Observer variation and discriminatory value of biopsy features in inflammatory bowel disease.

Abstract

If skilled histopathologists disagree over the same biopsy specimen, at least one must have an incorrect interpretation.

Current application of proteomics in biomarker discovery for inflammatory bowel disease

“…Diffe rentiating between subtypes of IBD sometimes has a degree of uncertainty due to overlapping clinical and pathological features [1] . Despite clinical evaluation, radiological, endoscopic and histopathological testing by expert physicians, up to 20% of IBD cases are classified as "indeterminate colitis" or "IBD undifferentiated" [2,3] . However, accurate classification of IBD is essential as response to medication, surgical indications and prognosis can vary between UC and CD [4] .…”

The Importance of Clinicopathological Features for Differentiation Between Crohn’s Disease and Ulcerative Colitis.

“…Tsang, (1999) reported that there are major and minor criteria for the diagnosis of UC, the major ones were: patchy mucosal inflammatory infiltrate, basal plasmacytosis, neutrophils overrunning mucosa, crypt abscesses, cryptitis, crypt distortion and villiform surface, while the minor criteria were: decreased goblet cells, and Paneth cell metaplasia.(23). Theodossi, et al (1994), suggested that a decrease in mucous content, an irregular or a villous surface, crypt distortion, diffuse crypt abscesses, and cryptitis are predictive of ulcerative colitis rather than of Crohn's disease. (24).…”

“…Theodossi, et al (1994), suggested that a decrease in mucous content, an irregular or a villous surface, crypt distortion, diffuse crypt abscesses, and cryptitis are predictive of ulcerative colitis rather than of Crohn's disease. (24).…”

Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis

“…Severity in ulcerative colitis is generally assessed using symptoms, laboratory data [47] , colonoscopic findings [48][49][50][51][52][53][54][55] and histologic degree of inflammation in the biopsy specimens [15,[56][57][58][59] . Histopathologic assessment is considered the standard for evaluation of disease activity in patients with ulcerative colitis [60] .…”