Obsessive-compulsive disorder: Is there a frontal lobe dysfunction?

Khanna, Sumant

doi:10.1016/0006-3223(88)90171-0

Cited by 57 publications

(30 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Khanna concluded that in most cases there was no obvious EEG abnormality in OCD; when it was present it was likely to be a non-specific disturbance in the temporal and frontotemporal regions. [66]…”

Section: Neurobiologymentioning

confidence: 99%

An overview of Indian research in obsessive compulsive disorder

Reddy

Rao

Khanna

2010

Indian J Psychiatry

Self Cite

View full text Add to dashboard Cite

Obsessive-compulsive disorder (OCD) was considered a relatively rare disorder until about two decades ago. Since then, considerable advance has been made in understanding the various aspects of OCD that include epidemiology, clinical features, comorbidity, biology and treatment. In the last one decade, there has also been interest in a group of related disorders called obsessive-compulsive spectrum disorders. There is substantial research from India on various aspects of OCD, particularly from the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore. We attempt to review all the relevant Indian data on OCD.

show abstract

Section: Neurobiologymentioning

confidence: 99%

An overview of Indian research in obsessive compulsive disorder

Reddy

Rao

Khanna

2010

Indian J Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The biological nature of OCD has been investigated in several studies [Baxter et al, 1987;Zohar and Insel, 1987;Khanna, 1988] which indicated involvement of the basal ganglia, the thalamus, and the frontal cortex [Perani et al, 1995;Zohar and Insel, 1988].…”

Section: Introductionmentioning

confidence: 99%

Complex segregation analysis for obsessive compulsive disorder and related disorders

et al. 1999

View full text Add to dashboard Cite

Complex segregation analysis was applied to a sample of 107 Italian families with probands with obsessive compulsive disorder (OCD), using regressive logistic models to test for possible models of genetic transmission. We used two different phenotypic definitions of affection: 1) OCD; and 2) OCD plus Tourette's syndrome/chronic motor tics (CMT). Because of the potential relationship between OCD, Tourette's syndrome (TS), and other tic disorders, we considered these diagnoses to be determined by the same liability in subsequent steps of the analysis. For the 107 OCD families, the best fit was a dominant model of transmission (with a higher penetrance for females). When the phenotype boundaries were widened (OCD + CMT + TS), an unrestricted model of transmission became the best fit. We concluded that additional data are needed to support the hypothesis that Tourette's syndrome and OCD share a common etiology: on the basis of clinical and epidemiological considerations, the OCD phenotype probably presents a higher level of heterogeneity than the TS phenotype, and it could be regulated through different etiologic pathways.

show abstract

“…In a detailed quantitative electroencephalographic (QEEG) study, Khanna found decreased power in the nondominant frontotemporal and posterior temporal regions (15). In an important study using QEEG and brain mapping, Perros and others found significantly increased relative power in the theta-2 band in the left temporal and central regions and significantly reduced variability in frontal and temporal regions (16).…”

mentioning

confidence: 99%

Association of QEEG Findings with Clinical Characteristics of OCD: Evidence of Left Frontotemporal Dysfunction

et al. 2002

View full text Add to dashboard Cite

Objective: Our objectives were 1) to determine hemispheric asymmetry and regional differences on the EEGs of patients with obsessive-compulsive disorder (OCD); and 2) to investigate the effects of sex, treatment response, illness duration, and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores on quantitative electroencephalographic (QEEG) measurements. Method:We recorded EEGs (12-channel) from 22 unmedicated patients with OCD but no depression and from 20 age-and sex-matched control subjects. All patients and control subjects underwent detailed neurological and psychiatric evaluations including the Hamilton Depression Rating Scale (HDRS) and Y-BOCS.Results: QEEG revealed higher frequencies of slow-wave bands and lower frequencies of alpha activity at predominantly left frontotemporal localization in patients with OCD, compared with control subjects. Analysis of variance of QEEG parameters and clinical characteristics showed that sex had a significant effect on delta and alpha frequencies of frontotemporal areas during hyperventilation (HV). Increasing total Y-BOCS score correlated positively with increased frequencies of right parietal delta activity and decreased frequencies of right frontotemporal alpha activity during HV. A significantly increased left frontal slow-wave activity and decreased beta activity during HV in treatment responders led us to consider that frontal lobe functions were better in this group of patients. Illness duration had no important effect on QEEG. Conclusion:Patients with OCD showed important frontotemporal dysfunction, predominantly in the left hemisphere. This was particularly evident in female subjects and in treatment responders. QEEG may be beneficial in understanding the neurobiological basis of OCD. (Can J Psychiatry 2002;47:538-545) See page 544 for author affiliations.Clinical Implications · The finding of left frontotemporal dysfunction observed in visual EEG in patients with obsessivecompulsive disorder (OCD) has been confirmed by quantitative electroencephalographic (QEEG) measurements. · Left frontotemporal dysfunction was most significant in female patients with OCD and in treatment responders. · The severity of left frontotemporal dysfunction correlated positively with the severity of OCD. Limitations · Because specific software was lacking, we performed QEEG analysis by transferring the data obtained from the EEG equipment software to a statistical computer program, and this method may have caused some errors. · A second QEEG analysis was not performed at the end of the treatment period. · A single activation method (hyperventilation) was used in EEG. · The number of male patients was relatively low.

show abstract

Obsessive-compulsive disorder: Is there a frontal lobe dysfunction?

Cited by 57 publications

References 47 publications

An overview of Indian research in obsessive compulsive disorder

An overview of Indian research in obsessive compulsive disorder

Complex segregation analysis for obsessive compulsive disorder and related disorders

Association of QEEG Findings with Clinical Characteristics of OCD: Evidence of Left Frontotemporal Dysfunction

Contact Info

Product

Resources

About