Observations Recueillies au Cours D’un Essai de Traitement de la Méningite Tuberculeuse par la Streptomycine

Dubois, Reuben S.; Linz, R; Leschanowski, H.; Schlesser, R.; Wattiez, R

doi:10.1080/17843286.1948.11716451

Cited by 8 publications

(1 citation statement)

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“…' Later publications (Alperin and Toomey, 1948;American Trudeau Society, 1947 andApplebaum and Halkin, 1947;Bunn, 1948;Cathie, 1949;Choremis, 1948;Debr etal., 1948;Decourt, 1948;Dolivo and Rossi, 1948;Dowling, 1949;Dubois, 1948;'Lancet,' 1948a and1948b;McDermott, 1947;Mann, 1948;Medical Research Council, 1948;Mordasini, 1948;Nau, and Wenzler, 1948;and Rubie and Mohun, 1949) produce an over-all i on that when tuberculous meningitis is treated with sutptomycin most paints die, and that of the minority who survive a considerable number are deaf or paralysed, and others are mentally abnormaL Smith et aL (1948), and linoln and Kirmse (1949) on the contrary, point out that recovered cases have not been left badly crippled either physically or mentaly.…”

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A Study of Ten Children after Treatment with Streptomycin for Tuberculous Meningitis

Lorber¹

1949

Archives of Disease in Childhood

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Following the discvery of streptomycn by Waksman (1944) and his collagues, great hopes were entertained that its use in cases of tuberculosis, and especiy of tuberculous meningts, would be followed by results equally dramatic and good as those with penicillin in pyogenic infection in general and the pyogenic meningitides in paticular. These hopes were engendered by the excellent experimental results in guinea-pigs achieved by Feldman and Hinshaw (1944), but the first few reports of cases of tuberculous meningis treated by streptomycin were so discouraging that opinion swung the other way.

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