Observing Anthropometric and Acanthosis Nigrican Changes Among Children Over Time

Law, Jennifer; Northrup, Karen; Wittberg, Richard; Lilly, Christa; Cottrell, Lesley

doi:10.1177/1059840513485986

Cited by 2 publications

(3 citation statements)

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“…Furthermore, the 2-year changes in AN status were more dynamic in the current study, as 8.4% of children changed their status of having or not having AN compared to 2.4% in the study by Law, which represented a cohort of White children in West Virginia. Our study is consistent with previous longitudinal pediatric studies that have consistently reported that the presence of AN is associated with obesity [ 52 , 53 ]. Our current study provides evidence that an increase in the BMI z-score, after adjusting for baseline z-scores, was associated with chronically presenting with AN, while a decrease in the BMI z-score was associated with a remission of AN.…”

Section: Discussionsupporting

confidence: 93%

“…The 5% prevalence of AN in this sample is greater than in past studies. Law et al [ 52 ] conducted a 2-year follow-up study with an initial 1% AN prevalence in 4059 children in kindergarten to second grade. Furthermore, the 2-year changes in AN status were more dynamic in the current study, as 8.4% of children changed their status of having or not having AN compared to 2.4% in the study by Law, which represented a cohort of White children in West Virginia.…”

Section: Discussionmentioning

confidence: 99%

“…Multinominal odds ratios (MORs) were calculated using multinominal regression [ 51 ] to determine factors associated with changes in AN status over the two years as classified by Law et al [ 52 ]. Four groups of children were identified: (1) AN not present at both periods (Never), (2) AN present at baseline and follow-up (Chronic), (3) AN present only at follow-up (Developed), and (4) AN present only at baseline and not at follow-up (Remission).…”

Section: Methodsmentioning

confidence: 99%

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Diet and Acanthosis Nigricans over a Two-Year Period in Children of the Pacific Region

et al. 2023

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Background: The impact that dietary carbohydrates have on children developing type 2 diabetes remains controversial. Furthermore, there are limited pediatric longitudinal studies on changes in body mass index (BMI) and diet related to the development of acanthosis nigricans (AN), a risk factor associated with type 2 diabetes. Methods: Two 24 h dietary records were collected for 558 children, 2–8 years of age, at baseline and at a 2-year follow-up. Data on age, sex, BMI, and the presence of AN were also collected at each time point from the Children’s Healthy Living Program. Logistic regression was used to determine factors associated with the presence of AN at follow-up. Multinominal regression was used to determine factors associated with changes in AN status. Linear regression was used to measure the associations between changes in dietary intake and in the Burke Score for AN. Results: AN was present in 28 children at baseline and 34 children at follow-up. Adjusting for the presence of AN at baseline, age, sex, study group, baseline BMI, change in BMI z-score, time between assessments, and baseline intake, an increase from baseline for each teaspoon of sugar and serving of carbohydrate-rich food increased the risk for having AN at follow-up by 9% and 8%, respectively (p ≤ 0.05). An increased intake of added sugar (teaspoons) increased the risk of developing AN by 13% (p ≤ 0.01) and an increase in servings of foods rich in starch increased the risk of developing AN by 12% (p ≤ 0.01) compared to children who never had AN. Increasing the intake of fruit was also associated with decreased Burke Scores using multiple regression. However, the intake of energy and macronutrients were not associated with AN. Conclusions: Added sugar and foods rich in starch were independently associated with the occurrence of AN, suggesting the type of carbohydrates consumed is a factor in AN occurrence.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Diet and Acanthosis Nigricans over a Two-Year Period in Children of the Pacific Region

et al. 2023

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Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges

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2016

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Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associated with insulin resistance and has a unique role in secondary prevention. The purpose of this narrative review is to provide a comprehensive overview of AN in obese adolescents, covering its history, current knowledge on the condition, its clinical significance, management challenges, and the direction of future research.

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Observing Anthropometric and Acanthosis Nigrican Changes Among Children Over Time

Cited by 2 publications

References 23 publications

Diet and Acanthosis Nigricans over a Two-Year Period in Children of the Pacific Region

Diet and Acanthosis Nigricans over a Two-Year Period in Children of the Pacific Region

Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges

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