Obstetric Cholestasis: Investigation of a suspected high incidence in the West of Ireland

Corcoran, Aoife; Langan, H

doi:10.1016/j.ejogrb.2021.12.009

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…25 Although there are comprehensive studies on the clinical symptoms, signs, and treatments of ICP in the literature, 17,[26][27][28][29] systematic reviews and meta-analyses regarding the incidence and maternal, fetal, and neonatal outcomes of ICP are limited. 4,22,30 Additionally, there is a need for up-to-date evidence for health care professionals to provide quality care services by knowing the maternal, fetal, and neonatal adverse outcomes of ICP. For these reasons, this systematic review and meta-analysis was conducted, and the results from this systematic review and meta-analysis contribute to identifying the maternal, fetal, and neonatal outcomes of ICP and guide health care professionals providing care to pregnant individuals with ICP.…”

Section: Introductionmentioning

confidence: 99%

“…1 Among liver diseases occurring during pregnancy, ICP ranks second after viral hepatitis and is recognized as the most common liver disorder specific to pregnancy. [2][3][4] Additionally, the incidence of ICP varies depending on the ethnic composition of the population and di-agnostic criteria. In the literature, the occurrence of ICP in pregnancy ranges from 0.2% to 6.1%, showing significant variations based on ethnicity and geographical location.…”

Section: Introductionmentioning

confidence: 99%

“…It is clinically characterized by itching in the absence of a rash in the pregnant woman, along with abnormal liver function tests showing an elevated serum bile acid level (≥10 μmol/L) 1 . Among liver diseases occurring during pregnancy, ICP ranks second after viral hepatitis and is recognized as the most common liver disorder specific to pregnancy 2–4 . Additionally, the incidence of ICP varies depending on the ethnic composition of the population and diagnostic criteria.…”

Section: Introductionmentioning

confidence: 99%

“…The aim of a systematic review and meta‐analysis, prepared by bringing together research results appraised by quality assessment tools and conducting a critical analysis, is to obtain the best evidence about the subject 25 . Although there are comprehensive studies on the clinical symptoms, signs, and treatments of ICP in the literature, 17,26–29 systematic reviews and meta‐analyses regarding the incidence and maternal, fetal, and neonatal outcomes of ICP are limited 4,22,30 . Additionally, there is a need for up‐to‐date evidence for health care professionals to provide quality care services by knowing the maternal, fetal, and neonatal adverse outcomes of ICP.…”

Section: Introductionmentioning

confidence: 99%

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The Incidence of Intrahepatic Cholestasis of Pregnancy and its Maternal, Fetal, and Neonatal Adverse Outcomes: A Systematic Review and Meta‐Analysis

Odabaş,

Sökmen,

Dünder

et al. 2024

J Midwife Womens Health

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IntroductionIntrahepatic cholestasis of pregnancy (ICP) is a problem with an increasing incidence and negative maternal, fetal, and neonatal consequences. This problem is becoming increasingly important. This systematic review and meta‐analysis aimed to determine the incidence of ICP and its adverse maternal, fetal, and neonatal adverse outcomes based on primary research studies.MethodsThis systematic review and meta‐analysis used Preferred Reporting Items for Systematic Reviews and Meta‐Analyses reporting guidelines and was conducted between June and September 2023 using the following keywords: obstetric cholestasis OR intrahepatic cholestasis AND pregnancy OR pregnant OR prenatal OR antenatal OR perinatal OR maternal OR fetal OR neonatal. Quality assessment of the studies was performed using the Critical Appraisal Checklists developed by the JBI Institute. Data were synthesized using meta‐analysis methods.ResultsThe analysis included 10 studies published between 2013 and 2023. The meta‐analysis showed that the incidence of ICP was 1.7% (odds ratio [OR], 0.021; 95% CI, 0.012‐0.027), whereas maternal, fetal, and neonatal adverse outcomes included cesarean birth (OR, 2.938; 95% CI, 1.467‐5.881), preterm birth or preterm prelabor rupture of membranes (OR, 4.241; 95% CI, 1.996‐9.009), hypertensive disorders of pregnancy (OR, 3.715; 95% CI, 1.545‐8.929), maternal infection (OR, 3.301; 95% CI, 2.917‐3.737), neonatal intensive care unit admission (OR, 2.715; 95% CI, 1.458‐5.056), birth weight less than or equal to 2500 g (OR, 2.518; 95% CI, 1.296‐4.892), and small for gestational age (OR, 1.915; 95% CI, 1.424‐2.573).DiscussionThis systematic review and meta‐analysis revealed that ICP has a high incidence and several maternal, fetal, and neonatal adverse outcomes. Therefore, midwives and other health professionals must be aware of these outcomes and provide appropriate care to pregnant individuals with ICP.

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