Obsessive-Compulsive Hoarding

Saxena, Sanjaya; Maidment, Karron M.; Vapnik, Tanya; Golden, Gina; Rishwain, Tanya; Rosen, Richard; Tarlow, Gerald; Bystritsky, Alexander

doi:10.4088/jcp.v63n0105

Cited by 164 publications

(9 citation statements)

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“…Intensive CBT focused on four main areas: discarding, preventing incoming clutter, organizing, and introducing alternative behaviors. 58 Even though most of the compulsive hoarders had previously failed trials of SRIs or outpatient CBT, they showed significant improvement, with a mean 35% decrease in symptom severity, and 45% of them were classified as responders to treatment. However, non-hoarding OCD patients had significantly greater improvement, with a mean 46% decrease in symptom severity.…”

Section: Combined Multi-modal Treatmentmentioning

confidence: 99%

“…Initial evaluation should include assessment of the amount of clutter, types of items saved, usability of living and work spaces, potential health and safety hazards, beliefs about possessions, information processing deficits, avoidance behaviors, insight, motivation for treatment, social and occupational functioning, and activities of daily living. 58…”

Section: Treatment Of Compulsive Hoarding Initial Assessmentmentioning

confidence: 99%

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Neurobiology and Treatment of Compulsive Hoarding

Saxena

2008

CNS Spectr.

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Compulsive hoarding is a common and often disabling neuropsychiatric disorder. This article reviews the phenomenology, etiology, neurobiology, and treatment of compulsive hoarding. Compulsive hoarding is part of a discrete clinical syndrome that includes difficulty discarding, urges to save, clutter, excessive acquisition, indecisiveness, perfectionism, procrastination, disorganization, and avoidance. Epidemiological and taxometric studies indicate that compulsive hoarding is a separate but related obsessive-compulsive spectrum disorder that is frequently comorbid with obsessive-compulsive disorder (OCD). Compulsive hoarding is a genetically discrete, strongly heritable phenotype. Neuroimaging and neuropsychological studies indicate that compulsive hoarding is neurobiologically distinct from OCD and implicate dysfunction of the anterior cingulate cortex and other ventral and medial prefrontal cortical areas that mediate decision-making, attention, and emotional regulation. Effective treatments for compulsive hoarding include pharmacotherapy and cognitive-behavioral therapy. More research will be required to determine the etiology and pathophysiology of compulsive hoarding, and to develop better treatments for this disorder.

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Section: Combined Multi-modal Treatmentmentioning

confidence: 99%

Section: Treatment Of Compulsive Hoarding Initial Assessmentmentioning

confidence: 99%

Neurobiology and Treatment of Compulsive Hoarding

Saxena

2008

CNS Spectr.

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“…Also, OCD patients who described hoarding as their primary symptom showed significant improvement after a 6-week daily multimodal therapy including SSRIs, CBT based on Frost and Hartl's model [78], and psychosocial rehabilitation. Although HD patients showed less improvement than non-HD patients, their Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores at the end of treatment were significantly decreased [83].…”

Section: The Split Of Hd From Ocd Ensued In Diversified Treatmentmentioning

confidence: 99%

Pharmacotherapy for Hoarding Disorder: How did the Picture Change since its Excision from OCD?

Piacentino

Pasquini

Cappelletti

et al. 2019

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This brief review deals with the various issues that contributed to the creation of the new Diagnostic and Statistical Manual condition of hoarding disorder (HD) and attempts at reviewing its pharmacotherapy. It appears that after the newly founded diagnosis appeared in the literature as an autonomous entity, distinct from obsessive-compulsive disorder, drug trials are not being conducted and the disorder is left in the hands of psychotherapists, who on their part, report fair results in some core dimensions of HD. The few trials on HD specifically regard the serotonin-noradrenaline reuptake inhibitor venlafaxine, and, possibly due to the suggestion of a common biological background of HD with attention-deficit/hyperactivity disorder, the psychostimulant methylphenidate and the noradrenaline reuptake inhibitor atomoxetine. For all these drugs, positive results have been reported, but the evidence level of these studies is low, due to small samples and non-blind designs. Regretfully, there are currently no future studies aiming at seriously testing drugs in HD.

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“…Many studies (Abramowitz et al, 2008;Black et al, 1998;Hahm et al, 2001;Lambrecq et al, 2009;Luchian et al, 2007;Mataix-Cols et al, 1999, 2003Saxena et al, 2002;Winsberg, Cassic, & Koran, 1999) show that selective serotonin reuptake inhibitors (SSRIs) are ineffective for hoarding. These findings may imply that serotonin is unlikely to be the predominant neurotransmitter involved in hoarding, although drawing inferences about etiology from medication response is fraught with numerous conceptual difficulties (Ross & Pam, 1995).…”

Section: Tablementioning

confidence: 99%

Evaluating an Animal Model of Compulsive Hoarding in Humans

Andrews-McClymont

Lilienfeld

Duke

2013

Review of General Psychology

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Recently, researchers have begun to advocate use of an animal model for understanding compulsive hoarding in humans. Nevertheless, a comprehensive review of the literature for this argument is lacking. We compare data for compulsive hoarding behavior in humans with hoarding in several vertebrates (rat, bird, and primate) to examine the potential validity of an animal model of hoarding. Although the strength of each animal model varies, there is provisional evidence in support of an analogue between hoarding in nonhuman animals (especially rodents) and humans, most notably on neurobiological grounds. Nevertheless, substantially more evidence is needed before this relationship can be confirmed with confidence. We identify gaps in the literature and offer suggestions for further investigation of the validity of animal models of human hoarding.

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Obsessive-Compulsive Hoarding

Cited by 164 publications

References 1 publication

Neurobiology and Treatment of Compulsive Hoarding

Neurobiology and Treatment of Compulsive Hoarding

Pharmacotherapy for Hoarding Disorder: How did the Picture Change since its Excision from OCD?

Evaluating an Animal Model of Compulsive Hoarding in Humans

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