Obsessive-Compulsive Disorder: Diagnosis, Epidemiology, Etiology, and Treatment

Sassano-Higgins, Sean; Pato, Michele T.

doi:10.1176/appi.focus.130211

Cited by 12 publications

(8 citation statements)

References 180 publications

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“…Obsessive-compulsive disorder (OCD) was originally believed to be a rare mental illness. However, recent surveys and research have shown that OCD is one of the most common mental disorders (Sassano-Higgins & Pato, 2015). The study's results…”

Section: Introductionmentioning

confidence: 79%

Sertraline on Obsessive Compulsive Disorders in Indonesia (A Case Study)

Faisal

Algristian²,

AS³

2023

IIMJ

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Background: Obsessive-compulsive disorder (OCD) was originally believed to be a rare mental illness. However, recent surveys and research have shown that OCD is one of the most common mental disorders. Research in India showed that the treatment of OCD using SSRIs (selective serotonin reuptake inhibitors) is preferred over the tricyclic group. This paper will discuss sertraline as the alternative to clomipramine for OCD. Objective: Clomipramine as the treatment of choice for OCD is no longer included in the Indonesian MIMS index. Recent research suggests sertraline is preferred over clomipramine, and this paper discusses the efficacy of sertraline through a case study. Methods: This study is a retrospective descriptive study on the case of 21-year-old male met the ICD-X criteria of OCD for having unwanted thoughts and repetitive behavior for locking the door and orderly compiling the books. The symptoms developed since he graduated from high school (three years before admission) and got worse since the last year. Sertraline was prescribed in the first place. The patient was routinely monitored during each visit for the next three months. Results: The symptoms improved significantly after routinely taking sertraline for two months. The adverse effects were well-tolerated, such as nausea, headaches, and tachycardia. Psychotherapy was needed to modify the patient’s obsession and to anticipate the risk of personality disorder should be noticed because the disorder appeared at a young age. Conclusion: Sertraline as well as psychotherapy are worthy of consideration as first-line OCD therapy in Indonesia.

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Section: Introductionmentioning

confidence: 79%

Sertraline on Obsessive Compulsive Disorders in Indonesia (A Case Study)

Faisal

Algristian²,

AS³

2023

IIMJ

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“…Obsessive-Compulsive Disorder (OCD) is a very debilitating psychological disorder characterized by the presence of unwanted, disturbing thoughts and anxiety or repetitive behaviors causing distress and explicit disorder. [ 1 ] The lifetime prevalence of OCD is approximately 2%,[ 2 ] and its prevalence in Iran is reported to be 21.57%. [ 3 ] Due to OCD's clinical features, the patients' families often change their daily activities in response to symptoms, in an attempt to relieve anxiety and/or reduce the time spent in the rituals.…”

Section: Introductionmentioning

confidence: 99%

Effect of family and patient centered empowerment program on depression, anxiety and stress in patients with obsessive-compulsive disorder and their caregivers' burden

Heidari

Mousavi

Mousavinasab

et al. 2020

Iranian J Nursing Midwifery Res

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Background: Considering the importance of family participation in patients' treatment and the positive effects of simultaneous patient and family education, this study was conducted to determine the effect of a family and patient-oriented empowerment program on depression, anxiety, and stress in patients with Obsessive-Compulsive Disorder (OCD) and their caregivers' burden. Materials and Methods: This quasi-experimental study was conducted on 50 OCD patients along with their primary caregivers. The intervention group participated in eight sessions of training, each lasting from 60 to 90 min (twice a week), and the control group received the usual treatment. The Depression, Anxiety and Stress Scale, Maudsley's Obsessive-Compulsive Inventory, Goldberg's General Health Questionnaire, and Zarit's Burden Inventory were used to collect the data before, immediately after and 1 month after the intervention, and then the gathered data were analyzed with t -test and analysis of variance using the Statistical Package for the Social Sciences software, version 21. Results: The changes in the mean scores of depression (F 2,48 = 21.02, p < 0.001), anxiety (F 2,48 = 29.72, p < 0.001), and stress (F 2,48 = 16.52, p < 0.001) of the patients in the intervention group showed significant decrease over time; however, in the control group, there was no significant decrease in the mean scores of depression (F 2,48 = 1.69, p = 0.19), anxiety (F 2,48 = 0.47, p = 0.62), and stress (F 2,48 = 1.09, p = 0.34) over time. The changes in the caregiver's burden score in both groups indicated a significant decrease over time in the intervention group (F 2,48 = 24.70, p < 0.001) and the control group (F 2,48 = 33. 30, p < 0.001). Conclusions: The findings of this study revealed that concurrently training the patients and caregivers could reduce the negative emotions of the patients and their caregivers' burden.

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“…Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric condition that affects 3% of the population worldwide1–3 and ~1.8% in Iran 4. Overall, the prevalence of OCD is slightly more in women than men with an earlier onset in the male patients 5…”

Section: Introductionmentioning

confidence: 99%

<p>Fluvoxamine treatment response prediction in obsessive-compulsive disorder: association rule mining approach</p>

Hasanpour

Meibodi

Navi

et al. 2019

NDT

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Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder characterized by intrusive thoughts or repetitive behaviors. Clinicians use serotonin reuptake inhibitors (SRIs) for OCD treatment, but 40%–60% of the patients do not respond to them adequately. Here, we described an association rule mining approach for treatment response prediction using an Iranian OCD data set. Patients and methods Three hundred and thirty OCD patients fulfilling DSM-5 criteria were initially included, but 151 subjects completed their pharmacotherapy which was defined as 12-week treatment with fluvoxamine (150–300 mg). Treatment response was considered as >35% reduction in the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score. Apriori algorithm was applied to the OCD data set for extraction of the association rules predicting response to fluvoxamine pharmacotherapy in OCD patients. We considered the association of each attribute with treatment response using interestingness measures and found important attributes that associated with treatment response. Results Results showed that low obsession and compulsion severities, family history of mental illness, illness duration less than 5 years, being married, and female were the most associated variables with responsiveness to fluvoxamine pharmacotherapy. Meanwhile, if an OCD patient reported a family history of mental illness and his/her illness duration was less than 5 years, he/she responded to 12-week fluvoxamine pharmacotherapy with the probability of 91%. We also found useful and applicable rules for resistant and refractory patients. Conclusion This is the first study where association rule mining approach was used to extract predicting rules for treatment response in OCD. Application of this method in personalized medicine may help clinicians in taking the right therapeutic decision.

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Obsessive-Compulsive Disorder: Diagnosis, Epidemiology, Etiology, and Treatment

Cited by 12 publications

References 180 publications

Sertraline on Obsessive Compulsive Disorders in Indonesia (A Case Study)

Sertraline on Obsessive Compulsive Disorders in Indonesia (A Case Study)

Effect of family and patient centered empowerment program on depression, anxiety and stress in patients with obsessive-compulsive disorder and their caregivers' burden

<p>Fluvoxamine treatment response prediction in obsessive-compulsive disorder: association rule mining approach</p>

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