Obstetric antiphospholipid syndrome

Galarza-Maldonado, Claudio; Kourilovitch, María; Pérez-Fernández, Oscar M.; Gaybor, Mariana; Cordero, Christian; Cabrera, Sonia; Сорока, Н.Ф.

doi:10.1016/j.autrev.2011.10.006

Cited by 64 publications

(33 citation statements)

References 47 publications

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“…Although venous and arterial thromboses have classically been reported to be the most common and serious complications associated with aPL, and the majority of these patients will have thrombotic phenomena [24], complete agreement regarding these concerns is lacking. Some clinicians and researchers are convinced that certain cases will have only obstetric complications with no or few thrombotic, other than placental, episodes over time [2,[10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

Alijotas‐Reig

Ferrer‐Oliveras

Ruffatti

et al. 2015

Autoimmunity Reviews

117

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OAPS shows differential characteristics than classical APS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. OAPS has very good foetal-maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms.

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Section: Discussionmentioning

confidence: 99%

The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

Alijotas‐Reig

Ferrer‐Oliveras

Ruffatti

et al. 2015

Autoimmunity Reviews

117

View full text Add to dashboard Cite

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“…Recently, we published a metaanalysis based on the literature [6], which revealed that patients treated with low-dose aspirin had an overall 2-fold reduction in the risk of a first thrombotic event compared to those not treated with aspirin. However, this finding was limited by the lack of adjustment on additional cardiovascular risk factors and the various proportions of patients with asymptomatic aPL, systemic lupus erythematosus (SLE) and obstetrical antiphospholipid syndrome (obsAPS) [7,8] in each included study.…”

Section: Introductionmentioning

confidence: 90%

Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies

Arnaud

Mathian

Devilliers³

et al. 2015

Autoimmunity Reviews

118

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“…It manifests in 5–15% of women with recurrent miscarriage, and is associated with other obstetric complications such as preterm delivery, intrauterine growth restriction, early pre-eclampsia, HELLP syndrome and subchorionic haematoma/placental abruption 37 38. It should be noted that ‘obstetric’ APS refers to women with only obstetric aPL-related complaints and no history of current thrombotic events at the time of diagnosis 39.…”

Section: Aetiology Of and Risk Factors For Recurrent Miscarriagementioning

confidence: 99%

Recurrent miscarriage: causes, evaluation and management

Garrido¹,

Alijotas‐Reig

2015

Postgraduate Medical Journal

198

124

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Recurrent miscarriage is frustrating for the physician and a heartbreaking experience for the patient. Approximately 5% of couples trying to conceive have two consecutive miscarriages. Despite a thorough study of patients, the aetiology of this common obstetric complication is unknown in 50% of cases. Known causes include abnormal chromosomes, endocrinological disorders and uterine abnormalities. Although antiphospholipid antibodies have been demonstrated in miscarriages, the role played by alloimmune mechanisms remains unclear. New immunological approaches such as natural killer cells, regulatory T cells, tumour necrosis factor α, cell-derived microparticles, leptin, certain glycoproteins and cytokines should be considered. The management of thyroid diseases and immunological disorders is continuously evolving. Several genetic diagnostic procedures such as parental karyotyping and preimplantation genetic screening should probably not be used routinely. Antiphopholipid syndrome and some recurrent miscarriage-related endocrinological disorders can be effectively treated. Finally, new therapeutic approaches and the pleiotropic effects of old ones have led to improved fetal-maternal outcomes.

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Obstetric antiphospholipid syndrome

Cited by 64 publications

References 47 publications

The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies

Recurrent miscarriage: causes, evaluation and management

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