Obstetric Complications and Polygenic Risk Score: Which Role in Predicting a Severe Short-Term Outcome in Psychosis?

Tosato, Sarah; Bonetto, Chiara; Vassos, Evangelos; Lasalvia, Antonio; Santi, Katia De; Gelmetti, Margherita; Cristofalo, Doriana; Richards, Alexander; Ruggeri, Mirella

doi:10.3390/genes12121895

Cited by 4 publications

(1 citation statement)

References 62 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Notwithstanding, the prenatal and perinatal period are considered windows of particularly heightened vulnerability to environmental insults due to the brain maturational events ongoing at this stage. 3 Obstetric complications (OCs) have thus been identified among the most robust environmental risk factors 1,4,5 and adverse events during pregnancy, labour, delivery and the early neonatal period have been associated with the onset of psychosis in later life. 6 A recent meta-analysis sought to summarise the evidence added in the last 20 years since the literature on the role of OCs in psychosis risk was last meta-analysed.…”

Section: Introductionmentioning

confidence: 99%

Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis

Valli

Segura

Verdolini³

et al. 2023

Acta Psychiatr Scand

View full text Add to dashboard Cite

Background Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosis proneness. We examined the role of distinct types of OCs in terms of psychosis risk and tested whether they interact differently with genetic vulnerability, whilst accounting for other known environmental risk factors. Study Design 405 participants (219 first episode psychosis patients and 186 healthy volunteers) underwent a comprehensive assessment of OCs, measured using the Lewis‐Murray scale and divided into complications of pregnancy, abnormalities of foetal growth and development, and complications of delivery. Participants were compared in terms of history of OCs, polygenic risk score for schizophrenia (PRS‐SZ) and interactions between these. Results Both complications of pregnancy and abnormalities of foetal growth were significantly associated with case–control status (p = 0.02 and 0.03, respectively), whereas complications of delivery were not. PRS‐SZ showed a significant association with psychosis (p = 0.04), but there were no significant interactions between genetic risk for schizophrenia and OCs, either when these were considered globally or separated based on their timeframe. Conclusions We observed no significant interaction between genetic and obstetric vulnerability, yet distinct types of OCs may have a different impact on psychosis risk, based on their nature and timeframe. Examining their differential role might clarify their relative contributions to this risk.

show abstract

Section: Introductionmentioning

confidence: 99%

Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis

Valli

Segura

Verdolini³

et al. 2023

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

Social exclusion as a major outcome domain of psychotic disorders: early predictors, and associations with non-recovery and clinical staging 21 years after a first episode of psychosis

Peralta,

de Jalón,

Moreno-Izco

et al. 2024

Soc Psychiatry Psychiatr Epidemiol

View full text Add to dashboard Cite

Relapse in schizophrenia: The role of factors other than non‐adherence to treatment

Smit,

Luckhoff,

Phahladira

et al. 2024

Early Intervention Psych

View full text Add to dashboard Cite

AimRelapse rates are very high in schizophrenia. However, little is known about the predictors of the time to relapse other than treatment non‐adherence. We investigated possible risk factors for the time to relapse in patients with first‐episode schizophrenia (n = 107) who received assured treatment by way of long‐acting injectable antipsychotic over 24 months and who underwent regular clinical, cognitive, and metabolic assessments.MethodsUsing Cox regression analyses we assessed selected premorbid and baseline potential predictors of time to relapse. Relapse was defined using operationally defined relapse criteria.ResultsIn the primary analysis only neurological soft signs total score retained significance, with higher scores predicting shorter time to relapse (HR = 1.05, 95% CI = 1.01–1.10, p = .029). In a more detailed secondary analysis poorer social relationships predicted shorter time to relapse (HR = 0.85, 95% CI = 0.76–0.95, p = .003).ConclusionOur predominantly negative findings suggest that many of the previously implicated risk factors for the time to relapse are mediated by non‐adherence rather than having a direct effect on relapse‐proneness. Neurological soft signs, and perhaps quality of life in social relationships appear to play a role and merit further investigation.

show abstract

Obstetric Complications and Polygenic Risk Score: Which Role in Predicting a Severe Short-Term Outcome in Psychosis?

Cited by 4 publications

References 62 publications

Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis

Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis

Social exclusion as a major outcome domain of psychotic disorders: early predictors, and associations with non-recovery and clinical staging 21 years after a first episode of psychosis

Relapse in schizophrenia: The role of factors other than non‐adherence to treatment

Contact Info

Product

Resources

About