Obstetrical and neonatal outcomes of triplet births – spontaneous versus assisted reproductive technology conception

Abstract

Rates of preterm birth and related complications remain high in triplet gestation. However, obstetrical and neonatal outcomes were similar for triplets conceived spontaneously versus via ART.

The Relationship of Assisted Reproductive Technology on Perinatal Outcomes in Triplet Gestations

“…Similar to our study, there were no differences in maternal or neonatal complications studied between both groups. 4 However, in both Fennessy et al 4 and Morency et al, 7 no confounders were adjusted; our study accounted for this to assess any true differences in outcomes from triplets conceived by ART. Of note, triplets conceived by ART were more likely to have trichorionic triamniotic (TCTA) placentation; TCTA triplets had lower mortality rates than other triplet combinations.…”

“…Similar to our study, neonatal complications were studied as a secondary outcome and no significant differences were found between both groups. 7 Differences in GA at birth can likely be attributed to ART patients being more associated with a higher socioeconomic status and education level leading to earlier and better access to prenatal care and a healthier lifestyle. 21 In our multivariate logistic regression, ethnicity and GA at delivery were the factors that made the largest difference to the ORs.…”

“…4 With up to 95% of all triplet pregnancies being preterm deliveries, they are subsequently associated with short-and long-term complications. [5][6][7] In addition, with high order pregnancies, maternal morbidity is increased with higher rates of gestational diabetes, pre-eclampsia, placental abruption, and postpartum complications. 8 Prior studies have shown varying results when comparing neonatal and maternal outcomes for twin pregnancies conceived via ART versus spontaneously.…”

“…[9][10][11][12] However, only limited data exists for perinatal outcomes when comparing mode of conception for triplet pregnancies. 4,7,13 The purpose of this study is to evaluate neonatal outcomes in triplets conceived spontaneously versus via ART utilizing a large dataset.…”

Excessive Neutrophil Activity in Gestational Diabetes Mellitus: Could It Contribute to the Development of Preeclampsia?

“…The degree of GCT discordance was greatest in pregnancies with triplet fetuses, whilst it was still significantly altered in those with twins ( 54 ). An independent examination of pregnancies with triplet fetuses indicated that 10% were affected by GDM ( 55 ).…”