Obstetric and perinatal outcomes of pregnancy in patients with repeated implantation failure

Chin, Tzu Hsuan; Hsu, Ya Chiung; Soong, Yung Kuei; Lee, Chyi Long; Wang, Hsin Shih; Huang, Hsiao‐Ping; Wu, Ho‐Ting; Yu, Hsing Tse; Huang, Shang Yu; Chang, Chia‐Lin

doi:10.1016/j.tjog.2019.05.010

Cited by 7 publications

(8 citation statements)

References 57 publications

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“…One reason for this study was that women with RIF have been shown to have an elevated risk of adverse perinatal outcomes. Earlier studies found that patients with a history of RIF had a significantly increased risk of placental abruption among singleton pregnancies ( 14 ), but our study did not find this difference. To our knowledge, although the sample size of our study was limited, this is the first report to analyze the relationship between RIF and neonatal outcomes and obstetric complications in singleton live births only after FET cycles.…”

Section: Discussioncontrasting

confidence: 99%

History of Recurrent Implantation Failure is Associated With the Incidence of Adverse Perinatal Outcomes in Singleton Live Births Following Frozen-Thawed Embryo Transfer Cycles

Guan

Liu

et al. 2022

Front. Endocrinol.

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ObjectiveTo investigate whether patients with a history of recurrent implantation failure (RIF) are associated with adverse perinatal outcomes in singleton live births following frozen-thawed embryo transfer (FET) cycles.DesignRetrospective cohort study.MethodsThis study analyzed the obstetric and neonatal outcomes of patients with and without a history of RIF who underwent FET cycles in a single reproductive center between January 2017 and October 2020. A total of 1,100 women with singleton live births beyond 28 weeks of gestation were included. The primary outcome measures were perinatal outcomes, especially gestational age, birthweight, preterm birth (PTB), large for gestational age (LGA), small for gestational age (SGA), congenital malformation rates, and premature rupture of the membranes (PROM). Multiple logistic regression was used to establish relationships between RIF and adverse perinatal outcomes after adjusting for relevant baseline demographics and cycle characteristics.Result(s)The RIF group showed a preferred transfer of two embryos and cleavage embryos compared with the control group (P <0.05). Regarding perinatal outcomes in singleton deliveries, women with RIF had increased rates of LBW (adjusted odds ratio [aOR] 2.027; 95% confidence interval [CI], 1.025–4.009), PTB (aOR 1.785; 95% CI, 1.050–3.036), and PROM (aOR 2.259; 95% CI, 1.142–4.467). The incidence of congenital malformations was similar between the two groups (4.1% vs. 2.4%; P = 0.759). Furthermore, multiple intrauterine procedures were associated with a statistically significant increased risk of PROM in RIF patients (aOR 1.537; 95% CI, 1.105–2.137).ConclusionsWomen with a history of RIF were associated with an increased risk of LBW, PTB, and PROM in singleton live births after FET cycles. In addition, multiple intrauterine procedures were independent risk factors for PROM.

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Section: Discussioncontrasting

confidence: 99%

History of Recurrent Implantation Failure is Associated With the Incidence of Adverse Perinatal Outcomes in Singleton Live Births Following Frozen-Thawed Embryo Transfer Cycles

Guan

Liu

et al. 2022

Front. Endocrinol.

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“…Therefore, it seems to be reasonable to study RIF and RPL as RF in a common paper, with focus on research aiming to clarify and treat common etiologies such as chromosomal, endocrine, thrombophilic, and immunological causes 10 . Furthermore, pregnancies in women with a history of various RF have shown more obstetric complications such as placental abruption, preeclampsia (PE), and intrauterine growth restriction (IUGR), and some of them resulted in stillbirth 11–15 . This association indicates that common pathophysiology is involved in both obstetric complications and RFs 2,13,16–18 .…”

Section: Introductionmentioning

confidence: 99%

Inherited thrombophilia and anticoagulant therapy for women with reproductive failure

