Obstetric and Neonatal Outcomes of Maternal Vitamin D Supplementation: Results of an Open-Label, Randomized Controlled Trial of Antenatal Vitamin D Supplementation in Pakistani Women

Hossain, Nazli; Kanani, Fatima Husain; Ramzan, Shabana; Kausar, Robina; Ayaz, Shabana; Khanani, Rafiq; Pal, Lubna

doi:10.1210/jc.2013-3491

Cited by 127 publications

(173 citation statements)

References 43 publications

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“…The other two studies (15,22) used vitamin D in the treatment group, vs. placebo. The results from the Hossain et al study (20) study seem to have driven the overall RR toward the null. Some studies suggest that calcium supplementation reduces preeclampsia risk (42,43).…”

Section: Vitamin D Supplementation and Preeclampsiamentioning

confidence: 86%

See 1 more Smart Citation

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Pérez‐López

Pasupuleti

Mezones‐Holguín

et al. 2015

Fertility and Sterility

271

205

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Section: Vitamin D Supplementation and Preeclampsiamentioning

confidence: 86%

“…Thus, the possibility that some outcomes could have U-shaped associations, with risks at both low and high levels, cannot be disregarded (59). However, vitamin D supplementation of up to 4,000 IU per day seemed to be safe during pregnancy (8,20).…”

Section: Limitations Of Current Meta-analysesmentioning

confidence: 99%

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Pérez‐López

Pasupuleti

Mezones‐Holguín

et al. 2015

Fertility and Sterility

271

205

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“…Neonatal Serum calcium, S. PO 4 , S. ALP levels did not differ significantly in relation to maternal vitamin D status. (Table 3 [3,6,[14][15][16][17][18][23][24][25]. This highlights the importance of adequate Vitamin D intake for mothers during pregnancy to protect their new borns from the ill-effects of hypo vitaminosis D.…”

Section: Resultsmentioning

confidence: 99%

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Rajoria¹,

Gupta²,

Rajoria³

et al. 2016

SJAMS

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Abstract:The widespread global prevalence of hypovitaminosis D during pregnancy and its implications for undesirable health outcomes in present and future generations is an area of growing concerns. The study was undertaken with an aim to determine vitamin D status among pregnant women and their new-borns and to find association between maternal vitamin D level during pregnancy and neonatal outcome. This hospital based, observational study was conducted on 250 pregnant patients and their new-borns in departments of Obstetrics & Gynaecology and Paediatrics at SMS Medical College, Jaipur from May 2014 to April 2015. Maternal and cord blood samples were drawn at the time of delivery for 25-hydroxy vitamin D, S. calcium, S. phosphorus and S. ALP levels estimation. 86% of women were vitamin D deficient, 12.4% insufficient and only 1.6% had sufficient vitamin D levels. Their new born also showed similar results. Mean neonatal vitamin D level in vitamin D deficient , insufficient , sufficient mothers were 5.73 ± 2.7 ng/ml, 17.77 ± 9.62 ng/ml and 33.09 ± 5.22 ng/ml respectively. Maternal and cord blood vitamin D levels showed significant positive correlation (r = 0.90, P value < 0.001). Maternal Vitamin D status was not significantly associated with neonatal biochemical parameters (S. calcium, S. phosphorus and S. ALP levels) and anthropometry. The strong correlation between 25(OH) D concentrations in mothers and their new-borns indicate that adequate vitamin D intake for mothers should be emphasized through maternal supplementation which would achieve the double effect of preventing vitamin D deficiency in both mothers and children.

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“…A decreased need of mechanical ventilation is an important finding, as even modern invasive ventilator treatment for preterm neonates is associated with an increased risk of complications including BPD (67,99). One other RCT has reported on a lower risk of preterm birth in mothers with resultant higher 25(OH)D, adjusted for race, but gave no lung disease data (100), whereas another smaller RCT of smaller size with later gestational age at enrollment found no difference in gestational age at delivery (43).…”

Section: Discussionmentioning

confidence: 99%

The impact of vitamin D on fetal and neonatal lung maturation. A systematic review

Lykkedegn

Sørensen

Beck-Nielsen

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

116

104

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-Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) are major complications to preterm birth. Hypovitaminosis D is prevalent in pregnancy. We systematically reviewed the evidence of the impact of vitamin D on lung development, surfactant synthesis, RDS, and BPD searching PubMed, Embase, and Cochrane databases with the terms vitamin D AND (surfactant OR lung maturation OR lung development OR respiratory distress syndrome OR fetal lung OR prematurity OR bronchopulmonary dysplasia). Three human studies, ten animal studies, two laboratory studies, and one combined animal and laboratory study were included. Human evidence was sparse, allowing no conclusions. BPD was not associated with vitamin D receptor polymorphism in a fully adjusted analysis. Animal and laboratory studies showed substantial positive effects of vitamin D on the alveolar type II cell, fibroblast proliferation, surfactant synthesis, and alveolarization. These data support the hypothesis of hypovitaminosis D as a frequent, modifiable risk factor of RDS and BPD, which should be tested in randomized controlled trials on pregnant women, those with threatening preterm delivery, or in the preterm neonates. Future experimental and human studies should aim to identify optimal time windows, vitamin D doses, and cut-off levels for 25-hydroxyvitamin D in interventions against RDS, BPD, and later adverse respiratory outcomes. vitamin D; fetus; lung; surfactant; preterm; neonate THE IMPORTANCE OF VITAMIN D in nonskeletal fetal and childhood health has become increasingly recognized in the last decades (19,65). The impact of vitamin D on early lung development and maturation and lung diseases of early life is an emerging field of research. Hypovitaminosis D during pregnancy is associated with reduced placental development and weight, leading to a presumed risk of preterm birth (24,25), which per se may lead to respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). Moreover, vitamin D is suggested to play a role in the embryogenesis and in cellular growth and differentiation, including lung development and regulation of lung maturation in the fetus (23,29,38,70,71,108), whereby hypovitaminosis D could be hypothesized to aggravate premature neonatal lung diseases.Vitamin D is involved in the development of the innate and adaptive immune system, and, because of its unique capacity to bind to the vitamin D receptor (VDR) and thereby to serve as a transcriptional factor, vitamin D can regulate gene expression and exert widespread immunomodulatory effects including proliferation, differentiation, and complex regulation (19, 56, 58 -61, 64, 65, 68, 69, 105). Evidence suggests that vitamin D may stimulate regulatory T cell development and T cell function to suppress inappropriate Th1 and Th2 responses to environmental exposure (i.e., allergens, infection load), leading to a more balanced immune response inhibiting autoimmune diseases (with Th1 dominance) and allergic diseases (Th2 dominance) (55). Vitamin D could therefore be inv...

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Obstetric and Neonatal Outcomes of Maternal Vitamin D Supplementation: Results of an Open-Label, Randomized Controlled Trial of Antenatal Vitamin D Supplementation in Pakistani Women

Abstract: Maternal vitD supplementation improved maternal and neonatal vitD status.

Cited by 127 publications

References 43 publications

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

The impact of vitamin D on fetal and neonatal lung maturation. A systematic review

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