Obsessive-compulsive symptoms in two patients with strategic basal ganglia lesions

Endres, Dominique; Zedtwitz, Katharina von; Urbach, Horst; Dersch, Rick; Runge, Kimon; Feige, Bernd; Nickel, Kathrin; Schiele, Miriam A.; Prüss, Harald; Domschke, Katharina; Reisert, Marco; Coenen, Volker A.

doi:10.1038/s41380-022-01853-8

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…1 Many studies have shown that OCD is a frontal lobe/basal ganglia disorder that shares links with neurodegenerative disorders such as malfunctioning of cortico-striato-thalamo-cortical circuitry, autism, schizophrenia, Tourette syndrome, and frontal lobe dementia. [2][3][4] In addition, neuropsychological findings in cognitive impairments related to spatial working memory, spatial recognition, and motor initiation and execution have been observed in OCD, and also in some other neurodegenerative diseases such as Alzheimer's disease (AD). [5][6][7][8][9] In our previous study, obsessivecompulsive symptoms had been observed in AD, which suggested that pre-existing obsessive-compulsive symptoms may predispose individuals to developing dementia in later life in the case of true memory deficit.…”

Section: Introductionmentioning

confidence: 99%

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms

Dondu,

Caliskan,

Orenay-Boyacioglu

2024

NDT

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Objective Many researchers have considered obsessive compulsive disorder (OCD) to be a neurodegenerative disease just like Alzheimer’s disease (AD). The most studied gene in neurodegenerative diseases is apolipoprotein E (ApoE) gene, and ApoE ɛ4 allele in particular. Although a small number of studies have explored the relationship between ApoE gene polymorphisms and OCD, the link between age at onset of OCD, its subtypes and ApoE gene polymorphisms has not been revealed so far. For this purpose, in our study, the relationship of ApoE gene polymorphisms with age at onset of OCD and its subtypes has been investigated to reveal their neurodegenerative connections. Patients and Methods ApoE gene polymorphisms of 64 OCD and 28 healthy cases were studied using a LightCycler480 real-time PCR platform. Results A statistically significant difference was found between groups of patients with early- and late-onset OCD in terms of age (p = 0.03), educational level (p = 0.00) and marital status (p = 0.002). ApoE ɛ4ɛ4 genotype, the prevalence of which is below 2% in healthy individuals, was not detected in our control groups; however, it was identified in 5.1% of our OCD cases. Correlation analysis revealed the presence of a potentially significant link between the hoarding obsession and presence of the ɛ4ɛ4 genotype. A significant correlation was detected between the presence of the ɛ3ɛ3 allele, the symmetry obsession and associated ordering compulsion in patients with OCD (p<0.005). Conclusion The ApoE gene polymorphism profile and age of onset in OCD patients may play critical roles in the development process of neurodegenerative characteristics of the disease. The small number of cases and the inability to perform brain imaging in patients to detect the neurodegenerative link in OCD are limitations of our study. In this respect, we suggest conduction of further studies with a greater number of patients who will also undergo brain imaging studies. In addition, OCD patients have other genes associated with neurodegenerative diseases that can be screened.

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Section: Introductionmentioning

confidence: 99%

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms

Dondu,

Caliskan,

Orenay-Boyacioglu

2024

NDT

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Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis

von Zedtwitz,

Tebartz van Elst,

Urbach

et al. 2024

J Neural Transm

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Autoimmune-mediated obsessive–compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.

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Obsessive-compulsive symptoms in two patients with strategic basal ganglia lesions

Cited by 2 publications

References 15 publications

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms

Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis

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