Obsessions and compulsions associated with cocaine abuse

Sl, Satel; Cj, McDougle

doi:10.1176/ajp.148.7.947a

Cited by 21 publications

(1 citation statement)

References 3 publications

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“…In particular, cocaine use can cause panic attacks, phobic reactions, compulsions and obsessions, which may persist after cessation of use [31][32][33]. The comorbidity between cocaine use and social phobia [34] and post -traumatic stress disorder [35,36] tends to occur among people with severe cocaine use / abuse and family or personal history of disorders [37]. Cocaine users seeking treatment also report significant levels of anxiety and panic, as a side effect of cocaine use [31,38].…”

Section: Introductionmentioning

confidence: 99%

Possible correlations between cocaine use, generalized anxiety and panic disorders in adolescents and young adults: a review of the literature

2021

DAH

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Section: Introductionmentioning

confidence: 99%

Possible correlations between cocaine use, generalized anxiety and panic disorders in adolescents and young adults: a review of the literature

2021

DAH

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Serotonin and Beyond: A Neurotransmitter Perspective of OCD

Abudy

Juven‐Wetzler

Sonnino

et al. 2012

Obsessive‐Compulsive Disorder

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Amisulpiride augmentation in treatment resistant obsessive–compulsive disorder: an open trial

Metin

Yazıcı

Tot

et al. 2003

Human Psychopharmacology

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Despite the effectiveness of clomipramine and selective serotonin reuptake inhibitors (SSRIs) in the treatment of obsessive-compulsive disorder (OCD), 40% to 60% of patients who receive an adequate treatment with these agents have significant persisting symptoms. Newer atypical antipsychotic drugs showed efficacy as augmenting agents in patients with OCD resistant to serotonin reuptake inhibitors (SRIs). The objective of this study was to evaluate the efficacy and safety of amisulpiride augmentation in treatment resistant OCD. A total of 20 patients diagnosed with OCD according to DSM-IV criteria and having a history of resistance to treatment with SRIs were included in the study. Amisulpiride 200 mg/day was added to ongoing SRI treatment and titrated up to 600 mg/day in flexible doses. The mean amisulpiride dose was 325 +/- 106 mg/day. The patients were assessed with the Yale-Brown obsessive-compulsive scale (Y-BOCS) at baseline and at week 12 of amisulpiride treatment. Side effects were monitored by the UKU side effect rating scale. The reduction in Y-BOCS scores between the baseline (26.7 +/- 6.3) and the end of the treatment (12.5 +/- 2.8) was statistically significant (p=0.0001). The most commonly observed side effects included weight gain (14 patients, 70%), mild sedation (13 patients, 65%) and asthenia (7 patients, 35%). This study has several limitations and, hence, the results are preliminary and require confirmation in a randomized controlled trial. In conclusion, this study suggests that amisulpiride may be a promising option as an augmentation strategy in treatment resistant OCD.

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Obsessions and compulsions associated with cocaine abuse

Cited by 21 publications

References 3 publications

Possible correlations between cocaine use, generalized anxiety and panic disorders in adolescents and young adults: a review of the literature

Possible correlations between cocaine use, generalized anxiety and panic disorders in adolescents and young adults: a review of the literature

Serotonin and Beyond: A Neurotransmitter Perspective of OCD

Amisulpiride augmentation in treatment resistant obsessive–compulsive disorder: an open trial

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