Observing Clearance Pathway in Alzheimer Patients Using T2 Component Analysis

Abstract

A method to visualize possible waste clearance pathway in the brain was proposed earlier. The method is based on an assumption that there exist water containing macromolecules along the clearance pathway, and this water can be visualized using T2 component analysis. Preliminary results of this method applied for Alzheimer patients, as well as healthy volunteers, are presented. Distinct differences between the patients and healthy volunteers were observed. It is expected that this method can be a powerful tool for understanding the patho-physiology of the Alzheimer disease.