Obstetric factors related to bacteremia in the newborn infant

Tyler, Carl W.; Albers, William H.

doi:10.1016/0002-9378(66)90035-4

Cited by 26 publications

(9 citation statements)

References 15 publications

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“…[1112131415161718] In 1963, Pryles et al .,[11] reported effect of chorioamniotic infection on newborns by using UCBC in 150 patients. In 1966, Albers and Tyler[12] studied umbilical cultures for diagnosis of neonatal sepsis. In 1981, Polin et al .,[13] reported use of UCBC for diagnosis of neonatal sepsis by collecting 200 UCBC.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size of above-mentioned studies ranged from 30 to 319. [11121314151617] Studies by Herson et al ., and Fos et al ., closely resemble our study, which focused on perinatal risk factors of neonatal sepsis. Herson et al ., had a sample size of 81 and Fos et al ., had an effective sample size of 30 UCBCs.…”

Section: Discussionmentioning

confidence: 99%

“…Albers and Tyler had 9% (13 out of 319), and Polin et al ., had 3% (6 out of 200) positive UCBC. [1213] These studies were screening studies without any focus on risk factors. In a study of Pryles et al .,[11] umbilical cord culture positive rate was 47% in high-risk newborns.…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies on umbilical cord blood culture (UCBC) for diagnosis of neonatal sepsis, which suggest umbilical cord blood can be collected for blood culture safely and without contamination. [51112131415] We did a study for evaluating UCBC for diagnosis of early neonatal sepsis in high-risk new borns.…”

Section: Introductionmentioning

confidence: 99%

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Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors

Kalathia¹,

Shingala²,

Parmar³

et al. 2013

J Clin Neonatol

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Context:Blood culture is gold standard for diagnosis of neonatal sepsis. Low sensitivity of blood culture is usually due to small volume of blood sample, intrapartum antibiotics, and antibiotics given to newborn before sampling.Aim:We evaluated use of Umbilical cord blood culture (UCBC) in diagnosis of neonatal sepsis as compared to peripheral venous blood culture.Settings and Design:This study was done in tertiary care teaching hospital during May-June 2012. A total of 45 newborns with presence of two or more risk factors of sepsis were included.Subjects and Methods:Blood sample from placental end of umbilical cord was collected and cultured. Primary outcome was diagnosis of neonatal sepsis by use of umbilical cord blood sample as compared with venous blood sample. Secondary outcome was to compare organisms identified by UCBC and venous blood culture.Statistical Analysis:Sensitivity, specificity, positive and negative predictive values of UCBC were calculated.Results:A total of 24.44% (11 out of 45) high-risk newborns had positive UCBC. A total of 17.8% (8 out of 45) newborns had positive blood culture report. Organisms grown in UCBC were Pseudomonas (45%, 5 out of 11), Acinetobacter (27.27%, 3 out of 11), Escherichia coli (18.18%, 2 out of 11), and Klebsiella (9%, 1 out of 11).Conclusion:UCBC is a good method for diagnosis of neonatal sepsis among high-risk newborns as compared to venous blood culture with a sensitivity of 80% and specificity of 91.43%. Organisms grown are comparable to blood culture samples.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors

Kalathia¹,

Shingala²,

Parmar³

et al. 2013

J Clin Neonatol

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“…Neonatal sepsis is a serious condition of ten followed by complications [1], Its inci dence has increased during the last decade [2,3], Certain predisposing factors related to pregnancy, delivery, as well as neonatal dis eases have been identified [4][5][6], Premature delivery, delay after rupture of membranes and absence of specific humoral antibody against the pathogen [3,9,10] are complica tions which often greatly increase the risk for infection of the amniotic fluid [7,8], The risk of becoming infected is greater if gesta tion is less than 34 weeks [4,5]. However, there are data showing that the occurrence of infected neonates at full-term pregnancies is increasing [3][4][5], Little is known about other predisposing risk factors and what influence obstetrical routine at a full-term pregnancy may have.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Sepsis Neonatorum following a Full-Term Pregnancy

Ahldén¹,

Andersch²,

Stigsson³

et al. 1988

Gynecol Obstet Invest

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The aim of the present study was to identify obstetrical factors predicting sepsis neonatorum following a full-term pregnancy. In 1982 26 infants out of 2,977 full-term pregnancies had septicemia. For comparison 42 women of corresponding age were randomly selected. A stepwise regression analysis was performed in order to evaluate the association between seven different variables and sepsis neonatorum. We found that prolonged rupture of the membranes (p < 0.003) and primary amniotomy (p < 0.02) were the most important factors predicting sepsis neonatorum (r² = 0.22). Factors such as cervical ripening, vaginal examinations, intrauterine monitoring devices, prolonged labor and prolonged pregnancy did not add to the predicted power of the analysis.

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