Obstetric implications of fetal inherited thrombophilia in thrombophilic women

Bellussi, Federica; Contro, E.; Legnani, Cristina; Galletti, Silvia; Cosentino, A; Rizzo, Nicola; Ghi, T.

doi:10.1016/j.preghy.2013.11.001

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…In comparison, in the study of Deveer et al [12] , the authors reported no significant differences between PE patients and controls regarding the prevalence of FVL gene mutation. Likewise, in the study of Bellussi et al [13] suggested that women with inherited thrombophilia carrying a thrombophilic fetus are not at increased risk of adverse pregnancy outcomes. In addition, the study of Rodger et al [14] on 7343 women, including 6.9% with FVL, showed that carriers of FVL are not at increased risk of pregnancy complications.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Alsheikh

ElSadek

Gebreel

2020

International Journal of Medical Arts

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Background: Factor V [Leiden] mutation, also known as activated protein-C resistance, is the most common of the inherited thrombophilias. Aim of the work:The present study aimed to ass the prevalence of factor V Leiden mutation in a group of Egyptian pregnant women and its relation to maternal and neonatal outcomes. Patients and methods:The present prospective study included 130 preeclamptic women with a singleton pregnancy in the 3rd trimester. Blood samples were obtained for DNA analysis to assay factor V Leiden mutation. Transabdominal obstetric ultrasound examination was performed to confirm the fetal number, viability, presentation, estimated fetal weight, position & grade of the placenta, amount of liquor, biophysical profile, and gestational age. This was achieved through the measurements of the biparietal diameter, head circumference, abdominal circumference, and femur length. Flow velocity waveforms were obtained from each uterine artery.Results: Factor V Leiden [FVL] mutation was identified in 20 patients [15.4 %]. Comparison between women with FVL and women without revealed a significantly higher frequency of intrauterine growth restriction [IUGR], intrauterine fetal death [IUFD], small for gestational age [SGA], preterm labor, and intensive care unit [ICU] admission among women with FVL mutation. They also have a significantly higher frequency of abnormal Doppler findings, abruptio placenta, and placental infarction. Conclusion:The present study suggested that maternal and neonatal complications in PE patients may be related to FVL, abnormal uterine artery Doppler findings, and placental infarction.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Alsheikh

ElSadek

Gebreel

2020

International Journal of Medical Arts

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“…There were selected twenty-seven articles demonstrating the association between hereditary thrombophilia and preeclampsia to emphasize the involved of mutations of clotting factors in the development of this complication. From selected publications, an increased risk of preeclampsia and severe preeclampsia has been reported in pregnant women with heterozygous V Leiden gene mutation, heterozygous prothrombin gene mutation and homozygous MTHFR gene mutation (7). A total of 2264 pregnant women where included in all 27 studies, without risk factors.…”

Section: Hereditary Thrombophilia and Preeclampsiamentioning

confidence: 99%

Maternal and Fetal Complications Occurring in Hereditary Thrombophilia

Nacea¹,

Cernea²,

Enăchescu³

et al. 2017

Ro J Pediatr.

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Objective. To identify qualitative and quantitative changes involving coagulation factors engaged in maternal and fetal complications, to determine the level of correlation between them, and to highlight the involvement of hereditary thrombophilia among pregnant women. Material and method. The article is based on 92 publications from 1995 to 2017, including a total of 49,127 thrombophilic patients, of whom 1272 were controls, with inclusion criteria as preeclampsia, intrauterine growth retardation, or early or late pregnancy loss Results. 31 studies based on preeclampsia-demonstrate the involvement of G1691A factor V Leiden gene mutation, G20210A Prothrombin gene mutation and/or C677T and A1298C MTHFR gene mutation as the main factors in the development of this complication. 10 studies focuses on the intrauterine growth restriction place G20210A Factor V Leiden gene mutation, G20210A Prothrombin gene mutation, C677T and A1298C MTHFR gene mutation, protein C and protein S deficiency as the main factors involved. Another 32 studies cite the involvement of factor V Leiden mutation, Prothrombin mutation and MTHFR mutation in the development of early or late pregnancy losses. Conclusion. Based on 92 rigorously selected publications, we were able to demonstrate the relationship between medium/increased risk thrombophilia and pregnancy outcome, especially due to the presence of factor V Leiden gene mutation, Prothrombin gene mutation but also MTHFR gene mutation homozygous status.

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Obstetric implications of fetal inherited thrombophilia in thrombophilic women

Cited by 2 publications

References 47 publications

Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Maternal and Fetal Complications Occurring in Hereditary Thrombophilia

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