Observations on the presence of intestinal epithelium in the gastric mucosa

Magnus, Hugo

doi:10.1002/path.1700440214

Cited by 90 publications

(25 citation statements)

References 9 publications

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“…Immunoperoxidase method Normal colonic mucosa fragments measuring 10x 1 cm were pinned on cork, fixed for 2 h in a box containing 95% ethanol, coiled up into "swissrolls" (Magnus, 1937) and then, like the tumour samples, incubated overnight in the same fixative and embedded in paraffin. Serial sections (2 jum)…”

Section: Immunochemistrymentioning

confidence: 99%

Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas

Bara¹,

Nardelli²,

Gadenne³

et al. 1984

Br J Cancer

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Section: Immunochemistrymentioning

confidence: 99%

Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas

Bara¹,

Nardelli²,

Gadenne³

et al. 1984

Br J Cancer

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“…One is the intestinal cell, which is accompanied by goblet and Paneth cells, and which occurs in islands which resemble normal intestinal mucosa, although villi are not well developed. Magnus (1937) showed that such intestinal metaplasia is commoner in gastric ulcer than in duodenal ulcer, and it is commoner still in Addisonian anaemia. It might therefore be supposed that it is liable to appear when gastric acidity is low, although Ball and James (1961) were unable to show any association between intestinal metaplasia and gastric acidity among patients with gastric ulcer.…”

Section: Resultsmentioning

confidence: 99%

Gastric Epithelium in the Duodenum

1965

BMJ

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EDITORIAL SYNOPSIS It has been found that a 'gastric' type of epithelium tends to develop in the first part of the duodenum in patients with duodenal ulceration and is found in the second part of the duodenum in a patient with the Zollinger-Ellison syndrome. It is likely that 'gastric' epithelium appears when the duodenal acidity is high and it is resistant to ulceration.The stomach is normally lined by one kind of epithelium and the duodenum by another. Islands of intestinal epithelium have long been known to occur in the stomach, particularly when gastric acidity is low: this paper describes islands of gastric epithelium in the duodenum; they are especially common when gastric, and hence duodenal, acidity is high. These anomalies mirror each other, and the conditions which bring them about throw light, it will be suggested, upon the pathogenesis of peptic ulceration and the determination of its site.Taylor (1927), reviewing heterotopia in the alimentary tract, described two instances of gastric epithelium in the duodenum. They were found among 150 necropsies, and were recognizable as slightly raised patches. Histological examination showed these to be covered by well-preserved gastric epithelium and to contain gastric glands with both chief and parietal cells; Brunner's glands were absent from the patches. In both cases the patches were found in the first part of the duodenum near the pylorus, and in one there was a duodenal ulcer. The presence of gastric glands places these patches in a different category from those described in this paper, where only the epithelium was abnormal. Patzelt (1936) reviewed the histology of the pyloro-duodenal region in animals and man and quoted descriptions which showed that the line of epithelial demarcation was not always sharp, there being islands of intestinal epithelium on the gastric side of the pylorus and, much more rarely, of gastric epithelium on the intestinal side. His article contains an illustration of one such 'Magenepithelinsel' found in the duodenum of a woman; the island appears to cover an inflammatory polyp containing a lymph follicle; no gastric glands were present.

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“…The gradual appearance of the parietal cells, at first in the deep portions of the pyloric glands of the foetus, subsequently in the Brunner's type of glands of the pyloric mucosa and finally in the Brunner's type of glands of the duodenal mucosa and even occasionally within the sub mucosal Brunner's glands would imply th at the parietal cells are dif ferentiated in a sequential m anner within the pyloric glands first and the Brunner's glands last. Magnus [ 1937 ] has suggested th a t the transition from the gastric to the intestinal type of mucosa is abrupt and th a t the appearance of intestinal epithelium in the adult stom ach is abnorm al due to faulty regeneration in a mucosa repeatedly damaged by chronic irritation. But the constant appearance of intestinal epithelium at the pyloric end of the stom ach near the gastroduodenal junction in some late foetal and newborn infant stom achs as well as in healthy adults and children suggests th a t its presence in this part of the stom ach is a normal feature as a result of gradual transition occurring from the gastric to the intestinal type of mucosa.…”

Section: Discussionmentioning

confidence: 99%