Han

Lee

2020

American J Rep Immunol

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Reproductive failure (RF) is the inability to conceive or to carry a pregnancy to term, and its prevalence is not negligible. Pregnancy is a prothrombotic condition, which can be abnormally exaggerated in women with thrombophilia. Antiphospholipid syndrome is a cause of RF and effectively managed with heparin and aspirin. However, there are yet insufficient data in patients with RF and inherited thrombophilia. This review focuses on the significance of inherited thrombophilia and RF and the role of anticoagulants in pregnancy outcomes. A few randomized case‐control studies have investigated the effect of anticoagulation in RF with thrombophilia, and the results are yet debatable. Some inherited thrombophilia including mutations of factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase and protein S deficiency are associated with RF and/or late pregnancy complications. There are several implications which influence the diagnosis and treatment. First, there is a lack of studies revealing appropriate thrombophilia markers and its cutoff values for RF specifically. Second, some thrombophilia markers change with sex and age. Lastly, the study designs of previous studies are heterogeneous in selecting the thrombophilia markers and drugs. Further studies to find adequate thrombophilia markers of RF are warranted and eventually elucidate the subgroups beneficial to anticoagulation treatment.

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“…The general PTB rate in Taiwan was also very different from that of European (Table 1). 29,38 About the occurrence of preeclampsia, the Korean report cited in this study 32 showed relatively low incidence compared with previous their own data and other international data. They said that the socioeconomic status of those enrolled in that study was relatively higher than those of previous studies.…”

Section: F I G U R E 3 Current Manufacturing Processes For Ivigs Used In This Studymentioning

confidence: 48%

“…25 Various obstetric complications have been reported to have higher incidence in women with a history of RF. [26][27][28][29] There is some report about potential role of immune modulation therapy including IVIG in the prevention of increased risk of obstetrical complications in women with history of RF. 30 According to the data from the Statistics Korea, PTB rate in 2014 was 6.7%, 31 and the incidence of GDM and preeclampsia were 5.6% and 1.4% each at the report on national research project published the same year.…”

Section: F I G U R E 3 Current Manufacturing Processes For Ivigs Used In This Studymentioning

confidence: 99%

“…b A report on national research project investigated the prevalence of obstetric complications in Korea, 201431 . c A previous study investigated obstetric outcomes in women who had history of RPL and/or unexplained infertility and treated with IVIG during pregnancy29 . d A retrospective cohort study investigated perinatal outcomes in a subsequent pregnancy after RPL in Ireland32 .…”

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confidence: 99%

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Maternal and fetal safety of intravenous immunoglobulin in women with reproductive failure

Han

Lee

Park

et al. 2021

American J Rep Immunol

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Problem: Intravenous immunoglobulin G (IVIG) is an emerging regimen for women with reproductive failures (RF) during-or pre-pregnancy who have aberrant cellular immune reactions. Studies investigating teratogenicity of IVIG have been limited.Herein, we evaluated the fetal teratogenicity of IVIG and IVIG-related obstetric complications. Method of study:Women who used IVIG during pregnancy due to RF with cellular immune aberrances were enrolled from four medical centers in Korea. The pregnancy outcomes were collected.Results: A total of 370 RF women who used IVIG during their pregnancy were enrolled.Most of the patients started the IVIG therapy before 12 weeks of gestation and 229 women continued IVIG treatment beyond 12 weeks of gestation. The mean age of the subjects was 34.8 years and the mean total dosage of IVIG was 125.3 g. A total of 307 women had livebirths and six of them were twins. Of 301 singleton livebirths, obstetric complications were developed as follows: preterm births (12.0%), gestational diabetes (7.0%), preeclampsia (4.0%), placental abruption (1.3%), placenta previa (4.3%), and placenta accrete (1.7%). Total six cases (1.99%) had major fetal anomalies in livebirths. The incidence of birth defects is similar to those of the general population in Korea and the previous report in infertile women. No IVIG -related viral contamination was noted. Conclusion:IVIG use during pregnancy did not increase obstetric complications and fetal teratogenicity. This study can be an evidence of maternal and fetal safety of IVIG administration during pregnancy.

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Obstetric and perinatal outcomes of pregnancy in patients with repeated implantation failure

Cited by 7 publications

References 57 publications

History of Recurrent Implantation Failure is Associated With the Incidence of Adverse Perinatal Outcomes in Singleton Live Births Following Frozen-Thawed Embryo Transfer Cycles

History of Recurrent Implantation Failure is Associated With the Incidence of Adverse Perinatal Outcomes in Singleton Live Births Following Frozen-Thawed Embryo Transfer Cycles

Inherited thrombophilia and anticoagulant therapy for women with reproductive failure

Maternal and fetal safety of intravenous immunoglobulin in women with reproductive failure

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