Obstetrical and Neonatal Outcomes of Pregnancies following Gastric Bypass Surgery: A Retrospective Cohort Study in a French Referral Centre

Santulli, Piétro; Mandelbrot, Laurent; Facchiano, Enrico; Dussaux, Chloé; Ceccaldi, Pierre-François; Ledoux, Séverine; Msika, Simon

doi:10.1007/s11695-010-0260-6

Cited by 72 publications

(68 citation statements)

References 67 publications

(65 reference statements)

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“…Keywords searched were: "bariatric surgery and reproduction". Forty articles were identified, but fifteen articles were reviews [67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] , sixteen articles were on pregnancy outcomes after bariatric surgery [83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98] , three were commentaries or author replies [99][100][101] , two investigated contraceptive use post-bariatric surgery 102,103 , one was a cross-sectional assessment of reproductive health in women undergoing bariatric surgery 104 , one was a case report of empty follicle syndrome in a woman post-bariatric surgery undergoing IVF 105 , and one article was a case series of IVF in women who had previously undergone bariatric surgery 106 . In these last two articles, special considerations were outlined for IVF in women with previous bariatric surgery 106 .…”

Section: Weight Loss Through Bariatric Surgerymentioning

confidence: 99%

Obesity and reproductive function

Klenov¹,

Jungheim²

2014

Current Opinion in Obstetrics &Amp; Gynecology

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SYNOPSISObesity is associated with multiple adverse reproductive outcomes, but the mechanisms involved are largely unknown. Public health scientists studying obesity and its effects on health outcomes have referred to obesity as a "complex system", defined as a system of heterogeneous parts interacting in nonlinear ways to influence the behavior of the parts as a whole 1,22 . By this definition, human reproduction is also a complex system which may explain some of the difficulty in identifying the mechanisms linking obesity and adverse reproductive function. Despite the difficulties, research on obesity and reproduction is important as there is an epidemic of obesity among reproductive age women with associated consequences for future generations. In this review we discuss the adverse reproductive outcomes associated with obesity and data from translational studies of the mechanisms involved. We conclude with a brief discussion of public health policy as it relates to the treatment of infertility in obese women. Keywords fertility; obesity; reproduction; public health MEASURING OBESITY AND REPRODUCTIVE RISKDisentangling the individual components of obesity associated with poor health outcomes is difficult. Body mass index (BMI) or overall body size adjusted for height, is obviously, the most accessible measure of obesity as the tools for measuring BMI are readily available. On the other hand, adiposity (regional or total body fat), adipokine production, and lifestyle components may also contribute individually or together to overall obesity-related health risk. The bulk of the work relating obesity to health risks has focused on chronic diseases, however, we are learning more about components of obesity that relate to reproductive risk.

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Section: Weight Loss Through Bariatric Surgerymentioning

confidence: 99%

Obesity and reproductive function

Klenov¹,

Jungheim²

2014

Current Opinion in Obstetrics &Amp; Gynecology

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“…Indeed, we found a statistically significant association between prior bariatric surgery and delivery of an infant that was SGA (regardless of maternal obesity status), even after controlling for maternal anemia status. Santulli and colleagues [19] investigated neonatal outcomes following one type of bariatric procedure [Roux en Y Gastric Bypass (RYGBP)] using a retrospective cohort design and also concluded that bariatric surgery was associated with reduced birth weight.…”

Section: Discussionmentioning

confidence: 99%

Impact of prior bariatric surgery on maternal and fetal outcomes among obese and non-obese mothers

Belogolovkin

Salihu

Weldeselasse

et al. 2011

Arch Gynecol Obstet

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“…While there were 4 papers showing a decrease in the rates of GD [13,16,20,22] , the majority did not show a difference. It has been theorized that there is a reduction in the rates of GD after bariatric surgery due to absorption or metabolic changes [24] . However, our data did not show a difference in the rates of GD between the two groups.…”

Section: Gdmentioning

confidence: 99%

“…Five studies were included in our review of IUGR rates in respect to bariatric surgery [14,16,[22][23][24] . Individually, they found either no difference or an increased rate of IUGR among the bariatric surgical patient as compared to their control.…”

Section: Iugrmentioning

confidence: 99%

“…Both malabsorption and nutritional deficiencies are more often associated with gastric bypass procedures rather than the banding procedure. A sub analysis to compare the two procedures was not able to be performed as two of the studies only included the Roux-en-Y bypass [23,24] while the other three did not specify the surgical procedure performed. Further studies would need to be performed to determine the IUGR rates in bypass versus banding patients.…”

Section: Iugrmentioning

confidence: 99%

See 1 more Smart Citation

Maternal and fetal delivery outcomes in pregnancies following bariatric surgery: a meta-analysis of the literature

Young¹,

Drew²,

Ibikunle³

et al. 2018

MIS

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Aim: The objective of this study is to evaluate maternal and fetal outcomes following pregnancies after bariatric surgery as compared to the general population affected by obesity. Methods:A systematic review was conducted through MEDLINE, Cochrane, and EMBASE to identify relevant studies from 2007 to 2016 with comparative data on the maternal and fetal delivery outcomes following bariatric surgery as compared to the population affected by obesity. The primary outcome analyzed was the rate of cesarean deliveries.Other outcomes included intrauterine growth restriction, small for gestational age, large for gestational age, macrosomia pregnancy-induced hypertension, gestational diabetes, assisted vaginal delivery, and preterm delivery. Statistical analysis was done using fixed-effects meta-analysis to compare the mean value of the two groups (Comprehensive Meta-Analysis Version 3.3.070 software; Biostat Inc., Englewood, NJ). Results:Out of 549 studies, 13 were quantitatively assessed and included for meta-analysis. The need for caesarean sections in post-bariatric women was found to be significantly lower when compared to women affected by obesity [odds ratio (OR) 0.623, P < 0.001). There were also significant reduction in the incidence of LGA (OR 0.491, P < 0.001), macrosomia (OR 0.251, P < 0.001), and assisted vaginal delivery (OR 0.807, P < 0.001) in the post bariatric group of women. There was an increase in the incidence of PIH (OR 1.113, P < 0.001), SGA (OR 2.305, P < 0.001) and IUGR (OR 2.099, P < 0.001). The incidence of preterm delivery (OR 0.982, P > 0.05) and gestational diabetes (OR 1.046, P > 0.05) were similar in both groups. Conclusion:Patients affected by obesity considering conceiving in the near future should consider bariatric surgery prior to conception to lower their risk of potentially adverse delivery outcomes.

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Obstetrical and Neonatal Outcomes of Pregnancies following Gastric Bypass Surgery: A Retrospective Cohort Study in a French Referral Centre

Abstract: RYGBP surgery was associated with reduced birthweight, suggesting a possible role of nutritional growth restriction in pregnancy.

Cited by 72 publications

References 67 publications

Obesity and reproductive function

Obesity and reproductive function

Impact of prior bariatric surgery on maternal and fetal outcomes among obese and non-obese mothers

Maternal and fetal delivery outcomes in pregnancies following bariatric surgery: a meta-analysis of the literature

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