Observer-based efficiency enhancement in cell-cycle specific therapies

Abstract

Abstract-Cell-cycle specific drugs affect cells when they are in specific phases of their periodic cycle. However, injecting drug's strategy can only by global. This rises the problem of optimizing a global constrained decision variable (drug delivery profile with limited volume) when its effect depends on many local unknown characteristics (the individual cells phases). In this paper, an observer-based framework is proposed that enables a rational decision making in this particular circumstance. Simulation on a simple case are proposed to show the relevance of the proposed framework.