphagia, obsessive-compulsive behavior, irritability, low frustration threshold, intellectual impairment) [11][12][13][14][15]. Phenotypic changes are the consequence of genetic damage in PWS.…”