Obstruction of the inferior vena cava in the hepatic portion and hepatocellular carcinoma.

Nakamura, Shozo; Takezawa, Yoshiaki

doi:10.1620/tjem.138.119

Cited by 20 publications

(10 citation statements)

References 4 publications

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“…The reported incidence of LC among patients with IVCO varied from 71% to 100% and the incidence of HCC from 6.4% to 43.7% 17–19,21 , 22 . Follow up of patients with IVCO showed that they develop HCC 7–25 years after the onset of the disease 34,35 . Although the exact etiopathogenesis of this clinical entity is not fully understood, the high incidence of HCC among patients with IVCO may be due to a congestive state over a period of several years and recurrent episodes of liver damage 14,36 .…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19]21,22 Follow up of patients with IVCO showed that they develop HCC 7-25 years after the onset of the disease. 34,35 Although the exact etiopathogenesis of this clinical entity is not fully understood, the high incidence of HCC among patients with IVCO may be due to a congestive state over a period of several years and recurrent episodes of liver damage. 14,36 Two important clinical features of IVCO are its chronic nature and recurrent acute exacerbation.…”

Section: Discussionmentioning

confidence: 99%

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High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal

Shrestha¹,

Shrestha²,

Tsuda

et al. 2007

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal

Shrestha¹,

Shrestha²,

Tsuda

et al. 2007

J of Gastro and Hepatol

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“…Obstruction of the hepatic portion of the inferior vena cava (IVCO) is a form of BCS commonly seen in Asia [1][2][3][4][5][6][7][8][9] and Africa [10][11][12] but rarely reported from western countries [13,14]. It is a primary disease of the hepatic portion of the IVC caused by bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

“…The reported incidence (Table 1) of LC in the disease had varied from 71% to 100% [2,3,5] and that of HCC from 4.6% to 47% [2,3,5,7,9,11,12,18,19]. As HVD occurred in areas endemic for hepatitis B virus (HBV) infection [11,20], some considered HBV infection as the likely cause of LC/HCC in this disease [21].…”

Section: Introductionmentioning

confidence: 99%

“…Findings of equally high incidence of HCC in IVCO S. M. Shrestha (&) Liver Foundation Nepal, Sitapaela Height, P.O. Box 3439, Kathmandu, Nepal e-mail: liver@mail.com.np in Japan and South Africa, the two countries with four times difference in HBsAg carrier rates, led others to believe that IVCO was etiologically related to HCC [5,11,19]. Here, we report a longitudinal study of HVD patients in Nepal, a country endemic for HVD [9] and low HBsAg carrier rate of 0.9% [22], and discuss the pathogenesis of LC/HCC in HVD.…”

Section: Introductionmentioning

confidence: 99%

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Liver cirrhosis and hepatocellular carcinoma in hepatic vena cava disease, a liver disease caused by obstruction of inferior vena cava

Shrestha¹

2009

Hepatol Int

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Purpose Hepatic vena cava disease (HVD), a form of Budd-Chiari syndrome, is caused by the obstruction of hepatic portion of the inferior vena cava. It is a chronic disease characterized by the development of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). As HVD occurred in areas with high incidence of hepatitis B virus (HBV) infection and some patients tested HBsAg positive, it was thought to be the cause of LC and HCC. To assess the pathogenesis of LC or HCC in HVD, a long-term follow-up study was done. Method Fifty-six patients with HVD diagnosed by ultrasound (US) and confirmed by cavography in 31 and liver biopsy in 34 were followed up for an average of 14.8 ± 9 years. The occurrence of LC was diagnosed by US and/or liver biopsy and that of HCC by US, elevated level of a-fetoprotein, and liver biopsy or fine-needle aspiration cytology, or computed tomographic scan. Other risk factors for LC/HCC such as alcohol use and HBV and hepatitis C virus (HCV) infections were assayed. Results Forty-four (78.5%) and 6 (10.7%) patients developed cirrhosis and HCC, respectively. LC/HCC occurred more frequently among those who had severe or frequent acute exacerbations (P = 0.017), but it was not related to alcohol use or HBV and HCV infections. Conclusion HVD is independent risk factors for LC and HCC. Severe and/or recurrent loss of hepatocytes caused by hepatic venous outflow obstruction and/or thrombotic obstruction of small radicals of hepatic and portal veins that occurred during acute exacerbations was considered important in the pathogenesis of LC and HCC in HVD.

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Budd-Chiari Syndrome/Hepatic Venous Outflow Tract Obstruction: East vs West

Valla

2016

Portal Hypertension VI

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Obstruction of the inferior vena cava in the hepatic portion and hepatocellular carcinoma.

Cited by 20 publications

References 4 publications

High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal

High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal

Liver cirrhosis and hepatocellular carcinoma in hepatic vena cava disease, a liver disease caused by obstruction of inferior vena cava

Budd-Chiari Syndrome/Hepatic Venous Outflow Tract Obstruction: East vs West

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