Observations on the use of prostaglandin F2α as an abortifacient and effect of gonadotrophin-releasing hormone on ovarian activity after induced abortion during the breeding season in goats

Memon, M.A.; Archbald, L.F.; Olcott, Bruce M.; Memon, Haris; Öz, Hüseyin; Chandler, John E.; Ingraham, R.H.

doi:10.1016/0093-691x(86)90122-6

Cited by 4 publications

(1 citation statement)

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“…Plasmatic concentrations of progesterone showed a dramatic fall in all induced goats at 24 h postinjection. Similar observations have been reported in other studies, where the concentration of plasma progesterone significantly decreased after a single (Bretzlaff and Ott 1983;Alan and Tasal 2002) or double IM injection (Memon et al 1986) of natural PGF 2a with mean values ranging between 0.7 and 2.4 ng ⁄ ml at 24 h post-injection. In the control group, the plasma levels of progesterone started to decrease at day 147 of pregnancy, similarly to that observed in pregnant goats of different breeds (Humblot et al 1990;Sousa et al 1999); in addition, the fall was more gentle than detected in females induced to parturition.…”

Section: Discussionsupporting

confidence: 91%

Use of Luprostiol and Cloprostenol for Induction of Parturition in Pregnant Goats

Batista

Niño

Alamo

et al. 2009

Reprod Domestic Animals

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Pregnant goats were induced to parturition on day 145 of pregnancy, with three different protocols: group Cl (n = 19) was injected intramuscularly (IM) with 75 microg of the prostaglandin analogue R-Cloprostenol; group L (n = 20) was treated IM with 7.5 mg of the prostaglandin analogue Luprostiol; group L(50) (n = 18) was injected IM with 3.75 mg of Luprostiol (IM); in addition, Group S (Control, n = 15) was injected IM with 1 ml of saline solution. Thereafter, goats were continuously observed to record the following parameters: parturition, dystocia incidence, placental delivery and kid and maternal survival. Moreover, blood sampling was performed around kidding and plasma progesterone concentrations were analyzed. The interval from injection to parturition (mean +/- SEM) was not significantly different among the experimental groups: 35.1 +/- 1.5 h, 33.3 +/- 0.9 h and 34.1 +/- 1.8 h (groups Cl, L and L(50), respectively). In the control group, time to parturition was 99.4 +/- 12.1 h (range: 34-166 h). All the goats expelled the foetal membranes within the first 2 h after the induction. The incidence of dystocia due to foetal posture was not significantly different between induced and control goats (21.1%, 20.0%, 22.0% and 20%, for groups Cl, L, L(50) and S, respectively). The percentage of live kids was practically similar between induced goats (93.9%, 94.9% and 92.1%, for groups Cl, L and L(50), respectively); in addition, there was a case of maternal mortality in control group (6.7%; 1/15), whereas there was no mortality in induced goats (0%; 0/57). Plasma concentrations of progesterone showed an intense drop (<2 ng/ml) at 24 h after induction. This study confirms the effectiveness of the luprostiol to induce the parturition in goats, within a narrow range (30-40 h) in most of the induced females (80.0%, 7.5 mg; 77.8%, 3.75 mg).

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