Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study

Asbahr, Fernando Ramos; Negrão, André Brooking; Gentil, Valentim; Zanetta, Dirce Maria Trevisan; Paz, José Albino da; Marques-Dias, Maria Joaquina; Kiss, Maria Augusta P. D.

doi:10.1176/ajp.155.8.1122

Cited by 99 publications

(49 citation statements)

References 7 publications

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“…138,139 Streptococcal infection, RF and the impact on future studies Based on reports of a higher prevalence of OCD in patients with Sydenham's chorea (SC, the neurological manifestation of RF), a number of studies were undertaken and the results suggest a possible relationship between streptococcus infection and OCD. 140 Additional studies reported a higher prevalence of OCD and TS in RF, even without SC, both in active 141,142 and nonactive 143 phases. Furthermore, familial aggregation of OCD/TS has been described in relatives of RF cases (Hounie et al, personal communication).…”

Section: Environmental Factorsmentioning

confidence: 94%

Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can vary both within and across patients over time. This variability in the phenotypic expression has led to the hypothesis that OCD is a heterogeneous disorder and that this heterogeneity obscures the findings of clinical, natural history and treatment response studies and complicates the search for vulnerability genes. A complete understanding of what comprises OCD and the underlying etiological mechanisms will require a dramatic change in how the disorder is conceptualized. In this review, several different approaches that may represent the first steps in this reconceptualization are discussed. These approaches include (1) narrowing the phenotype to identify categorically defined more homogeneous and mutually exclusive subtypes of OCD, (2) considering OC symptom dimensions as quantitative components of the more complex OCD phenotype and (3) broadening the phenotype to include other etiologically related conditions. A combined dimensional approach within distinctive subgroups is proposed as probably the most effective in helping to identify the heritable components of OCD. By identifying heritable components of OCD, it should be possible to find genes for these separate components. The review continues with the illustration of the possible role of some epigenetic risk and protective factors in the OCD presentation and the relevance of examining associated traits and/or endophenotypes to enhance our ability to understand the genetic basis of OCD. To conclude, we discuss the variability in treatment outcome and the significance of the development of specific pharmacological and/or behavioral based therapies tailored to each of these phenotypes. Molecular Psychiatry (2005) 10, 258-275.

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Section: Environmental Factorsmentioning

confidence: 94%

Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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“…7 In Brazil, in a study of 30 patients with chorea, OCD and/or tics were observed in 70% of cases. 10 Studies comparing children with OCD and/or tics and a healthy control group revealed that the former were more closely associated with streptococcal infections, suggesting that the symptoms might result from infectious autoimmune phenomena.…”

Section: Streptococcimentioning

confidence: 99%

PANDAS: uma nova doença?

Oliveira¹

2007

J. Pediatr. (Rio J.)

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The use of antimicrobial and immunologic therapy has been investigated and considered feasible in some cases. Conclusions:Further research is still necessary in order to answer the question posed in the title of this article. In the meantime, the identification of tic disorders and obsessive-compulsive disorders in children should include the possibility of PANDAS, seeking to provide evidence of previous streptococcal infection.

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“…Relatos de casos vêm sugerindo, desde o século XIX, uma relação ente coréia de Sydenham, a manifestação da febre reumática no SNC, obsessões e tiques. Mais recentemente, estudos sistematizados verificaram prevalências aumentadas de SOC e TOC em crianças com coréia de Sydenham [54][55][56] .…”

Section: Imunologiaunclassified

The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome

Mercadante¹,

Rosario²,

Sato³

2004

J Pediatr (Rio J)

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Objective: To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome. Sources of data:A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed.Summary of the findings: Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders. ResumoObjetivo: Revisar as teorias e evidências das bases neurobiológi-cas do transtorno obsessivo-compulsivo e da síndrome de Tourette. Fontes dos dados:Revisão dos estudos que investigam a neuroanatomia, neuroimagem, genética e imunologia desses transtornos. Síntese dos dados:Os comportamentos ritualísticos e pensamentos repetitivos têm sido cada vez mais estudados em nosso meio. As definições dessas entidades formam um continuum espectral de sintomas com prevalência significativa na população.Conclusões: Os avanços das neurociências possibilitaram a exploração dos aspectos genéticos do sistema nervoso central e seu funcionamento, fornecendo novas perspectivas para o tratamento de pacientes com transtorno obsessivo-compulsivo e síndrome de Tourette. As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette

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Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study

Abstract: The association between Sydenham's chorea and OCD supports suggestions that similar mechanisms involving the basal ganglia underlie both disorders. Obsessive-compulsive symptoms occurred at the beginning of rheumatic fever, so early psychopathological assessments are essential.

Cited by 99 publications

References 7 publications

Obsessive-compulsive disorder phenotypes: implications for genetic studies

Obsessive-compulsive disorder phenotypes: implications for genetic studies

PANDAS: uma nova doença?

The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome

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